Navigation Links
Researchers find new target for stopping tumors developing their own blood supply
Date:11/18/2010

Researchers have found that a newly developed drug, which is aimed at a particular receptor involved in the development of blood vessels that sustain tumour growth, is active in patients with advanced cancers and, in some cases, has halted the progress of the disease. The drug, ACE-041, targets a different molecular pathway to other anti-angiogenesis drugs and may provide a new option to treat cancer.

Results from a phase I clinical study of ACE-041 were presented at the 22nd EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Berlin today (Friday). The drug targets a receptor known as activin receptor-like kinase-1 (ALK-1), which regulates the formation of new networks of blood vessels needed for tumour growth a process known as angiogenesis. While existing anti-angiogenic drugs such as bevacizumab, sunitinib and sorafenib target other angiogenesis receptors such as VEGF, ACE-041 is one of the first to target the ALK-1 pathway.

Professor Sunil Sharma, the Jon and Karen Huntsman Presidential Professor of Cancer Research at the Huntsman Cancer Institute, University of Utah, Salt Lake City (USA), told the meeting that the connection of ALK-1 with angiogenesis was made with the discovery that mutations in the ALK-1 gene caused a condition known as hereditary haemorrhagic telangiectasia 2 (HHT2), which is characterised by impaired formation of capillary beds and causes red markings on the skin.

Acceleron Pharma, a biotechnology company in Cambridge, Massachusetts (USA), designed ACE-041 to inhibit ALK-1 signalling and asked Prof Sharma to be one of the investigators to conduct the first-in-man phase I clinical trial of the drug to see if it would inhibit tumour angiogenesis.

"Since ALK-1 is only transiently expressed on proliferating endothelial cells (the cells that line the inner surface of blood vessels), in contrast to the VEGF receptors which are constitutively expressed on endothelial and other c
'/>"/>

Contact: Emma Mason
wordmason@mac.om
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers identify PTSD measures for use in traumatic brain injury research
2. New insight into the cause of common dementia found by researchers at Mayo Clinic
3. Researchers fight Americas other drug problem
4. Researchers map the way to personalised treatment for ovarian cancer
5. Four NYU researchers receive New York Academy of Sciences 2010 Young Scientists awards
6. AAPS presents awards to exemplary researchers
7. Yerkes researchers present at 40th Annual Society for Neuroscience Conference
8. Researchers see ethical dilemmas of providing care in drug detention centers
9. Circuit regulating anti-diabetic actions of serotonin uncovered by UT Southwestern researchers
10. U of M researchers find learning in the visual brain
11. Researchers discover important link between adrenal gland hormone and brain in hypertension
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... ... ... TransPack Toon gives users a set of 90 cartoon transitions for ... 30 different styles. Presets range from snow, underwater, forest, futuristic, city and many more. ... 90 cartoon transitions from 30 unique styles. Editors can choose between line and ...
(Date:9/3/2015)... ... September 03, 2015 , ... E-Volve Health, an Elliot ... healthcare solutions organization, to provide electronic medical record (EMR) consulting services to Amerinet ... will receive negotiated pricing on E-Volve Health’s Epic EMR consulting, custom training and ...
(Date:9/3/2015)... ... 03, 2015 , ... DriButts, a non-profit organization dedicated to ... Development Group to manufacture a long-lasting reusable diaper for warm weather climates where ... bring 600 DriButts Diapers to rural areas of Haiti during a trip scheduled ...
(Date:9/3/2015)... (PRWEB) , ... September 03, 2015 , ... ... care community to be situated at 4400 Columbine Drive in Bellingham, Washington. Silverado ... 2016, and has been carefully designed to serve up to 80 people living ...
(Date:9/3/2015)... San Jose, CA (PRWEB) , ... September 03, ... ... high-performance Splashtop remote desktop solution for LANDESK Management Suite customers, as part of ... Management Suite’s user-centered approach to IT, by delivering the best mobile user experience ...
Breaking Medicine News(10 mins):Health News:Pixel Film Studios Releases TransPack Toon, a New FCPX Transition 2Health News:E-Volve Health to Offer EMR Consulting Solutions to Amerinet Members 2Health News:DriButts Diapers Rely on Slingshot Help in Haiti 2Health News:DriButts Diapers Rely on Slingshot Help in Haiti 3Health News:Site Dedication Ceremony to Celebrate New Silverado Memory Care Community 2Health News:Splashtop Partners with LANDESK to Deliver High Performance Remote Access and Remote Support to and from Mobile Devices and Chromebook 2Health News:Splashtop Partners with LANDESK to Deliver High Performance Remote Access and Remote Support to and from Mobile Devices and Chromebook 3Health News:Splashtop Partners with LANDESK to Deliver High Performance Remote Access and Remote Support to and from Mobile Devices and Chromebook 4
... just 3 to 5 hours sleep per night, study shows, , , ... teens is getting the recommended eight hours of sleep each night. ... help of highly-caffeinated energy drinks, according to new research. , ... teens polled reported falling asleep in school at least twice ...
... Chemical-Free Cleaning Process Offers Greater than 99.9 Percent Bacterial ... Pro, a convenient hand-held device that offers a breakthrough ... powerful general-purpose cleaner, has now been certified as a ... as directed, the Activeion Pro offers a greater than ...
... a considerable and largely undetected problemSAN FRANCISCO, May ... are away from work significantly longer than other ... by the non-profit Integrated Benefits Institute. The true ... payments and lost productivity -- are 2-1/2 times ...
... Holdings, Inc. (Pink Sheets: NXGH) is pleased to ... Billion Household and Industrial Cleaning Products Industry by ... a company which manufactures and distributes non-toxic, environmentally ... Green Bridge Industries in exchange for a combination ...
... --Data from Ongoing Glioblastoma Dosimetry Trial Accepted for ... Annual Meeting ----Over 65 Recurrent GBM Patients in ... Received Cotara to Date, with a Good Safety ... Calif., May 28 Peregrine Pharmaceuticals, Inc. (Nasdaq: ...
... of Tart Cherries May Help Relieve Post-Exercise Muscle Pain ... ease the pain for people who run, according to ... at the American College of Sports Medicine Conference in ... cherry juice while training for a long distance run ...
Cached Medicine News:Health News:Technology, Caffeine Keeping Teens Awake 2Health News:Technology, Caffeine Keeping Teens Awake 3Health News:Certified Lab Tests Confirm the Activeion Pro Is a Sanitizing Device 2Health News:Certified Lab Tests Confirm the Activeion Pro Is a Sanitizing Device 3Health News:IBI Research Finds Employers Severely Underestimate the Prevalence and Lost Productivity Costs of Depression 2Health News:IBI Research Finds Employers Severely Underestimate the Prevalence and Lost Productivity Costs of Depression 3Health News:NXGen Holdings, Inc. Enters the $17.5 Billion Household and Industrial Cleaning Products Industry through the Acquisition of Green Bridge Industries, Inc. 2Health News:Peregrine Pharmaceuticals Reports Progress in Cotara(R) Brain Cancer Clinical Program 2Health News:Peregrine Pharmaceuticals Reports Progress in Cotara(R) Brain Cancer Clinical Program 3Health News:Peregrine Pharmaceuticals Reports Progress in Cotara(R) Brain Cancer Clinical Program 4Health News:Peregrine Pharmaceuticals Reports Progress in Cotara(R) Brain Cancer Clinical Program 5Health News:Peregrine Pharmaceuticals Reports Progress in Cotara(R) Brain Cancer Clinical Program 6Health News:Is Cherry Juice a New 'Sports Drink?' 2
(Date:9/3/2015)... ALISO VIEJO, Calif. , Sept. 3, ... a leading global pharmaceutical company, and AqueSys, Inc. ... on developing ocular implants that reduce intraocular pressure ... have entered into an agreement under which Allergan ... the terms of the agreement, Allergan will acquire ...
(Date:9/3/2015)... Research and Markets ... the "Investigation Report on China,s Progesterone Market, ... The clinical demand for steroid drug is increasing ... efficacy especially its extended use in regulating human ... Progesterone, a natural progestogen produced by the ...
(Date:9/3/2015)... DUBLIN , Sep. 03, 2015 ... the addition of the "Investigation Report on China,s ... Developed by Genentech, trastuzumab was approved by FDA ... under the trade name of Herceptin, a major product ... was USD 6.56 billion around the world. After ...
Breaking Medicine Technology:Allergan to Acquire Glaucoma Treatment Company AqueSys to Add Minimally Invasive Implantable Shunt to Eye Care Offering 2Allergan to Acquire Glaucoma Treatment Company AqueSys to Add Minimally Invasive Implantable Shunt to Eye Care Offering 3Allergan to Acquire Glaucoma Treatment Company AqueSys to Add Minimally Invasive Implantable Shunt to Eye Care Offering 4Allergan to Acquire Glaucoma Treatment Company AqueSys to Add Minimally Invasive Implantable Shunt to Eye Care Offering 5Allergan to Acquire Glaucoma Treatment Company AqueSys to Add Minimally Invasive Implantable Shunt to Eye Care Offering 6China Progesterone Market Investigation Report 2015-2019 2Investigation Report on China's Trastuzumab (Genentech) Market, 2010-2019 2
... (Nasdaq: CDXS ) today announced the company will ... 2010 at 4:30 p.m. Eastern Time to discuss its third ...  The call and webcast will follow the release of third ... the call will be available approximately one hour after the ...
... Today the Roskamp Institute said that it is pleased ... RCP-006, a compound found in tobacco, for the treatment of ... a subsidiary of Star Scientific in Virginia, and made available ... In laboratory tests with cells, the compound, RCP-006, a ...
Cached Medicine Technology:Roskamp Institute to Begin Human Alzheimer's Clinical Trials With a Natural Compound in Tobacco 2
ACMI™ Distortion-Free Laparoscopes utilize technical advances in optical lens design to provide images without the fish-eye effect typically found on the peripheral viewing edges of conventional...
Stryker autoclavable pediatric laparoscopes provide equivalent brightness and resolution along with the unparalleled durability found in larger laparoscopes....
Inquire...
The flexible nature of the vinyl allows the user to reach deeper into the chamber and allows for a greater comfort when working inside the glove box over a long period of time compared to any rigid s...
Medicine Products: