Navigation Links
Researchers find gold nanoparticles capable of 'unzipping' DNA
Date:6/20/2012

New research from North Carolina State University finds that gold nanoparticles with a slight positive charge work collectively to unravel DNA's double helix. This finding has ramifications for gene therapy research and the emerging field of DNA-based electronics.

"We began this work with the goal of improving methods of packaging genetic material for use in gene therapy," says Dr. Anatoli Melechko, an associate professor of materials science and engineering at NC State and co-author of a paper describing the research. Gene therapy is an approach for addressing certain medical conditions by modifying the DNA in relevant cells.

The research team introduced gold nanoparticles, approximately 1.5 nanometers in diameter, into a solution containing double-stranded DNA. The nanoparticles were coated with organic molecules called ligands. Some of the ligands held a positive charge, while others were hydrophobic meaning they were repelled by water.

Because the gold nanoparticles had a slight positive charge from the ligands, and DNA is always negatively charged, the DNA and nanoparticles were pulled together into complex packages.

"However, we found that the DNA was actually being unzipped by the gold nanoparticles," Melechko says. The positively-charged ligands on the nanoparticles attached to the DNA as predicted, but the hydrophobic ligands of the nanoparticles became tangled with each other. As this tangling pulled the nanoparticles into clusters, the nanoparticles pulled the DNA apart. Video of the process is available at http://www.youtube.com/watch?v=9M-58niEOpU

"We think gold nanoparticles still hold promise for gene therapy," says Dr. Yaroslava Yingling, an assistant professor of materials science and engineering at NC State and co-author of the paper. "But it's clear that we need to tailor the ligands, charge and chemistry of these materials t
'/>"/>

Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers find gold nanoparticles capable of 'unzipping' DNA
(Date:8/22/2014)... Buying a policy for different life insurance products can ... coverage types by insurers in the U.S. The Quotes Pros ... the public using its sortable tool at http://quotespros.com/life-insurance.html . ... is expected to promote the discounts and special offerings for ... The system is designed to help an adult locate a ...
(Date:8/22/2014)... 22, 2014 The regional economy is ... is on the grow again. The plant ... summer 2016 to boost production of the popular Highlander ... Indiana’s overall investment to $4 billion. This step allows ... providing additional flexibility to adjust its product mix to ...
(Date:8/22/2014)... August 22, 2014 As the ... http://www.injurybeacon.com/power-morcellator/ ) in uterine surgeries continues to grow, ... companies have decided to limit coverage of uterine ... Telegram, Blue Cross-Blue Shield of Massachusetts will no ... involve morcellation as of September 1, 2014. Other ...
(Date:8/22/2014)... Bcl-2-like protein 11 (BIM) deletion in advanced ... shorter progression free survival (PFS) in epidermal growth ... chemotherapy treated Asian patients. Also, BIM deletion independently ... , The BIM protein can activate the programmed ... in cells. BIM deletion has been detected in ...
(Date:8/22/2014)... Las Vegas, NV (PRWEB) August 22, 2014 ... developed by Dr. Sen and Dr. Samantha Pearson to ... glasses, contacts, and avoid corrective vision surgery by instead ... Shane Michaels, prompting an investigative review. , “There’s ... billions of dollars in revenue each year—it’s because people ...
Breaking Medicine News(10 mins):Health News:Principal Life Insurance Policies Now Quoted for Adults at Insurance Website Online 2Health News:Toyota Indiana Adding 300 Jobs to Build More Highlanders 2Health News:As Power Morcellator Controversy Grows, Bernstein Liebhard LLP Comments on Massachusetts Insurers’ Plans to Limit Coverage of Uterine Morcellation 2Health News:As Power Morcellator Controversy Grows, Bernstein Liebhard LLP Comments on Massachusetts Insurers’ Plans to Limit Coverage of Uterine Morcellation 3Health News:As Power Morcellator Controversy Grows, Bernstein Liebhard LLP Comments on Massachusetts Insurers’ Plans to Limit Coverage of Uterine Morcellation 4Health News:Deletion predicts survival in advanced non-small cell lung cancer 2Health News:Restore My Vision Today: Review Exposes Natural Eye Restoration Guide by Dr. Sen and Dr. Samantha Pearson 2
... 17 Addus HomeCare Corporation announced today that it has filed ... Exchange Commission (SEC) relating to a proposed initial public offering of ... and the price range for the offering have not yet been ... be offered by Addus HomeCare Corporation. , ...
... ... (TRACK™) is the first validated, parent-administered asthma-control test for preschool-aged children , ... Wilmington, DE (PRWEB) July 17, ... simple questions to determine if their child,s breathing problems are not under control. AstraZeneca ...
... , , WASHINGTON, July 17 ... nurses today hailed passage of a key amendment in the ... bill this morning that would enable individual states to go ... , Introduced by Rep. Dennis ...
... Could be targets for new treatments, researchers say , FRIDAY, ... genetic variants associated with high blood pressure in black Americans ... treat this major risk factor for heart disease and stroke. ... of PLoS Genetics , is one of a series ...
... , Patient Advocates , Medicare Beneficiaries Visit ... Act, Oppose Additional Cuts to Oxygen Benefit , ... of Congress to support patient-focused reform of the Medicare home oxygen ... (NECA), a national advocacy organization representing patients with chronic obstructive pulmonary ...
... Mass., July 17 The Hanover Insurance Group (NYSE: THG ... availability of a new product offering that can extend homeowners coverage to ... , (Logo: http://www.newscom.com/cgi-bin/prnh/20051031/NEM023LOGO ... is more important than ever as the population of people residing in ...
Cached Medicine News:Health News:Addus HomeCare Corporation Files Registration Statement 2Health News:New Five-Question Test Helps Assess Asthma Control In Children Under Five Years Of Age 2Health News:New Five-Question Test Helps Assess Asthma Control In Children Under Five Years Of Age 3Health News:New Five-Question Test Helps Assess Asthma Control In Children Under Five Years Of Age 4Health News:RNs Praise House Vote to Permit State Single-Payer Laws 2Health News:RNs Praise House Vote to Permit State Single-Payer Laws 3Health News:Five Hypertension Genes Found in Black Americans 2Health News:Five Hypertension Genes Found in Black Americans 3Health News:Home Oxygen Patients and Family Members Visit Capitol Hill to Ask Congress to Protect Medicare Home Oxygen Therapy Benefit 2Health News:The Hanover Launches New Insurance Option to Protect Family Members in Assisted Living Facilities 2Health News:The Hanover Launches New Insurance Option to Protect Family Members in Assisted Living Facilities 3
(Date:8/21/2014)... /CNW/ - Eisai Limited is pleased to support the Canadian ... book available in Canada . The comic ... educate children and their parents about epilepsy, the most common ... than 300,000 Canadians. Eisai is guided by a corporate philosophy ... the patient is central – there was a need within ...
(Date:8/21/2014)... , Aug. 21, 2014 /PRNewswire-iReach/ -- ... Equipment, Inc. for the third straight year, No. ... 500|5000, an exclusive ranking of the nation,s fastest-growing ... look at the most important segment of the ... Timberland, Dell, Domino,s Pizza, LinkedIn, Zillow, and many ...
(Date:8/21/2014)...  Seventy-one percent of Americans believe the abuse of strong ... health and safety issue in the United States ... by Repass & Partners, a Cincinnati ... severity of the prescription medication abuse problem and the need ... health situation facing our country," Rex Repass , CEO ...
Breaking Medicine Technology:Eisai Pleased to Support Canadian Epilepsy Alliance Comic Book that Teaches Children About Epilepsy 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 3Consumers Desperate For Measures To Curb Prescription Drug Abuse 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 3
... Caremark (NYSE: CVS ) has been named ... by Reputation Institute, in partnership with Forbes Media. The ... RepTrak™ Pulse, a study that measures the 150 largest ... ) Of the companies included in ...
... -- American Oriental Bioengineering, Inc. (NYSE: AOB ) ... (the "NYSE") has notified the Company that it is not ... to timely file its Annual Report on Form 10-K with ... rules, when a Company does not comply with annual report ...
Cached Medicine Technology:CVS Caremark Ranks Among Top 25 Most Reputable Companies in America on Forbes List 2American Oriental Bioengineering Inc. Receives NYSE Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard 2
... of DOA Panel Test is ... in vitro test. It is ... substances in human urine specimens. ... in the point of care ...
... a qualitative immunoassay intended to ... usage of cocaine by detecting ... in human urine at a ... It is for health care,professional ...
The RapidBARBITURATE test is an immunochromatography based one step in vitro test. It is designed for qualitative determination of barbiturates and in human urine specimens above a cut-off level of 3...
... delivers performance, value and safety ... smaller laboratories. It's an affordable, ... small sample volume in both ... a wide operating range and ...
Medicine Products: