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Researchers find gene location that gives rise to neuroblastoma, an aggressive childhood cancer
Date:5/7/2008

initial changes on chromosome 6 in all their body cells eventually led to the genetic abnormalities seen in tumor cells in high-risk forms of the disease.

Because their finding reveals only the first step in a series of molecular events, added Maris, it would be premature to do prenatal genetic testing for the SNPs on chromosome 6. His research team will continue to perform genetic analyses, in search of other gene changes that interact with those SNPs. One data source will be 5,000 tissue samples in Mariss labthe worlds largest collection of neuroblastoma samples, drawing on decades of research into the disease by Maris, his colleagues and predecessors at Childrens Hospital.

This discovery lays the foundation for learning how these initial changes influence biological pathways that lead to neuroblastoma, added Maris. Understanding those pathways may guide us to new and better therapies that precisely target this cancer. Hakonarson added, This study represents one of many ongoing projects to which scientists at The Childrens Hospital of Philadelphia are committed, and we anticipate several comparable discoveries will be made in other common and equally complex pediatric disorders, such as autism, asthma, ADHD and diabetes.


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Contact: Rachel Salis-Silverman
Salis@email.chop.edu
267-426-6063
Children's Hospital of Philadelphia
Source:Eurekalert

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