Navigation Links
Researchers find possible target to treat deadly bloodstream infections
Date:2/28/2008

Researchers at the University of Illinois at Chicago have discovered a possible target to treat bloodstream bacterial infections.

Most bacterial pathogens can invade the bloodstream, which can lead to severe sepsis, a syndrome that kills about 215,000 of the 750,000 people affected in the United States each year, according to a study published in the journal Critical Care Medicine.

"The growth of bacterial pathogens in blood represents one of the most dangerous stages of infection," said Alexander Mankin, professor and associate director of UIC's Center for Pharmaceutical Biotechnology. "Before we can discover an antibiotic to treat bloodstream infections, we first had to discover which enzymes are essential for bacteria to live in the bloodstream.

"Our major goal was to identify genes that are critical for the survival and growth of bacteria in blood."

The study appears in the February issue of the journal PLoS Pathogens.

A graduate student in Mankin's laboratory, Shalaka Samant, infected human blood in a test tube with E. coli bacteria, a major cause of bloodstream infections in hospitalized patients.

Using a novel technique developed in Mankin's laboratory, Samant discovered that 19 E. coli mutants out of more than 4,000 she tested could not grow in blood. The majority of the mutants carried a deletion of a gene involved in making nucleotides, the building blocks of DNA and RNA.

The result suggested that the biosynthesis nucleotides is crucial for the growth of the bacteria in human blood, Samant said.

Samant expanded her research to another bloodstream pathogen -- Bacillus anthracis, the causative agent of anthrax.

"There are few treatment options available for the late stages of anthrax infections," Samant said. "We found that, similar to E. coli, anthracis bacilli that could not biosynthesize nucleotides also were unable to grow in blood."

To add to Samant's study, a team of researchers led by Dr. James Cook, chief of infectious diseases, immunology and internal medicine at the University of Illinois Medical Center at Chicago, showed Bacillus anthracis mutants that were unable to synthesize nucleotides were not able to infect mice. After they were infected with anthrax, the mice remained healthy, with no bacteria detected in their blood.

Mankin said the enzymes of nucleotide biosynthesis could make excellent antibiotic targets. The UIC Center for Pharmaceutical Biotechnology is now working to identify drugs that inhibit these enzymes.


'/>"/>

Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
Source:Eurekalert

Related medicine news :

1. Rutgers researchers unlock mysteries of vitamin A metabolism during embryonic development
2. U of Minn researchers discover genetic cancer link between humans and dogs
3. New genetic association with schizophrenia found by researchers
4. Thomson Scientific To Honor Australias Top Researchers With Dedicated Australian Research Day
5. This is your brain on jazz: researchers use MRI to study spontaneity, creativity
6. First look: Princeton researchers peek into deepest recesses of human brain
7. U of Minn researchers find primary alcohol prevention programs are needed for tweens
8. Researchers collaborate to find new vaccine technology decreases E. coli in beef cattle
9. Researchers identify and shut down protein that fuels ovarian cancer
10. Implementers, Advocates, Researchers Call on Congress to Honor Lantos Commitment to Public Health and Human Rights by Placing Evidence over Ideology
11. Penn researchers engineer first system of human nerve-cell tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, ... Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments in ... the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... addition of the "Structural Electronics 2015-2025: Applications, ... In-Mold Electronics, Smart ... Integrated Photovoltaics Structural electronics involves ... as load-bearing, protective structures, replacing dumb structures such ...
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: ... and sells medical devices and wearable sleep respiratory products ... cooperation agreement with Hongyuan Supply Chain Management Co., Ltd. ... 20, 2016, to develop Dehaier,s new Internet medical technology ... will leverage Hongyuan Supply Chain,s sales platform to reach ...
Breaking Medicine Technology: