Navigation Links
Researchers find gene location that gives rise to neuroblastoma, an aggressive childhood cancer
Date:5/7/2008

with neuroblastoma, added Maris.

However, little was known about genetic events that predispose a child to developing a neuroblastoma tumor. In roughly half of neuroblastoma cases, the cancer is not discovered until it has spread widely in a patients body, so understanding how a tumor originates may allow oncologists to design earlier and more successful interventions.

In the current study, Mariss team collaborated with Hakon Hakonarson, M.D., Ph.D., director of Childrens Hospitals Center for Applied Genomics, to analyze blood samples from approximately 1,000 neuroblastoma patients, as well as samples from some 2,000 healthy children recruited through the Childrens Hospital network. A DNA chip analysis performed at the genome center identified three single nucleotide polymorphisms (SNPs)changes in single bases on the DNA helix. Out of over 550,000 SNPs studied, those SNPs were much more common in patients with neuroblastoma, compared to the controls. The three SNPs occurred together on a band of chromosome 6 designated 6p22.

The researchers repeated the analysis in blood samples from additional groups of patients and control subjects from the U.S. and the U.K., and confirmed their finding that variants in the 6p22 region were implicated in neuroblastoma. There are two genes in the 6p22 region, but their functions are largely unknown.

We are doing further studies to understand how these relatively common genetic changes translate into increased risk of cancer, said Maris. Ultimately, they probably cause subtle changes in gene expression during early development, interacting with other genes yet to be discovered. This suggests that neuroblastoma has complex causes, in which a series of genetic changes may occur at different sites to combine into a perfect storm that results in this cancer.

The researchers found that patients with these at-risk SNPs on chromosome 6 were more likely to develop aggressive neuroblastoma. The
'/>"/>

Contact: Rachel Salis-Silverman
Salis@email.chop.edu
267-426-6063
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... 27, 2015 According to Health ... born with Neonatal Abstinence Syndrome (NAS) are causing alarm ... the painful withdrawal process for a month of their ... crying, diarrhea, and vomiting. The condition is precipitated by ... alcohol addiction treatment (and employing medically assisted drug treatment) ...
(Date:3/27/2015)... SMI (Silicon Microstructures, Inc.), a global MEMS pressure ... MEMS based ultra-miniature pressure sensor designed especially for the ... 220um x 75um provides ample space for 1-French catheter ... industry leading in vivo drift performance of 2 ... pressure range from 0 to 1,100 mmHg absolute. ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 California’s ongoing ... blizzards in Boston and the United States Northeast, are ... Earth warming global atmosphere is creating changes in the ... historical climatologist and former NASA researcher, speaking on the ... result is not only a warmer and dryer global ...
(Date:3/27/2015)... contenders and their avid audience will be in the ... baritone Sherrill Milnes will be overseeing the grand finale ... in Evanston. The event is the culmination of a ... around the country. “This is a highly-anticipated yearly event ... the country,” said Margaret Gergen, executive director of The ...
(Date:3/27/2015)... Atlanta, Georgia (PRWEB) March 27, 2015 To ... and shade issues, Super-Sod spent a year filming this video ... lawn needs and the shady environment it's often expected to ... shade. , All plants need light to survive. Anytime a ... essentially being put on a diet. Many homeowners try to ...
Breaking Medicine News(10 mins):Health News:In Florida Only 10% of Pregnant Mothers Are Referred to Drug Rehab Despite Testing Positive for Narcotics 2Health News:SMI Launches Catheter Mountable Pressure Sensor 2Health News:California Drought, Boston Blizzards Both Attributed to Global Climate Change Reports Climatologist to Fresh Water Advocate 2Health News:California Drought, Boston Blizzards Both Attributed to Global Climate Change Reports Climatologist to Fresh Water Advocate 3Health News:Opera Idol Competition At The Merion In Evanston 2Health News:For Spring Turf Planting Season, Super-Sod Created a New How-To Video Entitled "Two Views on Shade and Turf" 2
... yourself from the dangers of frostbiteROSEMONT, Ill., Jan. 13 /PRNewswire-USNewswire/ ... country this week, but cold weather is no excuse to ... go outside for some fresh air and exercise , ... body tissues are frostbitten, skin cells become damaged -- sometimes ...
... the Divided We Fail pledgeNEW YORK, Jan. 13 Today ... to thousands of AARP members pledging to work with President ... health care crisis and economic downturn. Senator Schumer spoke ... this afternoon from his office in Washington, DC. "Since ...
... Says Investment in Medicaid Should be Key Health Policy ... Speaker of the Texas House in Austin and a ... has created new and exciting opportunities in regard to ... of the state,s oldest, most vulnerable seniors, the Texas ...
... 13 Courage Center,s Ski and Snowboard,Program (CCSS) seeks volunteers ... Minn. , Volunteers assist skiers with ... 25-March 8, from 1 to 4 p.m. (no session,over President,s ... Volunteer instructors are also being recruited and ...
... pharmacy error in child,s medication; young man is hospitalized ... on labels causes grandmother to confuse medicationsWASHINGTON, Jan. 13 ... a dose of medication if you were not fully ... you do if you couldn,t read important drug information ...
... health issues, comply with federal and state health ... to help Philadelphia students eat healthier, get more ... conscious, the school district of Philadelphia announced it ... web-based program. The program is being provided to ...
Cached Medicine News:Health News:Is Jack Frost Nipping At Your Nose? 2Health News:Is Jack Frost Nipping At Your Nose? 3Health News:Senator Schumer Speaks to 4,900 AARP Members Pledging Bipartisan Action on Nation's Health and Economic Crises 2Health News:Senator Schumer Speaks to 4,900 AARP Members Pledging Bipartisan Action on Nation's Health and Economic Crises 3Health News:THCA: Protecting Seniors, Respecting Taxpayers the Right Agenda for Texas 2Health News:THCA: Protecting Seniors, Respecting Taxpayers the Right Agenda for Texas 3Health News:AFB Survey Finds Drug Labeling Puts People with Vision Loss at Serious Medical Risk 2Health News:AFB Survey Finds Drug Labeling Puts People with Vision Loss at Serious Medical Risk 3Health News:AFB Survey Finds Drug Labeling Puts People with Vision Loss at Serious Medical Risk 4Health News:Philadelphia School District and Independence Blue Cross Partner to Improve Student Wellness and Reduce Childhood Obesity 2Health News:Philadelphia School District and Independence Blue Cross Partner to Improve Student Wellness and Reduce Childhood Obesity 3Health News:Philadelphia School District and Independence Blue Cross Partner to Improve Student Wellness and Reduce Childhood Obesity 4Health News:Philadelphia School District and Independence Blue Cross Partner to Improve Student Wellness and Reduce Childhood Obesity 5
(Date:3/27/2015)... March 27, 2015 BioCorRx, Inc. ( ... Ana, California is a healthcare solutions organization, which ... estimated at $22 billion in the U.S. alone. The Company ... FDA-approved Naltrexone in a specially compounded form for outpatient surgical ... and New Zealand ) to ...
(Date:3/27/2015)... 2015 Across the global healthcare landscape, the ... clinical development, market education, and regulatory compliance. As emerging ... function is expected to increase in prominence and follow ... According to research by benchmarking firm, Best Practices, LLC, ... to Medical Affairs. Among companies in India ...
(Date:3/27/2015)...  The quality function within the medical device sector ... standards at every stage of the product life cycle. ... have the challenge of balancing quality and safety with ... effectively balance these priorities risk funding and staffing for ... regulatory scrutiny. For the third consecutive year, ...
Breaking Medicine Technology:Small Cap IR Correction -- BioCorRx Inc. Positions Itself Through Strategic Partnerships To Gain Market Share Of The $22 Billion Substance Abuse Treatment Market In The U.S. 2Medical Affairs Capabilities Expanding in Emerging Marketplaces 2New Medical Device Quality Study Finds Regulatory Environment is Boosting Quality Spending, Especially for Large Companies 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: