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Researchers find new way to block destructive rush of immune cells
Date:1/14/2008

ty Seed Grant.

In the next phase, the team will seek to develop better-targeted, anti-integrin therapies, with MyH9 among the rational targets for new classes of drugs. Toward that end, experiments currently underway are designed to determine which molecules regulate MyH9 activity during T cell migration.

Initial clinical studies on T cell migration focused on overall blocking of migration, but general inhibition is a blunt tool, said Tim Mosmann, Ph.D., director of the David H. Smith Center for Vaccine Biology and Immunology. As studies such as Dr. Kims help us to understand the process more precisely, we should be able to design much more precise methods to block migration in the selected circumstances that cause problems, without crippling the essential immune responses to infections.


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Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

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