Navigation Links
Researchers explore the emerging role of infection in Alzheimer's disease
Date:5/22/2008

May 22, 2008, Amsterdam A number of chronic diseases are in fact caused by one or more infectious agents. For example, stomach ulcers are caused by Helicobacter pylori, chronic lung disease in newborns and chronic asthma in adults are both caused by Mycoplasmas and Chlamydia pneumonia, while some other pathogens have been associated with atherosclerosis. The realization that pathogens can produce slowly progressive chronic diseases has opened new lines of research into Alzheimers disease.

In a special issue of the Journal of Alzheimers Disease published May 2008, guest editors Judith Miklossy, from The University of British Columbia, and Ralph N. Martins, from Edith Cowan University and Hollywood Private Hospital, Perth, Western Australia, and a group of experts explore this exciting topic.

Alzheimers disease (AD), the most frequent cause of dementia, is a form of amyloidosis. It has been known for a century that dementia, brain atrophy and amyloidosis can be caused by chronic bacterial infections, namely by Treponema pallidum in the atrophic form of general paresis in syphilis. Bacteria and viruses are powerful stimulators of inflammation. It was suggested by Alois Alzheimer and his colleagues a century ago that microorganisms may be contributors in the generation of senile plaques in AD.

The fact that pathogens may suppress, subvert or evade host defenses and establish chronic or latent infection has received little attention in the past. During infection, active oxygen and nitrogen species generated by inflammatory cells may cause DNA damage, induce apoptosis, and modulate enzyme activities and gene expression. Depending upon the biology of the pathogen and the host defense mechanisms the organism can persist in the infected tissues and cause chronic inflammation and amyloid deposition. The outcome of infection is as much determined by the genetic predisposition of the patient as by the virulence and biology of the infecting agent. Environmental factors and nutrition are critical determinants of disease expression as well.

In this special issue a series of reviews draws attention to both historic and recent observations related to this emerging field of AD research. The first review shows the importance of chronic inflammation in AD, followed by three articles presenting evidence on the involvement of spirochetes, Chlamydia pneumoniae and Herpes simplex virus type 1 in AD. These are followed by a review of amyloid proteins, which occur in many cellular forms in Eukaryotes and Prokaryotes.

The link between several viral and bacterial infections and the most significant genetic factor for AD, APOE 4, is discussed in the next review. The link between excessive or misplaced iron and a variety of neurodegenerative diseases and infection is reviewed in the final article.

According to Miklossy and Martins, The historic and new observations reviewed in this special issue clearly show that high priority should be given for further research in this field as it may have major implications for public health, treatment, and prevention as adequate anti-bacterial and anti-viral drugs are available. Treatment of a bacterial infection and associated viral infection may result in regression and, if started early, prevention of disease. The impact on reducing healthcare costs would be substantial.


'/>"/>

Contact: Astrid Engelen
a.engelen@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Related medicine news :

1. 2 LA BioMed researchers named Heroes of Emergency Medicine
2. Virtual biopsy can tell whether colon polyp is benign without removal, Mayo researchers say
3. Researchers close in on new melanoma gene
4. Traditional herbal medicine kills pancreatic cancer cells, Jefferson researchers report
5. Researchers develop first transgenic monkey model of Huntingtons disease
6. Researchers expand natural killer cells in cord blood to fight leukemia
7. Medical College of Wisconsin researchers identify proteins that help develop mammalian hearts
8. Mastectomies on the rise and MRI use may explain part of the trend, say Mayo researchers
9. UCSD researchers show link between vitamin D status, breast cancer
10. Researchers find first conclusive evidence of Alzheimers-like brain tangles in nonhuman primates
11. Vancouver researchers discover missing link between TB bacteria and humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/30/2016)... ... November 30, 2016 , ... Standard ... 75, an annual ranking and recognition of the largest closely held companies headquartered ... ranked from 2008-2016. In addition, Standard Process was awarded the Talent Award for ...
(Date:11/30/2016)... ... November 30, 2016 , ... Center For ... announced the opening of a new residential mental health treatment program in Chino ... issues such as severe anxiety, depression, bi-polar disorder, and other related issues. , ...
(Date:11/30/2016)... ... 30, 2016 , ... The Cronovo Smartwatch, the first on ... consumers at an affordable price, is now available on the crowdfunding website ... game changer” when it comes to the smartwatch. , "With Cronovo, we’ve combined ...
(Date:11/30/2016)... ... 2016 , ... The Valley’s leading orthopedic practice, OrthoArizona - ... North Phoenix and Chandler locations. , The new North Phoenix location is located ... 3rd St, Suite 300 in Phoenix. The practice’s new Chandler location is conveniently ...
(Date:11/30/2016)... ... November 30, 2016 , ... BrightStar Care of Wellington , a ... was recently named the 2016 Provider and Employer of Choice by Home Care Pulse. ... scores, and only providers with the highest quality receive the Best of Home Care ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2016 According to a ... by Product (Instruments, Reagents, Software), Technology (Immunoassay, Clinical ... Nephrology, Infectious Diseases) - Forecast to 2021" published ... USD 60.22 Billion in 2016. This market is ... during the forecast period (2016-2021) to reach USD ...
(Date:12/2/2016)... In the first ever attempt to include ... from C. sativa, the Hebrew University in Jerusalem, the ... II , the Universita` del Piemonte Orientale and Phytoplant ... and unified inventory of phytocannabinoids of different botanical origin. ... remarkable chemical and structural diversity of phytocannabinoids. As a ...
(Date:12/2/2016)... , Dec. 2, 2016  Eli Lilly and ... financial guidance for 2017 and provide updated financial guidance ... also conduct a conference call on that day with ... company,s financial guidance. The conference call will ... general public can access a live webcast of the ...
Breaking Medicine Technology: