Navigation Links
Researchers find CDT biomarker ineffective for identifying unhealthy alcohol use
Date:6/20/2011

(Boston) Researchers from Boston University School of Medicine (BUSM) have found that among HIV-infected adults with alcohol problems, measuring their carbohydrate-deficient transferrin (CDT) biomarker was a poor and inaccurate method for detecting unhealthy drinking. These findings currently appear on-line in AIDS Care.

Unhealthy alcohol use is common in HIV-infected persons. It can interfere with HIV medication adherence, may lower CD4 cell count and can cause hepatic injury. Furthermore, HIV co-infection with viral hepatitis is common and both HIV and viral hepatitis are adversely impacted by alcohol. For these reasons, detection of unhealthy alcohol use is important in the clinical care of HIV-infected individuals.

Some clinicians are interested in having a laboratory test that can detect unhealthy alcohol use. Although CDT, often measured as %CDT, can detect very heavy drinking, whether it does so in people with HIV in a clinically useful manner has yet to be established. The researchers evaluated the ability of %CDT and gamma glutamyltransferase to detect three levels of unhealthy alcohol consumption: "at-risk", "heavy" and "frequent heavy" drinking as determined by the reference standard Timeline Followback questionnaire.

Of the 300 subjects, 103 reported current consumption at "at-risk" amounts, and 47 reported "heavy" amounts. For "at-risk" drinking, sensitivity of %CDT was 28 percent, meaning the test detected only 28 percent of those with unhealthy alcohol use. For "heavy" drinking, sensitivity was 36 percent. According to the researchers, these findings suggest that %CDT is not sufficiently sensitive for use in screening for unhealthy alcohol use by people with HIV infection.

"There is evidence that early intervention for unhealthy alcohol use can be effective but early clinical signs are often missed and unhealthy alcohol use often goes undiagnosed by HIV healthcare providers," explained principal investigator Jeffrey Samet, MD, MA, MPH, a professor of medicine at BUSM. "Unfortunately among HIV-infected adults with alcohol problems, %CDT had poor overall accuracy for detecting unhealthy drinking," he added.

Samet and his colleagues believe the next steps for research might include testing other biomarkers for this purpose. "Numerous self-report questionnaires have been validated for detecting unhealthy alcohol use. In the mean time, these will likely remain the least expensive, most accurate and most easily implemented tools for screening patients with HIV for unhealthy alcohol use," said senior author Richard Saitz, MD, MPH, FACP, FASAM, a professor of medicine at BUSM.


'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. Mayo Clinic researchers use human vaccine to cure prostate cancer in mice
2. UT Southwestern researchers uncover why ketamine produces a fast antidepressant response
3. Researchers report progress using iPS cells to reverse blindness
4. Researchers warn of fever from the forest
5. NIH researchers find new clues about aging
6. Routine screening for autism not needed: McMaster researchers
7. Researchers work to turn back the clock on bone-producing stem cells
8. U-M researchers advocate national strategic approach to therapeutic cancer vaccines
9. Rhode Island and Miriam researchers say patient gender may influence nuclear stress test referrals
10. Researchers discover biochemical weakness of malaria parasite -- vaccine to be developed
11. Researchers find that inhibiting microRNAs may help prevent degenerative eye disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... CT (PRWEB) , ... March 22, 2017 , ... ... historic plan to cure Rett Syndrome, a devastating neurological disorder that afflicts 350,000 ... MECP2, located on the X chromosome, and almost exclusively strikes females. Following ...
(Date:3/22/2017)... ... 22, 2017 , ... Drs. Jennifer Houck, Lauren Smith, Heather Johnson and the ... in need of skilled pediatric dentistry in Rock Hill, SC, without a ... routine treatments, including cavities, sealants and fluoride applications, in a comfortable and fun environment. ...
(Date:3/22/2017)... York (PRWEB) , ... March 22, 2017 , ... ... Hospital have entered into a research collaboration to translate advances in basic neuroscience ... impairments at Blythedale and beyond. The collaboration seeks to improve movement, vision, and cognition ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... ... imaging core lab with extensive therapeutic experience and operational excellence in oncology clinical ... immuno-oncology clinical trial for the treatment of non-small cell lung cancer and small ...
(Date:3/22/2017)... ... March 22, 2017 , ... SNL Insurance ... to families and business owners in the greater Hampton Roads area, is embarking ... Society Relay For Life event. , Each year, hundreds of people living in ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... , March 22, 2017 FinancialBuzz.com News ... According to ... was worth an estimated $6.6 billion in 2016, and is projected ... or reaching more than $24 billion by 2025. The medical cannabis ... growing from $4.7 billion in 2016, to an estimated $13.3 billion ...
(Date:3/22/2017)... 2017 EMD Serono, the biopharmaceutical business of Merck ... and Canada , today announced two new ... session at the 65 th Annual Pacific Coast Reproductive ... on March 24 th .   The results ... collected from July 2009 to December 2015 containing data from ...
(Date:3/22/2017)... MarketNewsUpdates.com News Commentary  ... As ... oil continues to rise in popularity with consumers, Cannabis ... enhancing production through acquiring innovative assets and other plant ... include: Future Farm Technologies Inc (OTC: FFRMF) (CSE: FFT.CN), mCig, ...
Breaking Medicine Technology: