Navigation Links
Researchers find evidence that brain compensates after traumatic injury
Date:11/25/2012

November 26, 2012 (BRONX, NY) Researchers at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center have found that a special magnetic resonance imaging (MRI) technique may be able to predict which patients who have experienced concussions will improve. The results, which were presented today at the annual meeting of the Radiological Society of North America (RSNA), suggest that, in some patients, the brain may change to compensate for the damage caused by the injury.

"This finding could lead to strategies for preventing and repairing the damage that accompanies traumatic brain injury," said Michael Lipton, M.D., Ph.D., who led the study and is associate director of the Gruss Magnetic Resonance Research Center at Einstein and medical director of MRI services at Montefiore, the University Hospital and academic medical center for Einstein.

Each year, 1.7 million people in the U.S., sustain traumatic brain injuries (TBI), according to the Centers for Disease Control and Prevention. Concussions and other mild TBIs (or mTBIs) account for at least 75 percent of these injuries. Following a concussion, some patients experience a brief loss of consciousness. Other symptoms include headache, dizziness, memory loss, attention deficit, depression and anxiety. Some of these conditions may persist for months or even years in as many as 30 percent of patients.

The Einstein study involved 17 patients brought to the emergency department at Montefiore and Jacobi Medical Centers and diagnosed with mTBI. Within two weeks of their injuries, the patients underwent diffusion tensor imaging (DTI), which "sees" the movement of water molecules within and along axons, the nerve fibers that constitute the brain's white matter. DTI allows researchers to measure the uniformity of water movement (called fractional anisotropy or FA) throughout the brain. Areas of low FA indicate axonal injury while areas of abnormally high FA indicate changes in the brain.

"In a traumatic brain injury, it's not one specific area that is affected but multiple areas of the brain which are interconnected by axons," said Dr. Lipton, who is also associate professor of radiology, of psychiatry and behavioral sciences, and in the Dominick P. Purpura Department of Neuroscience at Einstein. "Abnormally low FA within white matter has been correlated with cognitive impairment in concussion patients. We believe that high FA is evidence not of axonal injury, but of brain changes that are occurring in response to the trauma."

One year after their brain injury, the patients completed two standard questionnaires to assess their post-concussion symptoms and evaluate their health status and quality of life. "Most TBI studies assess cognitive function, but it is not at all clear if and how well such measures assess real-life functioning," said Dr. Lipton. "Our questionnaires asked about post-concussion symptoms and how those symptoms affected patients' health and quality of life."

Comparing the DTI data to the patient questionnaires, the researchers found that the presence of abnormally high FA predicted fewer post-concussion symptoms and better functioning. The results suggest that the brain may be actively compensating for its injuries in patients who exhibit areas of high FA on DTI.

"These results could lead to better treatment for concussion if we can find ways to enhance the brain's compensatory mechanisms." Dr. Lipton said.

Dr. Lipton's Einstein and Montefiore coauthors are Sara B. Rosenbaum, B.A., Namhee Kim, Ph.D., Ph.D., Craig A. Branch, Ph.D., Richard B. Lipton, M.D., and Molly E. Zimmerman, Ph.D.


'/>"/>

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Related medicine news :

1. Researchers find decline in availability and use of key treatment for depression
2. Researchers implicate well-known protein in fibrosis
3. Researchers build synthetic membrane channels out of DNA
4. JTCC researchers play important role in groundbreaking study that may change transplant practices
5. Researchers use computer simulations to find true cost of HIV screenings
6. Sleeping Pill Linked to Hospital Falls, Researchers Say
7. Daycare has many benefits for children, but researchers find mysterious link with overweight
8. Researchers outline effective strategies to prevent teen depression and suicide
9. Researchers report potential new treatment to stop Alzheimers disease
10. Feinstein Institute researchers discover plant derivative
11. Sociology, economics researchers receive grant to study development across the human lifespan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of ... Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, ... In honor of Morris F. Collen, a pioneer in the field of medical informatics, ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... Hair Restoration, has recently contributed a medical article to the newly revamped ... Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... On Saturday, ... a treadmill relay – Miles by Moonlight to raise money for the American Heart ... or more. , Teams will work together to keep their treadmills moving for ...
(Date:10/12/2017)... ... October 12, 2017 , ... In the United States, ... In some states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the ... have extremely low property-tax rates, which contributes to the relatively lower cost of ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... enhanced Pepper Flow promotional review platform at the Promotional Review Committee Compliance ... capabilities help marketers streamline the medical, legal, and regulatory review (MLR) process ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... -- West Pharmaceutical Services, Inc. (NYSE: WST), ... administration, today announced that it will release third-quarter 2017 ... 26, 2017, and will follow with a conference call ... a.m. Eastern Time. To participate on the call, please ... is 94093362. A ...
(Date:10/11/2017)... 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today ... Las Piedras, Puerto Rico , where ... Following a comprehensive ... minor structural damage, temporary loss of power and minimal ... completed, manufacturing operations have resumed, and the company expects ...
(Date:10/5/2017)... ROSEMONT, Ill. , Oct. 5, 2017 /PRNewswire-USNewswire/ ... American Association of Oral and Maxillofacial Surgeons (AAOMS) ... than opioids – to be used as a ... post-surgical pain. ... relationship, the AAOMS White Paper "Opioid Prescribing: Acute ...
Breaking Medicine Technology: