BOSTONScientists at Dana-Farber Cancer Institute and the Broad Institute have found strikingly high levels of a bacterium in colorectal cancers, a sign that it might contribute to the disease and potentially be a key to diagnosing, preventing, and treating it.
In a study published online in the journal Genome Research, investigators report the discovery of an abnormally large number of Fusobacterium cells in nine colorectal tumor samples. While the spike does not necessarily mean the bacterium helps cause colorectal cancer, it offers an enticing lead for further research, the study authors say. The journal is also publishing a paper by researchers from the BC Cancer Agency and Simon Fraser University in Canada that reports similar findings from research conducted independently of the Dana-Farber/Broad Institute collaboration.
A confirmed connection between Fusobacterium and the onset of colorectal cancer would mark the first time any microorganism has been found to play a role in this type of cancer, which is the second leading cause of cancer deaths in the United States. The American Cancer Society estimates that colon cancer will cause more than 49,000 deaths in the U.S. this year, and more than 141,000 people will be diagnosed with the disease.
The discovery was made by sequencing the DNA within nine samples of normal colon tissue and nine of colorectal cancer tissue, and validated by sequencing 95 paired DNA samples from normal colon tissue and colon cancer tissue. Analysis of the data turned up unusually large amounts of Fusobacterium's signature DNA in the tumor tissue.
"Tumors and their surroundings contain complex mixtures of cancer cells, normal cells, and a variety of microorganisms such as bacteria and viruses," says the study's senior author, Matthew Meyerson, MD, PhD, of Dana-Farber and the Broad Institute. "Over the past decade, there has been an increasing focus on the relationship between cancer cells and thei
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Dana-Farber Cancer Institute