Navigation Links
Researchers find compound effective in destroying antibiotic-resistant biofilms
Date:4/8/2010

Researchers at North Carolina State University have found a chemical compound that, when used in conjunction with conventional antibiotics, is effective in destroying biofilms produced by antibiotic-resistant strains of bacteria such as the Staphylococcus strain MRSA and Acinetobacter. The compound also re-sentsitizes those bacteria to antibiotics.

Infections from antibiotic-resistant bacteria such as MRSA are especially difficult to get rid of because the bacteria can attach to surfaces and then create biofilms, sticky layers of cells that act as a shield and prevent antibiotics from destroying the bacteria underneath. While a limited number of existing antibiotics may destroy part of the biofilm, enough bacteria survive to create a recurring infection as soon as antibiotic therapy stops, and over time the surviving bacteria build resistance to that antibiotic.

NC State chemist Dr. Christian Melander had already shown that combining a compound made from a class of molecules known as 2-aminoimidazoles with antibiotics was effective in dispersing the biofilms created by certain bacterial strains. The next step was to see if this combination could remove resistant bacteria from surfaces.

"The problem with biofilms is that even if you treat with effective antibiotics, they never succeed in completely dispersing the biofilm and killing the bacteria on the surface they've stuck to," Melander says. "This is especially exacerbated when the bacteria are antibiotic resistant. Basically, if you are trying to treat a multi-drug resistant bacterial infection, you need to worry about both the bacteria forming a biofilm and disarming their antibiotic resistance genes."

Melander and his team, in collaboration with NC State biochemist John Cavanagh, found that pre-treating the bacteria with their compound and then introducing the antibiotic penicillin one hour later increased the penicillin's effectiveness 128-fold, even when the bacteria was penicillin resistant. The antibiotics also provided a 1,000-fold enhancement to the ability of the 2-aminoimidazole to disperse biofilms.

The researchers' results were published online March 8 in the journal Antimicrobial Agents and Chemotherapy.

"We had two goals in mind to overcome antibiotic resistance and to disperse biofilms," Melander says. "This compound cooperates with conventional antibiotics, overcoming an infectious threat that would otherwise persist if treated with either agent individually."


'/>"/>

Contact: Tracey Peake
tracey_peake@ncsu.edu
919-515-6142
North Carolina State University
Source:Eurekalert

Related medicine news :

1. UCSF Researchers Identify Regulator of Human Sperm Cells
2. Researchers find broad spectrum antiviral that fights multitude of viruses
3. University of Alberta researchers develop drug interface to save lives
4. Caregivers of ICU patients are collateral damage of critical illness, say Pitt researchers
5. Researchers fight world hunger by mapping the soybean genome
6. HIV researchers solve key puzzle after 20 years of trying
7. UC Davis researchers identify brain protein for synapse development
8. UCLA cancer researchers perform complete genomic sequencing of brain cancer cell line
9. Researchers find new way to study how enzymes repair DNA damage
10. UCLA researchers image earliest signs of Alzheimers, before symptoms appear
11. Researchers find leukemia cells metabolize fat to avoid cell death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... ... David J. Dykeman , Ginger Pigott , and J. Rick ... West, Dec. 12, 2016, at the Fairmont Newport Beach in California. Greenberg Traurig is ... Sciences & Medical Technology Group have been featured speakers at every DeviceTalks conference since ...
(Date:12/8/2016)... ... December 08, 2016 , ... SunView Software aims to redefine ... are both engaging and easy to use. Coming off the heels of a ... today its plans to roll out new AI-powered self-service enhancements to help organizations ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... solutions for drugs, biologics and consumer health products, today announced that it had ... in 2006 as a non-profit organization to unite pharmaceutical and healthcare companies that ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... STAT courier ... to be a convenient service for Texas, they are expanding their presence in Dallas. ... a hiring spree that will bring new jobs to the Dallas and Forth Worth ...
(Date:12/8/2016)... ... December 08, 2016 , ... Today’s ... possible. With this in mind, SIGVARIS has created a new line of anti-embolism ... bed rest and provide the benefits of graduated compression when transitioning from recovery ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... -- Research and Markets has announced the addition ... report to their offering. ... Market growth can be attributed ... pharmaceutical and biotechnology industry and technological advancements like automation and ... and growing research activities in toxicology and stem cells provide ...
(Date:12/9/2016)... Research and Markets has announced the addition of the ... ... travel vaccines market to grow at a CAGR of 6.83% during ... and the growth prospects of the global travel vaccines market for ... generated from the sales of various vaccines administered to actively immunize ...
(Date:12/8/2016)... Dec. 8, 2016 Australia Ophthalmic Lasers Market ... "Australia Ophthalmic Lasers Market Outlook to 2022", provides key ... report provides value, in millions of US dollars, volume ... - Excimer Lasers, Femtosecond Lasers and YAG Lasers. ... data for each of these market segements, and global ...
Breaking Medicine Technology: