Navigation Links
Researchers find new way to block destructive rush of immune cells
Date:1/14/2008

r Vaccine Biology and Immunology at the Medical Center, and lead author of the article. Good examples include when our immune system attacks our own cells, or rejects a lifesaving transplant or clogs our blood vessels by mistake. The problem is that past, system-wide attempts that block all integrin activation, like the multiple sclerosis drug Tysabri, shut down not only unwanted inflammation in one locale, but also vital immune defenses elsewhere, leaving patients vulnerable to infection.

The Great Migration

Two mechanisms make cell migration, or programmed directional movement, possible. The first, called chemotaxis, tells the cell which direction to move in. Cell surface proteins sense and follow chemicals and molecules they are attracted to toward wherever those attractants are most concentrated. T cells, named after the thymus (T) where they mature, move toward the byproducts of bacteria and viruses.

The second migratory mechanism is propulsion. In between infections and injuries, inactive T cells ride along with the bloodstream. T cells realize when they pass by part of a blood vessel wall close to the site of an injury or infection. Integrins on their surfaces unfold and grab onto key proteins on the surface of blood vessel wall cells (e.g. ICAM), resisting the surrounding blood flow. The T cells then pass through the vessel wall, and once outside the bloodstream, crawl along the tissue scaffolding toward the site of injury.

In a T cell at rest, integrins are distributed evenly over the entire surface of the T cell. When the cell gets ready to move, however, activated integrins cluster on the leading edge of the cell in the direction the cell wants to move in. They bind to their counterpart adhesion proteins like ICAM on the surface that the T cell is moving across. The T cell then contracts using its cell skeleton to pull itself over the leading edge integrins. Finally, the integrins on the trailing edge of the
'/>"/>

Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. U of M researchers create beating heart in laboratory
2. Researchers challenge previous findings regarding widely used asthma treatment
3. UT Health Science Center researchers decoding saliva to detect breast cancer
4. Protein power: Researchers trigger insulin production in diabetic mice
5. Researchers use neuroimaging to study ESP
6. UGA researchers receive $9 million in grants to study barriers to effective addiction treatment
7. Researchers seek to make cavity-causing bacteria self-destruct
8. Human factors researchers test voting systems for seniors that can improve voting accuracy and speed
9. New research tools are too complex for easy answers, researchers say
10. In largest U.S. Hep C trial, researchers determine weight-based dosing is key to optimal treatment
11. U of M researchers discover fast-acting cyanide antidote
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... CA (PRWEB) May 22, 2015 ... lower thirds designed exclusively for Final Cut Pro X. ... with any design. , Intuitive on-screen-controls allow users ... lower third. Reflections, colors, layouts, and much more can ... window. , Pro3rd Impression comes packed ...
(Date:5/21/2015)... WellCare Health Plans, Inc. (NYSE: WCG) announced ... the Florida Healthy Kids Corporation (FHKC) to continue to provide ... part of the Florida Healthy Kids (FHK) program. Pending execution, ... may be extended for two additional years at FHKC’s discretion. ... the FHK program who live in Regions 1, 2, 3, ...
(Date:5/21/2015)... May 21, 2015 ChiliPad ... temperature of each side of the bed so that ... on either side of the bed can pick their ... them fall asleep faster and stay asleep longer. , ... water to regulate the temperature which produces a more ...
(Date:5/21/2015)... May 21, 2015 The ThedaCare Center for ... new full-time role as president. Barnas is based in Appleton ... focus is to coach, lead and support Center teams that ... , Transforming the patient experience , Making ... across North America. , The Center is excited ...
(Date:5/21/2015)... Shimadzu Scientific Instruments today announces the ... new time-saving tools to maximize laboratory productivity. In ... and solid-phase microextraction (SPME), the AOC-6000 features a ... to seamlessly change injection techniques before starting the ... autosampler allows for sample preparation to be completely ...
Breaking Medicine News(10 mins):Health News:Developers at Pixel Film Studios Release Pro3rd Impression for Final Cut Pro X. 2Health News:WellCare Selected to Continue Participating in the Florida Healthy Kids Program, Will Serve Nine Florida Regions Under the New Contract 2Health News:ChiliPad, a Dual-Zone Temperature-Controlled Mattress Pad, Promotes Better Sleep, Health Benefits, and Saves on Cooling Costs in Upcoming Hot Summer Weather 2Health News:ChiliPad, a Dual-Zone Temperature-Controlled Mattress Pad, Promotes Better Sleep, Health Benefits, and Saves on Cooling Costs in Upcoming Hot Summer Weather 3Health News:Kim Barnas joins ThedaCare Center for Healthcare Value 2Health News:Shimadzu’s New AOC-6000 Autosampler Makes Automated Sample Introduction Simple and Efficient 2
... The Harvard Graduate School of Education ... help academic leaders, practitioners and faculty improve educational practices ... the Mind, Brain, and Education institute will explore ... how it functions can improve the educational process. ...
... PA, April 23, 2009 During the past several ... genes for nicotine dependence through genetic linkage and association ... been associated with tobacco smoking, only a very limited ... How to find these functional variants and then characterize ...
... Inc. announces the launch of a new menopausal cooling towel ... , ... Key West, FL (Vocus) April 23, 2009 -- CHILL International, Inc. ... provides instant relief for hot flashes and night sweats . ...
... in number of facilities offering weight loss surgery, ... Medical centers offering surgical weight loss programs ... and it,s more important than ever to know ... affiliated health plans undergoing weight loss surgery at ...
... of Washington state business, academic, government and community leaders ... effort to enhance the public,s understanding of the economic ... the growth and success of the sector. We ... an Archstone Consulting study on the economic impact of ...
... -- InfoLogix, Inc. ... technology provider of enterprise mobility solutions for the ... has entered into an agreement with Gwinnett ... based in suburban Atlanta, to deploy a next-generation, ...
Cached Medicine News:Health News:Bringing Brain Science to the Classroom 2Health News:Throwing the micro switch: MicroRNA may link smoking risk gene to neurobiology of addiction 2Health News:Chill Cooling Towels Introduces Instant Relief for Hot Flashes and Night Sweats 2Health News:Chill Cooling Towels Introduces Instant Relief for Hot Flashes and Night Sweats 3Health News:Patients Had Fewer Infection Rates, Fewer Complications at Blue Distinction Centers for Bariatric Surgery(R), According to HealthCore Study 2Health News:Patients Had Fewer Infection Rates, Fewer Complications at Blue Distinction Centers for Bariatric Surgery(R), According to HealthCore Study 3Health News:Patients Had Fewer Infection Rates, Fewer Complications at Blue Distinction Centers for Bariatric Surgery(R), According to HealthCore Study 4Health News:Business, Life Sciences Leaders Launch 'We Work for Health' Economic Development and Jobs Campaign in Washington State 2Health News:Business, Life Sciences Leaders Launch 'We Work for Health' Economic Development and Jobs Campaign in Washington State 3Health News:Business, Life Sciences Leaders Launch 'We Work for Health' Economic Development and Jobs Campaign in Washington State 4Health News:Business, Life Sciences Leaders Launch 'We Work for Health' Economic Development and Jobs Campaign in Washington State 5Health News:InfoLogix Selected by Gwinnett Medical Center to Transform Clinical Care Through Next-Generation Mobile Communications Solution 2Health News:InfoLogix Selected by Gwinnett Medical Center to Transform Clinical Care Through Next-Generation Mobile Communications Solution 3
(Date:5/21/2015)... 21, 2015  When Ryan Rendino first ... of his neck, he figured it was ... weeks off from weight lifting. ... A series of doctor ... to Michel Kliot, MD , a ...
(Date:5/21/2015)... Research and Markets ... of the "Arthroscopy Devices Markets Worldwide" ... http://photos.prnewswire.com/prnh/20130307/600769) , ,The purpose of this report ... market for Arthroscopy Devices. The report discusses ... market for these products. , ,Product - ...
(Date:5/21/2015)... ANDOVER, Mass. , May 21, 2015 /PRNewswire/ ... into the Electronic Health Record (EHR) is invaluable ... ICU. Though EHRs are now a requirement and ... to and continuously into the EHR is gaining ... Software Exchange), William Holmes, RN, Site Project Manager ...
Breaking Medicine Technology:Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 2Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 3Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 4Analysing Arthroscopy Devices Markets Worldwide 2014-2020 2Analysing Arthroscopy Devices Markets Worldwide 2014-2020 3Hospital Streamlines ICU Efficiency with Timely Data Integration 2Hospital Streamlines ICU Efficiency with Timely Data Integration 3
... HYCOR Biomedical, Inc., a leading manufacturer and marketer ... has signed an agreement with Eurospital—a manufacturer of pharmaceutical ... in all countries covered by the patent (excluding the ... disease. HYCOR today also announced that it has signed ...
... Encompassing virtually every aspect of modern cancer management, Elekta ... breadth of its offerings, but its commitment to maximize safety ... The conference will convene July 31 - August 4 in ... of the most effective ways to treat cancer today," says ...
Cached Medicine Technology:HYCOR Broadens Diagnostic Offerings, Announces Agreements to License Biomarkers for Celiac Disease and Rheumatoid Arthritis 2Elekta Emphasizes Commitment to Safety in Cancer Management at Joint Radiation Physics Annual Meeting 2Elekta Emphasizes Commitment to Safety in Cancer Management at Joint Radiation Physics Annual Meeting 3
... mid-sized chest freezer utilizes ultra-thin vacuum ... capacity without increasing the footprint. Patented ... extends compressor life. Bright LED display ... provided for remote user-supplied monitoring system. ...
... The NU-5510 DHD AutoFlow Direct Heat ... filtration guarantying the greatest control of ... both at 95C wet decontamination and ... exceptionally useful for cell line changes ...
... uses ultra-thin vacuum insulation panel technology, ... to increase storage capacity, while maintaining ... boxes or 3,336 samples. Patented heat ... consumption and extends compressor life. Temperature ...
... Series CO2 Incubators by Cedco ... achieves precise temperature and CO2 ... & RH% is displayed digitally. ... RH are displayed digiton large, ...
Medicine Products: