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Researchers find pathway that drives spread of pediatric bone cancer in preclinical studies
Date:10/25/2010

s found that HDAC inhibitors actually increased the Notch pathway in osteosarcoma cells that had low Hes1 expression, which was an unfavorable response in that sample group. However, for cells that presented with high Hes1 expression, where Notch was already maximized, the HDAC inhibitors led to osteosarcoma cell death.

"By defining vital signaling pathways in bone sarcomas, we hope small molecule inhibitors can be applied, leading to longer survival and reducing morbidity and late effects from intensive chemotherapy," said Hughes.

"We also hope these new findings may apply to other solid tumors such as breast, prostate, colon and more, but we'll need additional research to determine whether or not that is the case," he added.


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Contact: Sara Farris
sfarris@mdanderson.org
713-792-9133
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

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Researchers find pathway that drives spread of pediatric bone cancer in preclinical studies
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