Navigation Links
Researchers find gold nanoparticles capable of 'unzipping' DNA
Date:6/20/2012

New research from North Carolina State University finds that gold nanoparticles with a slight positive charge work collectively to unravel DNA's double helix. This finding has ramifications for gene therapy research and the emerging field of DNA-based electronics.

"We began this work with the goal of improving methods of packaging genetic material for use in gene therapy," says Dr. Anatoli Melechko, an associate professor of materials science and engineering at NC State and co-author of a paper describing the research. Gene therapy is an approach for addressing certain medical conditions by modifying the DNA in relevant cells.

The research team introduced gold nanoparticles, approximately 1.5 nanometers in diameter, into a solution containing double-stranded DNA. The nanoparticles were coated with organic molecules called ligands. Some of the ligands held a positive charge, while others were hydrophobic meaning they were repelled by water.

Because the gold nanoparticles had a slight positive charge from the ligands, and DNA is always negatively charged, the DNA and nanoparticles were pulled together into complex packages.

"However, we found that the DNA was actually being unzipped by the gold nanoparticles," Melechko says. The positively-charged ligands on the nanoparticles attached to the DNA as predicted, but the hydrophobic ligands of the nanoparticles became tangled with each other. As this tangling pulled the nanoparticles into clusters, the nanoparticles pulled the DNA apart. Video of the process is available at http://www.youtube.com/watch?v=9M-58niEOpU

"We think gold nanoparticles still hold promise for gene therapy," says Dr. Yaroslava Yingling, an assistant professor of materials science and engineering at NC State and co-author of the paper. "But it's clear that we need to tailor the ligands, charge and chemistry of these materials to ensure the DNA's structural integrity is not compromised."

The finding is also relevant to research on DNA-based electronics, which hopes to use DNA as a template for creating nanoelectronic circuits. Because some work in that field involves placing metal nanoparticles on DNA, this finding indicates that researchers will have to pay close attention to the characteristics of those nanoparticles or risk undermining the structural integrity of the DNA.


'/>"/>
Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University
Source:Eurekalert  

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers find gold nanoparticles capable of 'unzipping' DNA
(Date:2/18/2017)... ... February 17, 2017 , ... CONTACT:, Glenn Vallecillos, MD, FACS, ... surgeon Dr. Glenn Vallecillos experiments SculpSure, the hot, new, aesthetic, non-surgical ... has been centered around that idea that to achieve ones desired results a ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... pace. Enovate Medical has introduced an innovative workstation designed to reduce nursing fatigue ... the Encore Mobile EHR Workstation offers a lightweight, highly mobile, multi-functional alternative to ...
(Date:2/17/2017)... , ... February 17, 2017 , ... ... Dr. Carol Francis' goals for each and every seminar, session and ... Francis will demonstrate five different brainwave tools which help energize creativity, focus mental ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... services, announced today that Karen Pilley has been promoted to Chief Executive Officer. ... today’s shifting healthcare paradigm – a shift that demands the transition from pay-for-service ...
(Date:2/17/2017)... ... February 17, 2017 , ... Top neuroendocrine cancer doctors, nurses and ... Summit from February 21 - 23 in Beaver Creek, CO. It was announced today ... Summit’s second year in Beaver Creek, hosting over 60 faculty members and addressing unmet ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... , Feb. 16, 2017 Absorption Systems, a ... medical devices, is pleased to announce that its Chief ... selected as a winner of the 2017 Executive Management ... and recognizes driven executives for their creative management ... The awards ceremony and celebration is on March 8, ...
(Date:2/16/2017)... Ontario , Feb. 16, 2017  Aralez Pharmaceuticals ... global specialty pharmaceutical company, today announced that executive management ... Conference to be held February 22-23, 2017. Adrian ... of the Company at 1:35 p.m. local time on ... and audio archive for the event may be accessed ...
(Date:2/16/2017)... NEW YORK , Feb. 16, 2017 ... and agreements entered into by the worlds leading healthcare companies. ... Description The Global ... access to partnering deals and agreements entered into by the world,s ... - Top deals by value - Deals listed by ...
Breaking Medicine Technology: