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Researchers find first conclusive evidence of Alzheimer's-like brain tangles in nonhuman primates
Date:5/14/2008

and identify targets for therapeutics."

The research reported in the Journal of Comparative Neurology is just one of the projects at Yerkes aimed at uncovering underlying mechanisms and pathogenesis of Alzheimer's disease. Walker is evaluating the immune response of squirrel monkeys to a vaccine targeting beta-amyloid protein. The goal is to see if the vaccine prompts the immune system to make antibodies against the protein without side effects. In another study, Rosen is looking at the structure of beta-amyloid protein in multiple primate species with the hope of identifying the correct target for new drugs and immunotherapy.

Rosen noted Yerkes has provided her with unparalleled access to resources for graduate-level research and training. Added Walker, "Yerkes is one of the only facilities in the world that offers researchers the resources to study chimpanzees across the entire lifespan, including behavior, biochemistry, physiology, molecular biology and disease pathology."

For more than seven decades, the Yerkes National Primate Research Center, Emory University, has been dedicated to conducting essential basic science and translational research to advance scientific understanding and to improve the health and well-being of humans and nonhuman primates. Today, the center, as one of only eight National Institutes of Healthfunded national primate research centers, provides leadership, training and resources to foster scientific creativity, collaboration and discoveries. Yerkes-based research is grounded in scientific integrity, expert knowledge, respect for colleagues, an open exchange of ideas and compassionate, quality animal care.

Within the fields of microbiology and immunology, neuroscience, psychobiology and sensory-motor systems, the center's research programs are seeking ways to: develop vaccines for infectious and noninfectious diseases, such as AIDS and Alzheimer's disease; treat cocaine addiction; interpret brain acti
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Contact: Emily Rios
erios@emory.edu
404-727-7732
Emory University
Source:Eurekalert

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