Navigation Links
Researchers find no difference in drugs for macular degeneration
Date:9/30/2010

(Boston) Researchers from Boston University School of Medicine (BUSM) and the VA Boston Healthcare System have conducted a study that failed to show a difference in efficacy between Bevacizumab (Avastin) and Ranibizumab (Lucentis) for the treatment of age-related macular degeneration (AMD). The study, which appears currently on-line in Eye, is believed to be the first study to describe one-year outcomes of a prospective, double-masked, randomized clinical trial directly comparing bevacizumab to ranibizuamab. Last October, these same researchers published early, six month outcomes of the same study, which also failed to show a difference in efficacy between these two drugs for treating AMD.

AMD is the leading cause of blindness over the age of 50 in developed Western countries. It presents in two forms, exudative (wet) or nonexudative (dry). Wet AMD is often more visually devastating with a higher risk of blindness. The gold standard of treatment for wet AMD is ranibizumab (Lucentis, Genentech Inc.), which was FDA approved as an eye injection in 2006. Bevacizumab (Avastin, Genentech Inc.) was FDA approved for the treatment of colorectal cancer in 2004, but has also been used worldwide in an off-label fashion as an eye injection for the treatment of wet AMD. Lucenitis costs approximately $2000.00 per injection, while Avastin costs approximately $50.00 per injection. While both drugs have shown independently to be effective in treating wet AMD, it was uncertain if both drugs were equally efficacious or if either one was better.

In this study, patients were enrolled by a 2:1 ratio to receive either the Avastin or Lucentis. Patients were given eye injections of Avastin or Lucentis every month for the first three months, followed by monthly examination and testing. They received further injections on an as needed basis for one year.

Fifteen patients received Avastin and seven patients received Lucentis. There was no significant difference in visual acuity and anatomic outcomes between the two groups. Both groups had an average improvement in vision of 1.5 lines on the vision testing chart, and only one patient (who was in the Lucentis group) lost a significant amount of vision (three lines or more). In addition, patients in the Avastin group underwent an average of eight injections over one year, while patients in the Lucentis group underwent an average of four injections.

"With the exception that total injections given to subjects over one year were significantly different between the two treatment arms, visual and anatomic outcomes at one year failed to show a significant difference between both groups," said lead author and Principal Investigator Manju Subramanian, MD, an assistant professor in Ophthalmology at BUSM. According to the authors, further studies with larger sample sizes are warranted.


'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. Researchers advance biosynthesis of potent anti-cancer drug Taxol
2. Researchers engineer microbes for low-cost production of anti-cancer drug, Taxol
3. Researchers at the University of Granada associate trigger points with shoulder injury
4. Researchers to study effects of Mass. health reform
5. IU researchers: Chemotherapy alters brain tissue in breast cancer patients
6. Researchers use CT to predict heart disease
7. VCU study: Researchers discover a drug combination that shrinks tumors in vivo
8. Sugary sports drinks mistakenly associated with being healthy, say UTHealth researchers
9. Researchers create first molecule blocks key component of cancer genes on-off switch
10. Researchers create first molecule-blocks key component of cancer genes on-off switch
11. Team of researchers finds possible new genetic risk for Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2017)... ... September 21, 2017 , ... Demonstrating ... governmental public health departments have been awarded five-year accreditation status through the ... benefits of being served by a PHAB-accredited health department now extend to ...
(Date:9/21/2017)... Southborough, Mass. (PRWEB) , ... September 21, 2017 , ... ... for children with autism, announced today the election of Yie-Hsin Hung to the Board ... Yie-Hsin Hung join our Board of Directors. Ms. Hung is an invaluable addition to ...
(Date:9/21/2017)... ... September 21, 2017 , ... FlipBelt, the fitness brand that specializes ... to the athletic wear market with the launch of their FlipBelt Crops. , The ... essentials securely at their fingertips while at the gym, on the trail, or on-the-go. ...
(Date:9/20/2017)... ... September 20, 2017 , ... Reflections Recovery Center, a ... by The Joint Commission for chemical dependency and behavioral health services. , The ... care organizations that meet the commission’s rigorous standards. Accreditation by The Joint Commission ...
(Date:9/20/2017)... GLENDALE, Calif. (PRWEB) , ... September 20, 2017 ... ... 15th year of providing a voice for people who have kidney disease. The ... many writers to share their stories. Entrants needed to meet only one ...
Breaking Medicine News(10 mins):
(Date:9/5/2017)... , Sept. 5, 2017  Getinge, a ... created a vibrant charitable donation program -- "Color ... support congenital heart defect research by The Children,s ... and the general public are encouraged to download ... submit the completed artwork to the gallery on ...
(Date:9/1/2017)... N.J. , Sept. 1, 2017  Bayer will present ... the European Society for Medical Oncology (ESMO) 2017 Congress, September ... presented will include new preclinical and clinical data on Bayer,s ... two earlier pipeline projects. ... the best minds in cancer research at ESMO," said ...
(Date:8/28/2017)... 2017   Aesculight ®, a division of LightScalpel ®, LLC, ... Built on over 20 years of American veterinary laser surgery innovation, Aesculight® ... VetScalpel®Features and Enhancements ... excising a tumor with his new VetScalpel laser. Dr. Duclos practices veterinary ... ...
Breaking Medicine Technology: