Navigation Links
Researchers find common childhood asthma unconnected to allergens or inflammation
Date:5/23/2013

Asthma is a significant health problem affecting about 7 million children in the United States. Nearly 10 percent of American children 017 years of age have asthma, making it the most common serious respiratory childhood disease. Its prevalence is even higher among inner-city children, says Dr. Worgall. Besides causing suffering, disability and alarm, the economic toll is significant, he says: In 2009, asthma caused 640,000 emergency room visits and 157,000 hospitalizations, plus 10.5 million missed school days.

"Yet while it has become increasingly evident that asthma takes several forms, treatment of the disorder is uniform," he says. "Most therapies are designed to reduce inflammation, but they do not help all sufferers."

The notion that asthma has different forms gained ground after several genome-wide association studies (GWAS) found variation in a gene, later identified as ORMDL3, in to up to 30 percent of asthma cases. In 2007, over-production of the gene's protein was connected to childhood asthma, and this gene has been the most consistent genetic factor identified so far for asthma.

In 2010, a study in yeast found that ORMDL3 protein inhibits sphingolipid de-novo synthesis.

This finding prompted the researchers to investigate whether sphingolipid production is connected to asthma. Their study shows that this is indeed true in mouse models of the disease. Using mouse models, the researchers found that inhibition of an enzyme, serine palmitoyl-CoA transferase (SPT), which is critical to sphingolipid synthesis, produced asthma in mice and in human airways, as it did in mice that had a genetic defect in SPT.

The airway hyperactivity seen in the mice was not linked to increased inflammation, and the scientists saw a decreased response of the lung and airways to magnesium -- which is often used in emergency rooms to relieve chest tightness of patients with asthma attacks.

"In our mouse model
'/>"/>

Contact: John Rodgers
jdr2001@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... Los Angeles, California (PRWEB) March 31, 2015 ... Caregiver Services has started to hire more caregivers, ... public relations personnel and care managers within the ... expansion the company's training institution, 1Heart Caregiver University ... to assist with its mission to provide quality ...
(Date:3/31/2015)... As the demand for optimized mobile content continues ... mobile-friendly website online sometime during the month of May ... commitment to bring the best and most accurate information ... same great fitness information at http://www.chunkfitness.com will ... read while browsing on a mobile device. , About ...
(Date:3/31/2015)... VA (PRWEB) March 31, 2015 ... takes place from April 1-7, the Mesothelioma Applied ... its new prevention program, to complement its existing ... , “As part of the Meso Foundation’s ... extinguish fears of diseases related to asbestos, including ...
(Date:3/31/2015)... Calling all runners, walkers and everyone who ... diseases! The first annual “Lyme Walk & Run” will be ... CT. The event, hosted by Lyme Research Alliance (LRA) ... to support research and education about Lyme and other tick-borne ... and abilities, will feature 5K and 10K runs and one-mile ...
(Date:3/31/2015)... NB (PRWEB) March 31, 2015 Indosoft, developer ... of Asterisk 1.4 support in development of their 5.x line. ... for Asterisk has been deployed around the world for more ... Asterisk 1.4 as a telephony platform, Q-Suite can fully embrace ... providing quality call center software on Asterisk for more than ...
Breaking Medicine News(10 mins):Health News:1Heart Ends 1st Quarter of the Year With 1Heart Caregiver University Training of New Staff and Commits To Provide More Jobs For Year 2015 2Health News:1Heart Ends 1st Quarter of the Year With 1Heart Caregiver University Training of New Staff and Commits To Provide More Jobs For Year 2015 3Health News:Mesothelioma Research Organization Announces New Prevention Program 2Health News:Mesothelioma Research Organization Announces New Prevention Program 3Health News:Lyme Research Alliance & Tick-Borne Disease Alliance to Kick-Off 1st “Lyme Walk & Run” Event, April 26 2Health News:Indosoft Announces End of Life for Asterisk 1.4 Support in Q-Suite 5 Call Center Software 2
... Texas, Nov. 12 A Fort Worth family has been ... negligence case resulting from improper treatment to a newborn child ... Dallas County by the child,s mother, Tiffany Martinez, and alleged ... to diagnose the hip dysplasia [dislocation] and failed to provide ...
... Mesa Laboratories, Inc. (Nasdaq: MLAB ) today announced ... dividend of $.11 per share of common stock, up from ... payable December 15, 2009, to shareholders of record on November ... has maintained strong cash positions and has continued to build ...
... in day-to-day actions , THURSDAY, Nov. 12 (HealthDay News) -- ... complex decisions, from what to make for dinner to whether ... "Humans make much more complex decisions than other animals -- ... to start a family -- and we wanted to understand ...
... research published in the November issue of the ... that African-American patients with colorectal cancer are more likely ... likely to undergo surgical procedures compared with Caucasians, suggesting ... reduce differences in colorectal cancer outcomes for African-Americans. ...
... ... be crumbling, thanks to a promising new gene therapy that eliminates the ability of certain ... that inactivation of a DNA repair gene called Hus1 efficiently kills cells lacking p53 -- ... ...
... ... lecture at global Alzheimer,s conference on the groundbreaking topic of Alzheimer,s prevention. ... Naples, FL (PRWEB) ... First International Conference on Alzheimer’s Disease and Advanced Neurotechnologies on the topic of Alzheimer,s ...
Cached Medicine News:Health News:Dallas County Jury Finds in Favor of Family in Medical Malpractice Suit 2Health News:What's for Dinner? Brain Chemical Helps People Decide 2Health News:African-Americans with colorectal cancer have poorer outcomes, lower survival rates 2Health News:Cornell Researchers Identify a Weak Link in Cancer Cell Armor 2Health News: Integrative Neurologist Breaks Ground in Alzheimer's Prevention 2
(Date:3/31/2015)... -- ANI Pharmaceuticals, Inc. ("ANI") (NASDAQ: ANIP ) ... and 300mg oral tablets, indicated for use in the ... Propafenone Hydrochloride 150mg, 225mg and 300mg tablets was $14 ... Arthur S. Przybyl , President and Chief Executive Officer ... our fourth product from the portfolio of approved generic ...
(Date:3/31/2015)... March 31, 2015  Oxis International, Inc. (OXIS) (OXI.PA) ... and commercialization, announced today Oxis CEO Tony Cataldo ... Oxis common shares on the Euronext exchange. Oxis shares ... symbol OXIS.   Oxis Chairman and CEO ... move forward with its strategies launched in 2014 and ...
(Date:3/31/2015)... DUBLIN , Mar. 27, 2015 Research ... announced the addition of the "North American ... Laboratory Information System), by Type (Clinical Pathology Laboratory ... Forecast to 2019" report to their offering. ... market is estimated to grow at a CAGR ...
Breaking Medicine Technology:ANI Pharmaceuticals Announces the Launch of Propafenone Tablets 2ANI Pharmaceuticals Announces the Launch of Propafenone Tablets 3Oxis International Inc. Announces Request for Euronext Trading Suspension 2North American Laboratory Information System (Clinical Pathology Laboratory Information System, Anatomic Pathology Laboratory Information) Market 2015-2019 2North American Laboratory Information System (Clinical Pathology Laboratory Information System, Anatomic Pathology Laboratory Information) Market 2015-2019 3
... of Senior Notes in Connection with... -- ARDEE, Ireland, Sept. 24 ... ... ... ,; var first_result; // Results are keyed by longUrl, so we need to grab the first one. ...
... MSON ), a developer of state of ... used for acute health conditions, today announced plans to ... financial results on Tuesday, September 28, 2010.  Michael A. ... Senior VP and Chief Financial Officer, will host a ...
Cached Medicine Technology:Warner Chilcott Announces Pricing of $500 Million of Senior Notes in Connection with Agreement to Acquire U.S. Rights to Enablex® 2Warner Chilcott Announces Pricing of $500 Million of Senior Notes in Connection with Agreement to Acquire U.S. Rights to Enablex® 3Warner Chilcott Announces Pricing of $500 Million of Senior Notes in Connection with Agreement to Acquire U.S. Rights to Enablex® 4Warner Chilcott Announces Pricing of $500 Million of Senior Notes in Connection with Agreement to Acquire U.S. Rights to Enablex® 5Warner Chilcott Announces Pricing of $500 Million of Senior Notes in Connection with Agreement to Acquire U.S. Rights to Enablex® 6Warner Chilcott Announces Pricing of $500 Million of Senior Notes in Connection with Agreement to Acquire U.S. Rights to Enablex® 7Warner Chilcott Announces Pricing of $500 Million of Senior Notes in Connection with Agreement to Acquire U.S. Rights to Enablex® 8Misonix Schedules Fourth Quarter and Fiscal 2010 Financial Results Conference Call; September 28, 2010 at 4:30 p.m. Eastern 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: