Navigation Links
Researchers find drug that inhibits acute leukemia cell growth
Date:4/24/2009

SAN DIEGO - Researchers from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center have discovered how to turn off a certain receptor that promotes the growth of leukemia cells. The pre-clinical study was presented today in a platform session at the 22nd annual meeting of the American Society of Pediatric Hematology/Oncology (ASPHO).

"There is a certain receptor we now know is expressed in acute myeloid leukemia (AML) cells called Tropomyosin Receptor Kinase A (TRKA)," said Mauricio Ghisoli, M.D., fellow at the Children's Cancer Hospital at M. D. Anderson. "When TRKA gets turned on by a nerve growth factor (NGF) ligand, the AML cells start to rapidly grow."

Ghisoli and researchers at M. D. Anderson have found that using a TRK inhibitor, AZ23, turns off NGF, which led to a 50 percent reduction of AML cells in mice with no immune system. When studied in mice with an immune system present, researchers found that 60 percent of the mice treated with AZ23 had long-term survival with no presence of leukemia cells.

They also found AZ23 to be more effective in human AML cell lines that expressed higher levels of TRKA. This pre-clinical discovery could potentially allow clinicians to decipher which patients may have the best response to the drug in the future, explained Ghisoli.

Acute leukemia is the most common cancer in children, according to the American Cancer Society. Acute lymphoblastic leukemia, the more common type, has a cure rate of 80 percent, but children with the rarer type, AML, have only a 50 percent chance of a cure in comparison.

"Young patients with acute lymphocytic leukemia have a great chance of being cured using the standard treatments available out there today," said Patrick Zweidler-McKay, M.D., Ph.D., assistant professor at the Children's Cancer Hospital and senior investigator. "However, we have to find alternatives to increase the chance of cure for pediatric patients diagnosed with AML. Understanding how to turn off switches that promote cancer cell production is one way to do this."

In pre-clinical tests on solid tumor cell lines, AZ23 was found effective against the tumors. A Phase I clinical trial is planned to open this year for adults with solid tumor cancers.


'/>"/>

Contact: Lindsay Anderson
lindsay.anderson@gabbe.com
212-220-4444
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Related medicine news :

1. Researchers find medical inpatients with unhealthy alcohol use may benefit from brief intervention
2. Karmanos Cancer Institute Researchers Provide New Hope for Breast Cancer Treatment
3. The Traveling Nut: Researchers From Around the World Explore the Impact of Almonds on the Body
4. Brigham and Women's Hospital Researchers Demonstrate a More Direct Delivery of Cancer Drugs to Tumors
5. Mayo Clinic-led researchers confirm gene variants associated with the most common adult leukemia
6. Mayo Clinic researchers formulate treatment combination lethal to pancreatic cancer cells
7. USC researchers develop new drug to target tumor cells and blood vessels
8. Pitt receives $2.8 million to train HIV/AIDS researchers in Mozambique, Brazil and India
9. Pelvic pain as prevalent in teens as older males, Queens researchers discover
10. Yerkes researchers use eye tracking to detect mild dementia in humans
11. Stanford researchers harness nanoparticles to track cancer-cell changes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... May 03, 2016 , ... Hydra Skin Sciences, a top-rated skincare company ... a revolutionary new anti-aging skin care product that integrates Snow Algae Powder ... sold over seventy-five thousand units worldwide within the first two months of release. , ...
(Date:5/3/2016)... ... , ... Dave Newberry, broker/owner of Newberry Realty, recently announced his office will ... on Friday, May 20. “We have raised over $1,000 for the table to support ... , PICC is a local Kent, WA, clinic that cares for drug-exposed babies and ...
(Date:5/2/2016)... ... 2016 , ... RNK Products, Inc. (RNK) is beta testing ... the stethoscope stream to go over the video conferencing audio channel. This ... , Remote auscultation involves two software elements on the PC: , 1)    Network transport ...
(Date:5/2/2016)... ... , ... ProElectric Cartoon is a package of 30 hand-drawn electrifying animations made ... of electric styles including zap, sizzles, and more. Easily alter the highlights, midtones, and ... rotation, and much more. ProElectric Cartoon’s simplistic style makes it the perfect complement for ...
(Date:5/2/2016)... Texas (PRWEB) , ... May 02, 2016 , ... Pets ... As a token of appreciation, pet owners celebrate National Pet Week, which falls on ... in 2016, remind pet owners to cherish the human-animal bond and recognize responsible pet ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016 ... consumer insights on healthcare, announced today that it has ... report Cool Vendor in Life Sciences, 2016, ... 15, 2016.  The report focuses on life-science- oriented analytics, ... insight from patients and doctors, confirm medication ingestion, and ...
(Date:4/28/2016)... 2016 Dr. Vivek Ahuja , ... Ste phen Schmidt ... provider of cloud-based software solutions for life sciences, today announced key ... a wealth of insight to a growing business.  This will bolster ... George Phillips joined ArisGlobal in the position of Vice ...
(Date:4/28/2016)... N.J. , April 28, 2016   Acsis ... today announced that leading IT market research and advisory ... " in the IDC MarketScape: Worldwide Pharmaceutical Track and ... 2016).  The report provides an assessment of the capabilities ... track and trace software market. Logo - ...
Breaking Medicine Technology: