Navigation Links
Researchers find possible genetic keys to surviving epithelial ovarian cancer

TAMPA, Fla. (March 6, 2012) Researchers at Moffitt Cancer Center and colleagues from 11 other institutions in the United States and the United Kingdom have used two genome-wide association studies (GWAS) one from the U.S. and one from the U.K. to detect a novel set of genes found to be associated with epithelial ovarian cancer patient survival. The discovery could open the door to new therapies for treating epithelial ovarian cancer (EOC), the most lethal kind of gynecologic malignancy.

The study appeared in a recent issue of Cancer Epidemiology, Biomarkers & Prevention published by the American Association for Cancer Research.

The research team applied gene set analysis (GSA) for the first time to epithelial ovarian cancer gene databases. The gene set analysis mapped 857genes related to EOC that pass signals "downstream" to components in the cell which, in turn, are activated and trigger a change in the state of the cell.

One of the most significant gene sets they analyzed was comprised of a set of eight genes involved in macrolide (a class of drugs) "binding" which interact with immune suppressant FK506 and involve intracellular signaling.

Other studies have indicated that the binding protein (FKBP65) was "highly expressed in ovarian epithelium." FKBP65 has also been found to be inversely associated with the expression of tumor suppressor gene P53.

Researchers expect that the results of their GSA can be used to focus on the role and function of these specific gene sets and may ultimately help uncover additional genetic causes of complex traits.

"Epithelial ovarian cancer is the fifth leading cause of cancer mortality among women in the U.S.," said study co-author Thomas A. Sellers, Ph.D., M.P.H., Moffitt executive vice president and director of the Moffitt Research Institute. "Because women may vary in their ability to eradicate disease or tolerate treatment, genetic association studies like ours are needed to identify the genetic bases related to outcome. Until this study, GWAS have not uncovered any outcome-associated genetic traits for EOC."

The gene set analysis the researchers used in this study focused specifically on EOC survival data in the genome-wide association studies. According to Sellers, GSA helps to systematically narrow the search for relevant genes.

"Unfortunately, GSA does not allow us to determine the gene set's effect on outcome," explained Sellers. "GSA does, however, contribute to our understanding of the relationship between EOC genetic variation and mortality. Our results using GSA may lead to the discovery of other possible gene sets and novel genes related to EOC that can be followed up in future studies."


Contact: Ferdie De Vega
H. Lee Moffitt Cancer Center & Research Institute

Related medicine news :

1. Researchers discover possible approach to the treatment of aggressive breast cancer
2. Researchers ID gene behind primary cervical dystonia, a neck-twisting disorder
3. Researchers find sarcoma tumor immune response with combination therapy
4. Mayo researchers provide atomic view of a histone chaperone
5. Researchers find potential solution to melanomas resistance to vemurafenib
6. Kessler Foundation researchers present at DC Conference on Race, Ethnicity and Disabilities
7. Researchers Spot Genes Behind Macular Degeneration
8. 90 percent of firefighters exhibit symptoms of PTSD according to Ben-Gurion University researchers
9. New blood test for early cancer detection developed by Ben-Gurion University researchers
10. UC Davis MIND Institute researchers to present on autism at AAAS Annual Meeting in Vancouver
11. Nasty superbug is being studied by UB researchers
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... Healthjump, Inc. announced ... a Healthcare IT consulting, development and support company. The purchase will expand the ... within DataTrade to extend the services currently provided by Healthjump. , ...
(Date:11/30/2015)... Maryland (PRWEB) , ... November 30, 2015 , ... ... interactions could be of critical importance to the medical schools of the future. ... exhibited its healthcare suite at the 2015 ChangeMedEd conference in Chicago, organized by ...
(Date:11/30/2015)... ... 30, 2015 , ... TransPack Volume 6 features 30 customizable transitions created exclusively ... transitions to wipes with blur & drop shadow options. Utilize the controls in ... one clip to the next with TransPack's easily customizable styles. , TransPack ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... worldwide today released the results of a survey of educational needs for pharmacists ... found a growing global demand for high quality online and face-to-face education for ...
(Date:11/30/2015)... , ... November 30, 2015 ... ... to announce their strategic partnership at the Radiological Society of North America ... Winscribe, global providers of cutting-edge dictation and speech-enabled documentation software, announced their ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 ... aanpak combineert immunotherapie met Bremachlorin-photodynamische therapie voor ... ) --> ... ) Uit ... Centrum (LUMC) blijkt ...
(Date:11/26/2015)... -- 3D bioprinting market is expected to ... report by Grand View Research Inc. Rising prevalence of chronic ... transplantation is expected to boost the market growth, as 3D ... --> 3D bioprinting market is expected to ... report by Grand View Research Inc. Rising prevalence of chronic ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the Global Cell Surface Testing ... Opportunities" report to their offering.  ... the addition of the  "2016 Future ...
Breaking Medicine Technology: