Navigation Links
Researchers find gene location that gives rise to neuroblastoma, an aggressive childhood cancer
Date:5/7/2008

with neuroblastoma, added Maris.

However, little was known about genetic events that predispose a child to developing a neuroblastoma tumor. In roughly half of neuroblastoma cases, the cancer is not discovered until it has spread widely in a patients body, so understanding how a tumor originates may allow oncologists to design earlier and more successful interventions.

In the current study, Mariss team collaborated with Hakon Hakonarson, M.D., Ph.D., director of Childrens Hospitals Center for Applied Genomics, to analyze blood samples from approximately 1,000 neuroblastoma patients, as well as samples from some 2,000 healthy children recruited through the Childrens Hospital network. A DNA chip analysis performed at the genome center identified three single nucleotide polymorphisms (SNPs)changes in single bases on the DNA helix. Out of over 550,000 SNPs studied, those SNPs were much more common in patients with neuroblastoma, compared to the controls. The three SNPs occurred together on a band of chromosome 6 designated 6p22.

The researchers repeated the analysis in blood samples from additional groups of patients and control subjects from the U.S. and the U.K., and confirmed their finding that variants in the 6p22 region were implicated in neuroblastoma. There are two genes in the 6p22 region, but their functions are largely unknown.

We are doing further studies to understand how these relatively common genetic changes translate into increased risk of cancer, said Maris. Ultimately, they probably cause subtle changes in gene expression during early development, interacting with other genes yet to be discovered. This suggests that neuroblastoma has complex causes, in which a series of genetic changes may occur at different sites to combine into a perfect storm that results in this cancer.

The researchers found that patients with these at-risk SNPs on chromosome 6 were more likely to develop aggressive neuroblastoma. The
'/>"/>

Contact: Rachel Salis-Silverman
Salis@email.chop.edu
267-426-6063
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... According to a new market research report ... Crystal, Microblinds, Thermographic and Photochromics), by application (Architectural, ... geography - Global Forecast to 2014 - 2020", ... market was worth $1581.4 Million in 2013, and ... at an estimated CAGR of 20% from 2014 ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 The ... leading nonprofit authority on the use of health ... announced the full agenda for its annual fall ... IT Efficiency. WEDI-Con 2014 will take place at ... 20-23, 2014, attracting a diverse cross-section of payers, ...
(Date:8/20/2014)... Fresh from the cradle of a world-class running ... starting blocks. , Urbini, a new collection of versatile baby ... Avi jogger to its lineup. , The Avi has ... inspired by the latest racing styles and a set of ... jogger offers a swift, smooth ride on runs, power-walks and ...
(Date:8/20/2014)... Los Angeles, CA (PRWEB) August 20, 2014 ... clinic has found a cure for it. With extensive research ... Therapy provider named ‘MetroMD’ claims to have perfected the art ... give you a brand new younger look with their revolutionary ... the secrets of the 21st century fountain of youth, the ...
(Date:8/20/2014)... Doctors at the University of Hong Kong claim to ... mice by injecting them with a vaccine that changes their ... on its website. Click here to read the full ... Institute of Microbiology created a vaccine using a protein called ... the vaccine is designed to prevent mesothelioma cells from disabling ...
Breaking Medicine News(10 mins):Health News:Smart Glass Market by Technology Worth $5814 Million by 2020 – New Report by MarketsandMarkets 2Health News:Smart Glass Market by Technology Worth $5814 Million by 2020 – New Report by MarketsandMarkets 3Health News:Smart Glass Market by Technology Worth $5814 Million by 2020 – New Report by MarketsandMarkets 4Health News:Smart Glass Market by Technology Worth $5814 Million by 2020 – New Report by MarketsandMarkets 5Health News:WEDI Releases Full Conference Agenda for Its Annual Fall Conference – WEDI-Con 2014 2Health News:WEDI Releases Full Conference Agenda for Its Annual Fall Conference – WEDI-Con 2014 3Health News:Urbini Breezes Through Summer with New Jogging Stroller 2Health News:MetroMD Offers Revolutionary Anti-aging Hormone Therapy in Hollywood Area 2Health News:New Research Study Finds Vaccine Stops Mesothelioma in Lab Mice, According to Surviving Mesothelioma Website 2
... permission with European medicine regulators to begin selling its new ... in the US last month, and comes slightly earlier than ... be one of GSK's most promising pipeline drugs as well ... the sales of the drug could cross 2 bln used ...
... world who get uncomfortable after a heavy meal here is ... have proven that eating 6-8 walnuts (approx.40g) after a rich ... triggered of in the walls of arteries after a highly ... the Oct. 17 issue of the Journal of the American ...
... given to bowel cancer patients before the surgical removal ... risk of recurrence to 1 %. The usual ... of recurrence is there and once reappeared, treatment is ... conducted an international study, to compare the effect of ...
... after irrigation water samples tested positive for E. coli ... relaxed its advisory against eating fresh spinach. ... detected after a secondary water source temporarily used to ... the water got contaminated is still not clear. ...
... challenges parenting stereotypes; Today’s parents boast about the numerous classes ... and the many talents they possess. Competitive parents in their ... ‘super-kids’ , often smother their children with an over-dose of ... gizmos , play stations, and game boys… and Oh boy, ...
... Around 45 Iraqi children have arrived in Bahrain to receive ... to arrive in the coming days as part of an ... move Sunday came in response to a call to help ... composer Naseer Shamma, who is the head of the newly ...
Cached Medicine News:Health News:Walnuts May Help Fight Fat and Keep Arteries Supple 2
(Date:8/19/2014)... Ohio , Aug. 19, 2014 Minimally ... medical device company, announced today that Mitsubishi ... laparoscopic and robotic visualization system in Japan ... for sale in Japan in ... is also the exclusive distributor for Karl Storz GMBH ...
(Date:8/19/2014)... YORK , Aug. 19, 2014  As ... around the country, Bernstein Liebhard LLP notes that ... can choose between a number of options that ... dangerous surgical instrument. According to a report published ... th , these options include a mini-laparotomy and ...
(Date:8/19/2014)... Aug. 19, 2014 Research and Markets ... Type of Material, by Technology, by Application & by Region- ... offering. The demand for membranes is estimated ... the market to $29.31 billion Membrane technology was ... such as water filtration and kidney dialysis. In modern times, ...
Breaking Medicine Technology:Minimally Invasive Devices and Mitsubishi Medical Japan Forge Exclusive Distribution Agreement 2As Morcellator Lawsuits Mount, Bernstein Liebhard LLP Notes Report Detailing Alternatives to Uterine Morcellation 2As Morcellator Lawsuits Mount, Bernstein Liebhard LLP Notes Report Detailing Alternatives to Uterine Morcellation 3Global Membranes (MF, RO, UF, Gas Separation, Dialysis, NF) Market - Forecasts to 2019 2
... Oct. 19, 2009 Amylin Pharmaceuticals, Inc. (Nasdaq: ... obesity program will be presented at Obesity 2009, the ... be held in Washington, D.C. October 24-28. Phase 2 ... be the subject of a late-breaking oral presentation. Obesity ...
... , SILVER SPRING, Md., Oct. 19 The U.S. Food ... to be approved for kidney cancer since 2005. , (Logo: ... oral medication that interferes with angiogenesis, the growth of new ... , Votrient is intended for people with advanced renal ...
Cached Medicine Technology:Amylin Pharmaceuticals Highlights New Data Supporting Therapeutic Potential of Obesity Pipeline at Obesity 2009 2Amylin Pharmaceuticals Highlights New Data Supporting Therapeutic Potential of Obesity Pipeline at Obesity 2009 3Amylin Pharmaceuticals Highlights New Data Supporting Therapeutic Potential of Obesity Pipeline at Obesity 2009 4Amylin Pharmaceuticals Highlights New Data Supporting Therapeutic Potential of Obesity Pipeline at Obesity 2009 5FDA Approves New Treatment for Advanced Form of Kidney Cancer 2
... if it is not the Flu? Streptococcus ... bacterial "flu-like" infections. The easy-to-use, rapid, urine-based ... within the new 4 hour guidelines. Rapid ... improved patient outcomes and lower overall health ...
Single Use Loading Units with Titanium Staplers for use with MULTIFIRE ENDO TA™ 30 12 mm (Single Use Staplers with Titanium Staplers)....
Single Use Loading Units (SULU's) Knifeless for use with MULTIFIRE ENDO GIA™ 30 12 mm (Single Use Staplers with Titanium Staples)....
Single Use Loading Units (SULU's) with Titanium Staples for use with MULTIFIRE ENDO GIA™ 30 12 mm (Single Use Staplers with Titanium Staples)....
Medicine Products: