Navigation Links
Researchers find CDT biomarker ineffective for identifying unhealthy alcohol use
Date:6/20/2011

(Boston) Researchers from Boston University School of Medicine (BUSM) have found that among HIV-infected adults with alcohol problems, measuring their carbohydrate-deficient transferrin (CDT) biomarker was a poor and inaccurate method for detecting unhealthy drinking. These findings currently appear on-line in AIDS Care.

Unhealthy alcohol use is common in HIV-infected persons. It can interfere with HIV medication adherence, may lower CD4 cell count and can cause hepatic injury. Furthermore, HIV co-infection with viral hepatitis is common and both HIV and viral hepatitis are adversely impacted by alcohol. For these reasons, detection of unhealthy alcohol use is important in the clinical care of HIV-infected individuals.

Some clinicians are interested in having a laboratory test that can detect unhealthy alcohol use. Although CDT, often measured as %CDT, can detect very heavy drinking, whether it does so in people with HIV in a clinically useful manner has yet to be established. The researchers evaluated the ability of %CDT and gamma glutamyltransferase to detect three levels of unhealthy alcohol consumption: "at-risk", "heavy" and "frequent heavy" drinking as determined by the reference standard Timeline Followback questionnaire.

Of the 300 subjects, 103 reported current consumption at "at-risk" amounts, and 47 reported "heavy" amounts. For "at-risk" drinking, sensitivity of %CDT was 28 percent, meaning the test detected only 28 percent of those with unhealthy alcohol use. For "heavy" drinking, sensitivity was 36 percent. According to the researchers, these findings suggest that %CDT is not sufficiently sensitive for use in screening for unhealthy alcohol use by people with HIV infection.

"There is evidence that early intervention for unhealthy alcohol use can be effective but early clinical signs are often missed and unhealthy alcohol use often goes undiagnosed by HIV healthcare providers," explained principal investigator Jeffrey Samet, MD, MA, MPH, a professor of medicine at BUSM. "Unfortunately among HIV-infected adults with alcohol problems, %CDT had poor overall accuracy for detecting unhealthy drinking," he added.

Samet and his colleagues believe the next steps for research might include testing other biomarkers for this purpose. "Numerous self-report questionnaires have been validated for detecting unhealthy alcohol use. In the mean time, these will likely remain the least expensive, most accurate and most easily implemented tools for screening patients with HIV for unhealthy alcohol use," said senior author Richard Saitz, MD, MPH, FACP, FASAM, a professor of medicine at BUSM.


'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. Mayo Clinic researchers use human vaccine to cure prostate cancer in mice
2. UT Southwestern researchers uncover why ketamine produces a fast antidepressant response
3. Researchers report progress using iPS cells to reverse blindness
4. Researchers warn of fever from the forest
5. NIH researchers find new clues about aging
6. Routine screening for autism not needed: McMaster researchers
7. Researchers work to turn back the clock on bone-producing stem cells
8. U-M researchers advocate national strategic approach to therapeutic cancer vaccines
9. Rhode Island and Miriam researchers say patient gender may influence nuclear stress test referrals
10. Researchers discover biochemical weakness of malaria parasite -- vaccine to be developed
11. Researchers find that inhibiting microRNAs may help prevent degenerative eye disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... August 18, 2017 , ... Mediaplanet today ... for active, healthy lifestyles and highlighting the importance of proactive eye and ear ... and shares the latest innovations in hearing aid technology. , In this ...
(Date:8/18/2017)... ... ... The Dawn Johnson Insurance Group, a Missouri-based insurance and financial planning firm headquartered ... efforts to educate the local population on cancer realities while attracting donations to be ... Each day in America, roughly 4,600 new cases of cancer are diagnosed and more ...
(Date:8/18/2017)... ... August 18, 2017 , ... Radabaugh & ... assistance to communities in North-Central West Virginia, is embarking on a cooperative charity ... in the area. , The Chestnut Mountain Ranch (CMR) is a Christ-centered boarding ...
(Date:8/18/2017)... ... 2017 , ... MLM Insurance Group, a Miami area provider ... is working to support the Take Stock In Children Foundation during a regional ... The Take Stock In Children Foundation (TSC) offers guidance and assistance to low ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... and financial planning firm that serves residential and commercial clients in the greater ... drive to raise community support for the fight against cancer. , Founded by ...
Breaking Medicine News(10 mins):
(Date:8/11/2017)... Aug. 11, 2017 DarioHealth Corp. (NASDAQ: DRIO), ... and big data solutions, today announced that it will ... 14 and host a conference call at 9:00am ET. ... and financial results and its strategy and outlook for ... by Erez Raphael , Chief Executive Officer, and ...
(Date:8/8/2017)... Second-quarter 2017 revenues of $876 million ... continuing operations Second-quarter 2017 ... million Second-quarter 2017 Sterile ... Second-quarter 2017 adjusted diluted earnings ... to $0.93 Second-quarter 2017 ...
(Date:8/7/2017)... 7, 2017 Diplomat Pharmacy, Inc. (NYSE: ... as president, effective Aug. 7, 2017. ... to pursue other interests and will serve as president emeritus ... has served us in multiple leadership roles since he joined ... 2015 and has provided decisive, strategic leadership which continues to ...
Breaking Medicine Technology: