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Researchers find new chemotherapy combination shows promise in endometrial cancer
Date:3/17/2010

ic examinations and imaging studies (computed tomography or magnetic resonance imaging) after every three cycles.

Of the 20 patients, two had a complete remission; eight had a partial response, or a decrease in the size of a tumor or in the extent of cancer in the body; six patients experienced a stabilization of disease, meaning their cancer neither decreased nor increased in extent or severity; and four experienced a progression in disease, meaning their tumor grew or cancer metastasized.

Findings demonstrated a 50 percent overall response rate, or improvement in disease. Additionally, the clinical benefit of the two-drug combination was 80 percent, as 16 of the 20 women experienced either an improvement or stabilization of disease. All side effects resulting from the therapy were manageable. Brown noted that results from the study warrant investigation of the chemotherapy combination in a larger, definitive trial at multiple institutions.

According to the National Cancer Institute, endometrial cancer is the most common gynecologic malignancy and the fourth most common cancer among women in the United States. Nearly 8,000 women died from the disease in 2009.

Gemcitabine and cisplatin in combination have been investigated extensively in other disease sites, and synergism of the two agents has been confirmed in cell lines of human endometrial, ovarian, colon, lung and squamous cell head and neck carcinomas.


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Contact: Lindsay Anderson
lindsay.anderson@gabbe.com
212-220-4444
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

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