Navigation Links
Researchers find function of proteins that can enhance the progression of viruses and cancer cells
Date:8/16/2010

In a discovery that has implications for developing treatments against cancer and potentially deadly viruses, researchers at SUNY Downstate Medical Center have discovered the function of proteins that can enhance the progression of certain viruses and cancer cells. Their findings were published in the journal Genes and Development.

According to Tatyana Pestova, PhD, DSc, assistant professor of cell biology, and Christopher Hellen, DPhil, associate professor of cell biology, "The significance of our work is that we have identified proteins (Ligatin, MCT-1 and DENR) that can substitute for the activity of one or more canonical initiation factors in the initiation and ribosome recycling stages of eukaryotic protein synthesis. These factors act either individually (Ligatin) or together (MCT-1 and DENR) to substitute for eIF2 in promoting initiation of translation on a specific subset of mRNAs under conditions when translation is globally repressed. These observations are clinically relevant with respect to (a) viral infections and (b) cancer pathogenesis." Maxim Skabkin, PhD, a research scientist in the Department of Cell Biology, is the lead author of the paper.

The cellular response to counteract viral infection involves activation of pathways that "shut off" translation by phosphorylating eIF2, preventing it from recruiting initiator tRNA to the ribosome. Some viral mRNAs continue to be translated at the same or a reduced rate under these conditions, including those of Hepatitis C virus, human rotaviruses (a major cause of acute, frequently fatal, gastroenteritis in infants), coronaviruses (including SARS), and alphaviruses (e.g. Sindbis virus).

The authors reported a novel eIF2-independent mode of translation initiation in which Ligatin alone or MCT-1 and DENR together promote binding of initiator tRNA to specific ribosomal initiation complexes, and found that this mechanism functions very efficiently for Sindbis virus and to
'/>"/>

Contact: Ron Najman
ron.najman@downstate.edu
718-270-2696
SUNY Downstate Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. In NIH-funded study, researchers uncover step in brain events leading up to addiction
2. Researchers develop magnetic molecular machines to deliver drugs to unhealthy cells
3. UCLA researchers discover protein that shuttles RNA into cell mitochondria
4. Help wanted: Highly cited researchers needed for high-ranking positions at research institutions
5. NIST researchers measure high infrared power levels from some green lasers
6. Mayo Clinic researchers share latest findings in CT radiation dose reduction efforts
7. Researchers develop advanced search tool to help physicians sort and retrieve vital EMR data
8. Researchers identify key enzyme in DNA repair pathway
9. Researchers study benefits of white button mushrooms
10. Use of decision-aid program increases safety for women experiencing abuse, researchers find
11. Researchers uncover biological rationale for why intensive lupus treatment works
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... The Jones Firm, a law firm based ... injury and wrongful death, have years of experience handling ... ballast tractors, cement mixer trucks, mobile crane trucks, dump ... trucks. , With so many heavy trucks on ... 2,500 heavy truck accidents per year. , “ ...
(Date:7/11/2014)... July 11, 2014 Woodland Hills permanent ... of the Anacapa Dental Art Institute in Woodland Hills and ... World Symposium in Marina Del Rey, Calif. , The ... class on the permanent teeth in one day dental procedure ... in one day was developed 15 years ago, Dr. Jivraj ...
(Date:7/11/2014)... July 11, 2014 Avery Ranch announced ... and to show more about their services online. Customers ... and view their home videos online, their featured properties, ... is Austin, Texas’ premiere golf course community with 4000+ ... of Austin. Avery Ranch features an award winning 18 ...
(Date:7/11/2014)... Beverly Hills, CA (PRWEB) July 11, 2014 ... globe. However, according to recent reports , many star ... take a backseat in the media to American football when ... all sports, the risk is always there. While none of ... debilitating injuries, the possibility remains. Beverly Hills spine surgeon Dr. ...
(Date:7/11/2014)... 2014 This is a professional ... the Cholesterol industry in Global and China. The ... including definitions, applications and industry chain structure. Global ... provided with a focus on history, developments, trends ... between the international and Chinese situation is also ...
Breaking Medicine News(10 mins):Health News:Trucking Accident Injuries And Death Scrutinized By The Jones Firm In Recent Article 2Health News:Woodland Hills Dental Expert Speaking at Nobel Biocare World Symposium in One Week 2Health News:Woodland Hills Dental Expert Speaking at Nobel Biocare World Symposium in One Week 3Health News:Woodland Hills Dental Expert Speaking at Nobel Biocare World Symposium in One Week 4Health News:Woodland Hills Dental Expert Speaking at Nobel Biocare World Symposium in One Week 5Health News:Avery Ranch Announces Their New Website to Better Connect with Customers 2Health News:As World Cup Comes to an End, Injuries are Star of the Show 2Health News:As World Cup Comes to an End, Injuries are Star of the Show 3Health News:Cholesterol Industry 2014 Development Trends in Global & China Regions in a New Research Study Available at DeepResearchReports.com 2Health News:Cholesterol Industry 2014 Development Trends in Global & China Regions in a New Research Study Available at DeepResearchReports.com 3
... also plays a role in how infants learn to ... , University of Washington psychologists have learned that 10-month-old ... actions by a person to unravel novel actions. ... which the new action is performed. , "Infants, understanding ...
... Primary brain tumors affect nearly 20,000 Americans each yearand ... For young adults ages 30-39, brain tumors are ... fifth-leading among women. Despite significant advances in cancer ... malignant brain tumor, survive roughly 12 to 14 months ...
... the Bulge ... but Still Indulge!Food Experts HARRY EASTWOOD, ... Half-Hour Series from Tiger Aspect Productions Visitors to Mylifetime.com ... Hosts, Recipes Featured on the Show and Behind-the-Scenes FootageLOS ... your cake and eat it, too? Lifetime Television ...
... Craig Program Makes Client,s Dreams Come TrueCARLSBAD, Calif., Jan. ... success on the program, Jenny Craig Inc.,s newest spokeswoman, ... program called ,The Jenny Craig Great Take-Off,. The year-long ... their goals and dreams achievable through weight loss and ...
... Hospital has been honored with a 10th year on the FORTUNE ... on the 2009 list released today. Griffin is the only hospital ... first invited to apply for selection to the FORTUNE list in ... issued the list of "100 Best Companies to Work For" since ...
... and Space Museum show Brain - toys available for testing, ... Fat Brain Toy Co. announced today that they will be ... World Inside Your Head, on opening day January 24, 2009. ... museum is located at 28210 West Park Highway in Ashland, ...
Cached Medicine News:Health News:Infants draw on past to interpret present, understand other people's behavior 2Health News:Infants draw on past to interpret present, understand other people's behavior 3Health News:New institute targets brain tumor removal 2Health News:Cook Yourself Thin With Lifetime Television as All-New Culinary Series Teaches Viewers How to Make Their Favorite Foods Healthy 2Health News:Cook Yourself Thin With Lifetime Television as All-New Culinary Series Teaches Viewers How to Make Their Favorite Foods Healthy 3Health News:Jenny Craig Inc. Announces New Wellness Campaign: 'The Great Take-Off' 2Health News:Griffin Honored with Tenth Year on FORTUNE Best Companies to Work for List 2
(Date:1/15/2014)... 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting ... China,s orthopedic instrument industry has ... size rising from 3.28 billion yuan in 2006 to ...
(Date:1/15/2014)... Mich. , Jan. 15, 2014 As health officials ... flu virus, select Meijer pharmacies in Michigan ... throat to eligible patients, enabling Meijer pharmacists to administer tests ... protocol set by a physician participating in the study. ...
(Date:1/15/2014)... , Jan. 15, 2014  Celsion Corporation (the "Company") (NASDAQ: ... received commitments from institutional investors to purchase an aggregate ... in an at-the-market registered direct offering, led by a ... into definitive purchase agreements with these investors pursuant to ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3
... Nov. 22, 2011  Questcor Pharmaceuticals, Inc. (NASDAQ:   QCOR) ... Piper Jaffray Healthcare Conference to be held on November ... and Chief Executive Officer, is scheduled to present an ... and Q&A session on Wednesday, November 30, 2011 at ...
... is in crisis throughout the world, but an ... biotech and pharmaceutical CEOs and other senior executives ... forum, "Eliminating the Gap between Innovation and Resources," ... San Francisco,s historic Marines, Memorial Club, hosted by ...
Cached Medicine Technology:Questcor Pharmaceuticals to Present at the Piper Jaffray Healthcare Conference on November 30, 2011 2'The Global Leaders' Seek Solutions to Healthcare Crisis by Bringing Together Investors With CEOs in Healthcare, Biotech and Pharma 2
... designed with a spring-loaded mechanism to ensure ... gel cassettes stay firmly in place during ... loading from one gel to the next ... robot loading software. In addition, the E-Holder™ ...
... electrophoresis into an automated, high-throughput operation with ... system is ideal for analyzing multiple PCR ... Fully automated, robot-compatible, and ready to put ... your high-throughput screening assignments as easy as ...
... are seamless eliminating the possibility of leakage around ... have temperature resistant gel trays meaning you do ... For added user friendliness, the Primo tanks come ... The Primo Gel Systems are designed to ...
... Submarine gels may be formed directly on ... to contain the agarose as it cools, or ... sealed with tape. Gel is 7.5cm wide 10cm ... your lab requires (e.g., RNA only). Combs and ...
Medicine Products: