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Researchers find clues to why some continue to eat when full
Date:12/27/2009

DALLAS Dec. 28, 2009 The premise that hunger makes food look more appealing is a widely held belief just ask those who cruise grocery store aisles on an empty stomach, only to go home with a full basket and an empty wallet.

Prior research studies have suggested that the so-called hunger hormone ghrelin, which the body produces when it's hungry, might act on the brain to trigger this behavior. New research in mice by UT Southwestern Medical Center scientists suggest that ghrelin might also work in the brain to make some people keep eating "pleasurable" foods when they're already full.

"What we show is that there may be situations where we are driven to seek out and eat very rewarding foods, even if we're full, for no other reason than our brain tells us to," said Dr. Jeffrey Zigman, assistant professor of internal medicine and psychiatry at UT Southwestern and co-senior author of the study appearing online and in a future edition of Biological Psychiatry.

Scientists previously have linked increased levels of ghrelin to intensifying the rewarding or pleasurable feelings one gets from cocaine or alcohol. Dr. Zigman said his team speculated that ghrelin might also increase specific rewarding aspects of eating.

Rewards, he said, generally can be defined as things that make us feel better.

"They give us sensory pleasure, and they motivate us to work to obtain them," he said. "They also help us reorganize our memory so that we remember how to get them."

Dr. Mario Perello, postdoctoral researcher in internal medicine and lead author of the current study, said the idea was to determine "why someone who is stuffed from lunch still eats and wants to eat that high-calorie dessert."

For this study, the researchers conducted two standard behavioral tests. In the first, they evaluated whether mice that were fully sated preferred a room where they had previously found high-fat food over one that
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Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

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