Navigation Links
Researchers find new way to attack inflammation in Graves' eye disease
Date:11/6/2009

Ann Arbor, Mich. A small group of patients with severe Graves' eye disease experienced rapid improvement of their symptoms and improved vision following treatment with the drug rituximab. Inflammation around their eyes and damage to the optic nerve were significantly reduced. The same patients had not previously responded to steroids, a common treatment for Graves' eye disease.

Raymond S. Douglas, M.D., Ph.D., an oculoplastics specialist who recently joined the faculty of the U-M Kellogg Eye Center, reports on the potential of the drug in the online October issue of Ophthalmology. Douglas reviewed the progress of six patients he treated while on the faculty of the University of California at Los Angeles.

Graves' eye disease is an autoimmune disease that causes inflammation and fatty deposits in the eye muscles and connective tissue surrounding the eye. Among the symptoms are pronounced bulging eyes, retracted eyelids, dry eyes, and, in severe cases, loss of vision. Women are more likely than men to develop the disease.

The study suggests that rituximab is a potentially effective new treatment for the most severe forms of Graves' eye disease. "These patients had already received the maximum level of steroid treatment," says Douglas. "Treatment with rituximab calmed inflammation, stopped progression of the disease, and saved the patients from having to undergo surgery."

Rituximab has been used to treat patients with other autoimmune diseases, including rheumatoid arthritis and in non-Hodgkin's B-cell lymphoma. The drug works by depleting B cellsthe body's normal antibody-producing cellsthat appear to go awry in autoimmune diseases.

Collaborating with Terry J. Smith, M.D., the Frederick G.L. Huetwell Professor of Ophthalmology and Visual Sciences, Douglas has helped to explain the process by which the immune system attacks the orbital tissue in Graves' eye disease. In an earlier study, the researchers report
'/>"/>

Contact: Betsy Nisbet
bsnisbet@umich.edu
734-647-5586
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Jefferson researchers receive $3.9 million in Challenge grants
2. Childhood cancer survivors less likely to marry, Yale researchers find
3. Researchers unlock the sound of learning by linking sensory and motor systems
4. Researchers identify the 3 killer indicators that are even worse than high cholesterol
5. Researchers discover links between city walkability and air pollution exposure
6. High-definition colonoscopy detects more polyps, Mayo Clinic researchers say
7. Researchers find room design can enhance patient care
8. UC San Diego researchers reverse pulmonary arterial hypertension in mouse models
9. No elder left behind: Researchers say designers can help close tech gap
10. Manipulating brain inflammation may help clear brain of amyloid plaques, Mayo Clinic researchers say
11. Researchers exploit genetic co-dependence to kill treatment-resistant tumor cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Unidesk Corporation today announced that the ... its inaugural class in August 2013, has successfully ... bring your own device (BYOD) and deliver a ... solution, comprised of Citrix XenDesktop and ... storage infrastructure and Unidesk virtual desktop ...
(Date:12/17/2014)... December 17, 2014 HeartMath® Inc., ... on stress, heart rate variability (HRV), heart coherence ... its extensive HRV databases and algorithms to chipset ... will enable HeartMath’s partners to offer its HRV ... research, as well as its normative HRV databases ...
(Date:12/17/2014)... Appleton, WI (PRWEB) December 17, 2014 ... Benefit Administrators and its Argus Claim Review division ... two of the most common ways savings are achieved ... administrator (TPA) attributes millions of dollars in savings to ... saved in 2013. , As explained by Tom Doney, ...
(Date:12/17/2014)... 17, 2014 Now in its second ... best of the best in senior living and home ... given to communities and agencies that have received outstanding ... Of the nearly 100,000 providers currently listed on SeniorAdvisor.com, ... the SeniorAdvisor.com Best of 2015 Awards are located all ...
(Date:12/17/2014)... gas prices rose in recent years, so did motorcyclist ... times of gas increases, more people start using motorcycles ... explained. They examined data gathered between 2002 and ... motorcycle registrations in the United States and the third ... a strong association between rising gas prices and an ...
Breaking Medicine News(10 mins):Health News:Alabama College of Osteopathic Medicine Deploys Desktop Virtualization Solution from Citrix, Dell and Unidesk 2Health News:Alabama College of Osteopathic Medicine Deploys Desktop Virtualization Solution from Citrix, Dell and Unidesk 3Health News:HeartMath® Inc.’s HRV Platform Solutions Available for Licensing 2Health News:HeartMath® Inc.’s HRV Platform Solutions Available for Licensing 3Health News:Out-of-Network & Medical Necessity Reviews among Top Ways TPA Identifies Significant Medical Claim Savings 2Health News:The Inn at Willow Falls - Crest Hill, IL Wins 2015 Best of Assisted Living Award from SeniorAdvisor.com 2Health News:The Inn at Willow Falls - Crest Hill, IL Wins 2015 Best of Assisted Living Award from SeniorAdvisor.com 3Health News:When Gas Prices Go Up, So Do Motorcycle Accidents, Study Finds 2
... and Forests has called for an action plan and ... National Workshop// on ‘Human - Leopard Conflict Management’ here ... need to have a re-look at our existing strategies ... one of the challenging issues facing wildlife managers in ...
... Assistant Professor Biswarup Mukhopadhyay has provided important information ... in the// December 22, 2006, Journal of Biological ... help researchers to identify potential targets for docking ... eliminate, the body's overproduction of glucose. ...
... viral culture system, which makes way for a better ... replication of virus// (isolated from patient) in non-transformed hepatocytes. ... in transformed cell lines. ,The study report ... transfected and serum-infected cultured human fetal hepatocytes,’ appears in ...
... novel analysis about the usage of cholesterol lowering drugs ... drug as a means to prevent heart disease; Researchers ... to lower life-threatening health risks for those suffering vascular ... beneficial in reducing the risk of heart attack and ...
... weapon in the war on cancer by targeting the human ... ,Two separate teams of researchers have found a ... that would otherwise stimulate the spread of the cancer. Although ... describing the approach as potentially one of the most important ...
... and Drug Administration has found that meat or milk from ... clones—is as safe to eat as food from// conventionally bred ... three documents regarding the safety of animal cloning—a draft risk ... for industry. ,Dr. Stephen F. Sundlof, director of ...
Cached Medicine News:Health News:VBI Provides Potential Targets to Diabetes Therapeutics 2Health News:A Breakthrough in the Study of Hepatitis C 2Health News:Cancer Scientists' Gene Research Offers New Treatment Hope 2Health News:FDA Finds Animal Cloned Food to Be Safe 2
(Date:12/15/2014)...   DaVita HealthCare Partners Inc.  (NYSE: ... and most innovative health care communities, today announced ... Clinical Research  (DCR) and  HealthCare Partners Clinical Research , ... clinical research and data analytics services, specifically in ... renal disease (ESRD), as well as primary care ...
(Date:12/14/2014)... S.C. , Dec. 14, 2014  ChartSpan, a ... the most downloaded iPhone and iPad medical app in ... Photo - http://photos.prnewswire.com/prnh/20141214/164317 ChartSpan ... the ability to request, manage and send electronic healthcare ... innovative entrepreneurs who grew tired of waiting for the ...
(Date:12/13/2014)... Dec. 12, 2014  Radiologists can transmit their ... to their referring physicians, electronic health records (EHR) ... selected technology.  That was the ... Corporation (ADS) at the recent Radiology Society of ... of radiology reports in this manner also helps ...
Breaking Medicine Technology:DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 2DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 3DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 4ChartSpan Becomes The Most Downloaded Medical App in America 2ChartSpan Becomes The Most Downloaded Medical App in America 3Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 2Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 3
... The Court of Appeals for the Federal Circuit has denied an ... a 2009 decision by the U.S. District Court of Delaware ... and not infringed by Andrx Corporation. , ... In December 2007 , McNeil Pediatrics, which markets CONCERTA, ...
... , AUSTIN, Texas , April 26 ... electronic health record (EHR) and practice management (PM) solutions, announced ... vendors by the Alaska EHR Alliance (AEHRA).   ... endorsed vendor to Alaska healthcare providers looking to ...
Cached Medicine Technology:CONCERTA(R) Patent Appeal Denied 2CONCERTA(R) Patent Appeal Denied 3Alaska EHR Alliance Selects e-MDs as Recommended Electronic Health Record Vendor 2Alaska EHR Alliance Selects e-MDs as Recommended Electronic Health Record Vendor 3Alaska EHR Alliance Selects e-MDs as Recommended Electronic Health Record Vendor 4
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: