Navigation Links
Researchers find changes to protein SirT1
Date:1/27/2014

Researchers find changes to protein SirT1 can prevent excess metabolic stress associated with obesity, diabetes and aging.

Studies have suggested that the protein SirT1 may be protective in metabolic diseases and the effects of aging, and diminished SirT1 activity has been reported in various disease models including diabetes and metabolic syndrome. Maintaining a normal level of this protein may be effective in preventing obesity- and age-related diseases.

Metabolic stress caused by obesity, diabetes and aging increases a small molecule, glutathione that reacts with SirT1, inhibiting its activity. In a recent paper published online in the Journal of Biological Chemistry, Boston University School of Medicine (BUSM) researchers have demonstrated that by changing three of the amino acids on SirT1 they could produce a "super-sirt" which functioned normally despite the metabolic stress.

"In the process of preventing the effects of the stress occasioned by metabolic excess typical of obesity, diabetes and aging, the enzyme function of SirT1 can be destroyed by the very metabolic stress it is trying to overcome," says Richard Cohen, MD, professor of medicine and director of the section of vascular biology at BUSM. "This study establishes that stresses associated with excess metabolism can be circumvented by changing the protein, or by preventing the glutathione reaction with the protein."


'/>"/>

Contact: GinaDiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers use sensory integration model to understand unconscious priming
2. CWRU researchers find epileptic activity spreads in new way
3. IU School of Medicine researchers awarded $300,000 GE/NFL grant to study concussions
4. UGA researchers discover origin of unusual glands in the body
5. Air Force awards over $1 million to UC trauma researchers
6. UCLA researchers develop risk calculator to predict survival in heart failure patients
7. Mount Sinai researchers find promising new drug targets for cocaine addiction
8. Researchers identify possible explanation for link between exercise & improved prostate cancer outcomes
9. Researchers awarded grant from the DeGregorio Family Foundation
10. Penn researchers run successful HIV intervention project in S. Africa
11. Not just clean but spotless -- Researchers show how cells tidy up
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a weight ... app plans to fix the two major problems leading the fitness industry today:, ... program , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... "With 30 ... their specific project," said Christina Austin - CEO of Pixel Film Studios. , ... and all within Final Cut Pro X . Simply select a ProHand generator ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether ... latter, setting the bar too high can result in disappointment, perhaps even self-loathing. However, ... their goal. , Research from PsychTests.com reveals that behind the tendency ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
(Date:6/24/2016)... TX (PRWEB) , ... June 24, 2016 , ... People ... part in Genome magazine’s Code Talker Award, an essay contest in which patients and ... an award to be presented at the 2016 National Society of Genetic Counselors (NSGC) ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 The vast majority ... outpatient dialysis facility.  Treatments are usually 3 times a ... per visit, including travel time, equipment preparation and wait ... but especially grueling for patients who are elderly and ... skilled nursing and rehabilitation centers for some duration of ...
(Date:6/23/2016)... FRANKLIN, Tenn. , June 23, 2016 ... for automating, integrating and transforming the patient ... launch of several innovative new products and ... depth of its revenue cycle offerings. These ... establish more efficient workflows, remain compliant in ...
(Date:6/23/2016)... 2016  The National Pharmaceutical Council (NPC) today ... policy research organization as its newest member.  ... vice president and chief scientific officer, Mallinckrodt Pharmaceuticals, ... NPC Board of Directors. ... joined us in support of our efforts to ...
Breaking Medicine Technology: