Navigation Links
Researchers find genetic tie to improved survival time for pulmonary fibrosis
Date:5/21/2013

AURORA, Colo. (May 21, 2013) Research into genetic features of pulmonary fibrosis by physicians and scientists at the University of Colorado School of Medicine may lead to improved treatment of this deadly lung disease, according to a paper published online by JAMA.

The study found that a particular genetic variation helps predict survival in some cases of pulmonary fibrosis, a chronic progressive disease with a median survival of three years. As a result of the study, researchers may want to consider including genetic testing in future clinical trials.

The researchers looked at whether the MUC5B promoter polymorphism, which previously was found to be associated with developing the disease, is also associated with survival time for individuals with pulmonary fibrosis. MUC5B is a protein that is a component of the mucous produced by the bronchial tubes. Pulmonary fibrosis is a condition where lung tissue becomes thickened, stiff and scarred.

The investigators found that genetic changes in the MUC5B gene are associated with marked improvement in survival among patients with pulmonary fibrosis. This represents the first genetic test that can be used to prognosticate in pulmonary fibrosis and may prove useful taking care of patients with this disease. Currently in the United States, there are no drugs approved for use in cases of the disease. This paper indicates that future drug trials should consider including this genetic test to determine the benefit of their intervention.

The research was supported by funding from the National Heart, Lung and Blood Institute and the Dorothy P. and Richard P. Simmons Endowed Chair for Pulmonary Research at the University of Pittsburgh School of Medicine. Twenty-two authors shared credit for the paper, including researchers from the University of Chicago, the University of Illinois at Chicago, the University of Pittsburgh, Vanderbilt University and InterMune from Brisbane, Calif.

Anna L. Peljto, DrPH, from the Colorado School of Public Health was the first author and David A. Schwartz, MD, chairman of the School of Medicine's Department of Medicine, was the senior author of the paper. Additional authors from Colorado institutions were Tasha E. Fingerlin, PhD, from the Colorado School of Public Health; Lori J. Silveira, PhD, Max A. Seibold, PhD, Kevin K. Brown, MD, and Janet L. Talbert, MS, from National Jewish Health; and Elissa Murphy, MS and Marvin I. Schwarz, MD, from the University of Colorado School of Medicine.

David Schwartz this month gave the American Thoracic Society's Amberson Lecture, an honor bestowed annually on an individual with a career of major lifetime contributions to clinical or basic pulmonary research and/or clinical practice. The JAMA study was released online to coincide with its presentation at the American Thoracic Society's international conference.


'/>"/>

Contact: Mark Couch
mark.couch@ucdenver.edu
303-724-5377
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. Leading researchers report on the elusive search for biomarkers in Huntingtons disease
2. Dissertation Clinic Prescribes Customized Remedy for Researchers
3. AGA honors distinguished clinicians, researchers and educators with prestigious recognition awards
4. Moffitt Cancer Center researchers analyze how Spanish smoking relapse booklets are distributed
5. Researchers say they are shocked by new statistics on head injuries among people who are homeless
6. A Premium Service for Researchers Launched in Switzerland
7. Two Leading Alzheimer's Disease Researchers Recognized with MetLife Foundation Awards
8. PolyU Researchers Develop Novel Brain Training Device to Reconnect the Brain and Paralyzed Limb After Stroke
9. University of Colorado Researchers Find Dual Chamber Defibrillators Pose Higher Risk of Complications
10. Leap in leukemia treatment reported by Dartmouth researchers
11. Researchers discover master regulator that drives majority of lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... (PRWEB) , ... February 24, 2017 , ... The ... for excellence in radiology marketing programs at the annual Building Better Radiology Marketing ... Renaissance Fort Worth Hotel in Fort Worth, Texas. Nine awards are given out in ...
(Date:2/24/2017)... ... February 24, 2017 , ... ... Senior International Elite division on February 12th. Ms. Esparza qualified into this ... elite qualifier competition held in Las Vegas, Nevada. Frida is one of approximately ...
(Date:2/23/2017)... ... February 23, 2017 , ... Thinksport, the most award-winning ... Gran Fondo of Marin. For the second year in a row, cyclists will ... , “We are thrilled to provide our safe, non-toxic sunscreen to over 2,000 ...
(Date:2/23/2017)... ... February 23, 2017 , ... The 89th Academy Awards will be ... 2016 National Education Policy Center Bunkum Award. We invite you to enjoy our 11th ... year’s Bunkum winner is the Center for American Progress (CAP), for its report, Lessons ...
(Date:2/23/2017)... ... February 23, 2017 , ... Rare Disease Report®, which ... participating in Rare Disease Day events, hosted by the Rare Disease Legislative Advocates ... a website, weekly e-newsletter and quarterly publication, will be conducting interviews with patients ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... , Feb. 23, 2017 Visiomed, the ... services since 1997, is changing the landscape of ... providing patients with pro-active, custom-made solutions. Recognizing the ... instant and affordable healthcare without walls, Visiomed has ... devices developed with healthcare professionals that is empowering ...
(Date:2/23/2017)... , Südkorea, 23. Februar 2017 LG Innotek ... Sterilisationsaufgaben vorgestellt. Die Sterilisationsleistung beträgt das 1,5-fache des 45-mW-Moduls ... Strahlung im Bereich zwischen 200 und 280 nm und eignet ... Bakterien, indem es ihre DNA zerstört. Das Produkt von ... ...
(Date:2/23/2017)... Feb. 23, 2017 Nevro Corp. (NYSE: NVRO), a ... for the treatment of chronic pain, today reported financial results ... 2016. 2016 Accomplishment & Highlights: ... 2016, an increase of 228% as reported, over the prior ... an increase of 612% over the prior year ...
Breaking Medicine Technology: