Navigation Links
Researchers find evidence that brain compensates after traumatic injury
Date:11/25/2012

November 26, 2012 (BRONX, NY) Researchers at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center have found that a special magnetic resonance imaging (MRI) technique may be able to predict which patients who have experienced concussions will improve. The results, which were presented today at the annual meeting of the Radiological Society of North America (RSNA), suggest that, in some patients, the brain may change to compensate for the damage caused by the injury.

"This finding could lead to strategies for preventing and repairing the damage that accompanies traumatic brain injury," said Michael Lipton, M.D., Ph.D., who led the study and is associate director of the Gruss Magnetic Resonance Research Center at Einstein and medical director of MRI services at Montefiore, the University Hospital and academic medical center for Einstein.

Each year, 1.7 million people in the U.S., sustain traumatic brain injuries (TBI), according to the Centers for Disease Control and Prevention. Concussions and other mild TBIs (or mTBIs) account for at least 75 percent of these injuries. Following a concussion, some patients experience a brief loss of consciousness. Other symptoms include headache, dizziness, memory loss, attention deficit, depression and anxiety. Some of these conditions may persist for months or even years in as many as 30 percent of patients.

The Einstein study involved 17 patients brought to the emergency department at Montefiore and Jacobi Medical Centers and diagnosed with mTBI. Within two weeks of their injuries, the patients underwent diffusion tensor imaging (DTI), which "sees" the movement of water molecules within and along axons, the nerve fibers that constitute the brain's white matter. DTI allows researchers to measure the uniformity of water movement (called fractional anisotropy or FA) throughout the brain. Areas of low FA indicate axonal injury while areas of abnormally high FA indicate changes in the brain.

"In a traumatic brain injury, it's not one specific area that is affected but multiple areas of the brain which are interconnected by axons," said Dr. Lipton, who is also associate professor of radiology, of psychiatry and behavioral sciences, and in the Dominick P. Purpura Department of Neuroscience at Einstein. "Abnormally low FA within white matter has been correlated with cognitive impairment in concussion patients. We believe that high FA is evidence not of axonal injury, but of brain changes that are occurring in response to the trauma."

One year after their brain injury, the patients completed two standard questionnaires to assess their post-concussion symptoms and evaluate their health status and quality of life. "Most TBI studies assess cognitive function, but it is not at all clear if and how well such measures assess real-life functioning," said Dr. Lipton. "Our questionnaires asked about post-concussion symptoms and how those symptoms affected patients' health and quality of life."

Comparing the DTI data to the patient questionnaires, the researchers found that the presence of abnormally high FA predicted fewer post-concussion symptoms and better functioning. The results suggest that the brain may be actively compensating for its injuries in patients who exhibit areas of high FA on DTI.

"These results could lead to better treatment for concussion if we can find ways to enhance the brain's compensatory mechanisms." Dr. Lipton said.

Dr. Lipton's Einstein and Montefiore coauthors are Sara B. Rosenbaum, B.A., Namhee Kim, Ph.D., Ph.D., Craig A. Branch, Ph.D., Richard B. Lipton, M.D., and Molly E. Zimmerman, Ph.D.


'/>"/>

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Related medicine news :

1. Researchers find decline in availability and use of key treatment for depression
2. Researchers implicate well-known protein in fibrosis
3. Researchers build synthetic membrane channels out of DNA
4. JTCC researchers play important role in groundbreaking study that may change transplant practices
5. Researchers use computer simulations to find true cost of HIV screenings
6. Sleeping Pill Linked to Hospital Falls, Researchers Say
7. Daycare has many benefits for children, but researchers find mysterious link with overweight
8. Researchers outline effective strategies to prevent teen depression and suicide
9. Researchers report potential new treatment to stop Alzheimers disease
10. Feinstein Institute researchers discover plant derivative
11. Sociology, economics researchers receive grant to study development across the human lifespan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... February 11, 2016 , ... From March ... Academy of Dermatology Annual Meeting at the Walter E. Washington Convention Center in ... for both the condition of hyperhidrosis (excessive sweating) and its treatment options. Specifically, ...
(Date:2/11/2016)... ... February 11, 2016 , ... Husted Kicking has completed its Third ... February 6th & 7th, 2016 according to kicking coach Michael Husted. , “This event ... the NFL’s combine in Indianapolis,” says Husted. “The NFL uses a third party organization ...
(Date:2/11/2016)... ... February 11, 2016 , ... The book, “Computers Should ... services, what questions to ask your IT consultant before signing a contract and how ... computer network. , “With companies relying heavily on e-mail and technology, it’s more important ...
(Date:2/11/2016)... ... February 11, 2016 , ... As part of their 2015 end of ... Round Table Foundation (MDRTF), has gifted $10,000 to University of Chicago to support ovarian ... Billy Cundiff. , “We are honored to support a promising young investigator from Dr. ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... as the World Molecular Imaging Congress (WMIC), will be held in New York ... meeting is “Imaging Biology…Improving Therapy.” The congress will highlight and emphasize how imaging ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... F ast access to ... at the point of need   ... and services, has launched a ClinicalKey mobile app that enables ... Elsevier designed the mobile app to allow users to select access to ... Android and iOS formats for mobile phone and tablet. ...
(Date:2/11/2016)... , Feb. 11, 2016 Scientists ... cell-isolation method that opens the door to genetic ... now have been impossible to isolate with 100 ... isolate specific tumor types in various stages of ... variants of these cells that are clinically relevant, ...
(Date:2/11/2016)... , Feb. 11, 2016  NanoViricides, Inc. ... it has entered into an agreement with the ... nanoviricides® drug candidates in standard animal models of ... , Research Director. Dr. Romanowski has extensive experience ... --> Eric Romanowski , Research ...
Breaking Medicine Technology: