Navigation Links
Researchers find new way to block destructive rush of immune cells
Date:1/14/2008

cell let go. Without precise changes that enable the front end to gain traction, and the tail to let go, the cell cannot migrate.

Kims team found that a subset of integrins, including lymphocyte functionassociated antigen-1 (LFA-1), control whether or not the tail end of the T cell can let go (de- adhesion). Data revealed for the first time that a protein called non-muscle myosin heavy chain-IIA (MyH9) is recruited to LFA-1 at the trailing end of migrating T lymphocytes. Experiments that interfered with the association between MyH9 and the LFA-1 integrin were found to prevent the trailing edge of the crawling T cell from letting go, dramatically reducing the ability of T cells to move. Myosins are motor proteins that expend energy to enable cell skeletons to contract. That contraction creates force that is used in many cases to move muscle fibers, but in the case of MyH9, to rip the trailing end of a migrating T cell foot away from the surface it is migrating across by breaking integrin-ICAM bonds. The results provide the first evidentiary support of the longstanding theory that cell skeleton contractile force is used to drive T cell migration, with MyH9 as the mechanical link. Captured images show fluorescently tagged actin (which partners with LFA-1 to grip the surface) gathering at the front end of the cell, and fluorescently tagged MyH9 gathering at the tail end in cycles, each time the cell takes a step.

The study was a joint effort by the Department of Surgery at Rhode Island Hospital, Brown Medical School, the Department of Physics at Brown University, the CBR Institute for Biomedical Research at Harvard Medical School and the departments of Chemical Engineering, Biomedical Engineering and Department of Microbiology and Immunology at the University of Rochester. The project was supported by the American Heart Association, the Rhode Island Foundation, the National Institutes of Health, the National Science Foundation and the Brown Universi
'/>"/>

Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. U of M researchers create beating heart in laboratory
2. Researchers challenge previous findings regarding widely used asthma treatment
3. UT Health Science Center researchers decoding saliva to detect breast cancer
4. Protein power: Researchers trigger insulin production in diabetic mice
5. Researchers use neuroimaging to study ESP
6. UGA researchers receive $9 million in grants to study barriers to effective addiction treatment
7. Researchers seek to make cavity-causing bacteria self-destruct
8. Human factors researchers test voting systems for seniors that can improve voting accuracy and speed
9. New research tools are too complex for easy answers, researchers say
10. In largest U.S. Hep C trial, researchers determine weight-based dosing is key to optimal treatment
11. U of M researchers discover fast-acting cyanide antidote
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... By Steven Reinberg ... -- A device intended to help with weight loss by ... to meet expectations in a trial among obese patients. ... between the brain and stomach, researchers hoped to suppress feelings ... they anticipated. "A device that safely blocks the nerve ...
(Date:9/2/2014)... HealthDay Reporter TUESDAY, ... outbreak continues to overwhelm health-care workers in three West ... the United Nations called on Tuesday for a concerted ... often-fatal virus. Dr. Thomas Frieden, director of the ... without a greater global commitment in resources -- both ...
(Date:9/2/2014)... ALEXANDRIA, VAThe latest research on sleep apnea, tonsillectomies, ... otolaryngic topics will be presented in Orlando, FL, ... OTO EXPO℠ of the American Academy of OtolaryngologyHead ... meeting of ear, nose, throat, head and neck ... research to be presented were released today, and ...
(Date:9/2/2014)... When weather conditions are right, tornadoes can occur ... a path of destruction. In fact, the United States leads ... tornadoes per year. Rainbow International offers the following safety tips ... , Select a safe place such as ... with no windows to stay during the storm. If a ...
(Date:9/2/2014)... Ticket Down is a reputable source for ... will be an exciting week for soccer fans in the ... and Bolivia will battle on U.S. soil in friendly exhibition ... 5th - September 9th: , Brazil vs. Ecuador Tickets ... Mexico vs. Chile Tickets at Levi's Stadium on Saturday, ...
Breaking Medicine News(10 mins):Health News:Nerve Blocking Procedure Fails to Impress in Weight Loss Study 2Health News:Nerve Blocking Procedure Fails to Impress in Weight Loss Study 3Health News:More Global Help Needed to Fight Ebola Outbreak 2Health News:More Global Help Needed to Fight Ebola Outbreak 3Health News:Act Quickly in Case of Tornado: Rainbow International® Offers Tips on How to Be Prepared for a Tornado 2Health News:Ticket Down Substantially Slashes Ticket Prices on Brazil vs. Ecuador Tickets, Brazil vs. Colombia Tickets, Mexico vs. Chile Tickets and Mexico vs. Bolivia Tickets 2Health News:Ticket Down Substantially Slashes Ticket Prices on Brazil vs. Ecuador Tickets, Brazil vs. Colombia Tickets, Mexico vs. Chile Tickets and Mexico vs. Bolivia Tickets 3
... said, ‘Self-critical adult who are prone to depression and anxiety, ... abused environment in their childhood years’. ,Verbally abused ... depression and anxiety as those who had not been verbally ... 54, conducted by Florida State University researchers revealed. ...
... Mr.Manmohan Singh today met representatives of the medical students ... The students came from institutions inside Delhi and across the ... demands which they wanted the Prime Minister and the government ... of their fellow students. ,The Prime Minister assured ...
... Health and Family Welfare Department into two wings, namely ... to allow for streamlined health services. ,State ... the step was being taken to ensure that specialist ... will ask 23 doctors who were on deputation with ...
... A politician's daughter in South Africa was embroiled in ... drugs in favour of a diet containing// garlic, olive ... believed to increase the lifetime of HIV victims’, said ... Treatment Action Campaign (TAC), said ‘Instead of objective decision-making ...
... Human Reproduction, researchers have established the first direct ... fertilization and Placenta Previa, a potentially dangerous complication ... a condition in which the placenta covers the ... baby’s passage in the birth canal. ...
... North Tripura district have been suffering from AIDS and 12 ... ,This was found in a survey at the ... ,The department collected blood samples of 120 inmates of ... HIV positive, the sources said., ,Refugee leader R Bhanglo, ...
Cached Medicine News:Health News:Link Established—Assisted Fertilization Can Complicate Pregnanc 2
(Date:9/2/2014)... York , September 2, 2014 ... published by Transparency Market Research "Latin America Home ... Devices, Therapeutic Home Healthcare Devices, Mobility Assist Devices ... Telemedicine, Respiratory Therapy, Infusion Therapy and Unskilled Home ... Trends and Forecast, 2014 - 2020" the Latin ...
(Date:9/2/2014)... -- According to the new market research ... by Material (Metal, Glass, Plastic), by Application [GC, LC ... published by MarketsandMarkets, the Chiral Chromatography Columns Market was ... grow at a CAGR of 5.2% from 2013 to ... 90 market data tables and 15 figures spread through ...
(Date:9/2/2014)... Calif. , Sept. 2, 2014  Avanir Pharmaceuticals, Inc. ... will present an overview of the company at the Morgan ... . , Presentation date: Tuesday September 9, 2014 ... A live webcast and 30-day archive of this presentation ... About Avanir Pharmaceuticals, Inc. Avanir Pharmaceuticals, Inc. is ...
Breaking Medicine Technology:Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 2Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 3Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 4Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 5Home Healthcare Market in Latin America Expected to Reach USD 17.5 Billion in 2020: Transparency Market Research 6Chiral Chromatography Column Market Worth $87.8 Million by 2018 2Chiral Chromatography Column Market Worth $87.8 Million by 2018 3Chiral Chromatography Column Market Worth $87.8 Million by 2018 4
... FRANCISCO, Calif., Aug. 25, 2011 Rigel Pharmaceuticals, Inc. ... M. Gower, chairman and chief executive officer, and Ryan ... Rigel, will present at two separate investor conferences in ... Healthcare Conference 2011Date: Thursday, September 8th at 10:20 a.m. ...
... Nutrastar International Inc. (OTCBB: NUIN; "Nutrastar" or the "Company"), ... Chinese Medicine ("TCM") consumer products, today announced that its ... under which Nutrastar may repurchase up to US$5 million ... 12 months. Under the program, the ...
Cached Medicine Technology:Nutrastar Announces Adoption of Share Repurchase Program 2Nutrastar Announces Adoption of Share Repurchase Program 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: