Navigation Links
Researchers explore the emerging role of infection in Alzheimer's disease
Date:5/22/2008

May 22, 2008, Amsterdam A number of chronic diseases are in fact caused by one or more infectious agents. For example, stomach ulcers are caused by Helicobacter pylori, chronic lung disease in newborns and chronic asthma in adults are both caused by Mycoplasmas and Chlamydia pneumonia, while some other pathogens have been associated with atherosclerosis. The realization that pathogens can produce slowly progressive chronic diseases has opened new lines of research into Alzheimers disease.

In a special issue of the Journal of Alzheimers Disease published May 2008, guest editors Judith Miklossy, from The University of British Columbia, and Ralph N. Martins, from Edith Cowan University and Hollywood Private Hospital, Perth, Western Australia, and a group of experts explore this exciting topic.

Alzheimers disease (AD), the most frequent cause of dementia, is a form of amyloidosis. It has been known for a century that dementia, brain atrophy and amyloidosis can be caused by chronic bacterial infections, namely by Treponema pallidum in the atrophic form of general paresis in syphilis. Bacteria and viruses are powerful stimulators of inflammation. It was suggested by Alois Alzheimer and his colleagues a century ago that microorganisms may be contributors in the generation of senile plaques in AD.

The fact that pathogens may suppress, subvert or evade host defenses and establish chronic or latent infection has received little attention in the past. During infection, active oxygen and nitrogen species generated by inflammatory cells may cause DNA damage, induce apoptosis, and modulate enzyme activities and gene expression. Depending upon the biology of the pathogen and the host defense mechanisms the organism can persist in the infected tissues and cause chronic inflammation and amyloid deposition. The outcome of infection is as much determined by the genetic predisposition of the patient as by the virulence and biology of the infecting agent
'/>"/>

Contact: Astrid Engelen
a.engelen@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. 2 LA BioMed researchers named Heroes of Emergency Medicine
2. Virtual biopsy can tell whether colon polyp is benign without removal, Mayo researchers say
3. Researchers close in on new melanoma gene
4. Traditional herbal medicine kills pancreatic cancer cells, Jefferson researchers report
5. Researchers develop first transgenic monkey model of Huntingtons disease
6. Researchers expand natural killer cells in cord blood to fight leukemia
7. Medical College of Wisconsin researchers identify proteins that help develop mammalian hearts
8. Mastectomies on the rise and MRI use may explain part of the trend, say Mayo researchers
9. UCSD researchers show link between vitamin D status, breast cancer
10. Researchers find first conclusive evidence of Alzheimers-like brain tangles in nonhuman primates
11. Vancouver researchers discover missing link between TB bacteria and humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2014)... orphaned by HIV/AIDS in South Africa may provide insight ... behavior issues in other areas of the world, which ... that could lead to successful interventions. , A ... United Nations mentions that due to the HIV/AIDS pandemic, ... African, children are at an increased risk for mental ...
(Date:4/14/2014)... A new study shows that moderate to severe ... risk of stroke, cancer and death. , Results of ... to severe obstructive sleep apnea were four times more ... times more likely to have a stroke (HR = ... (HR = 3.4), and 2.5 times more likely to ...
(Date:4/14/2014)... Dallas study involving serious youth offenders, the answer to one ... seven years: "How long do you think you,ll live?", According ... offending over time., Author Dr. Alex Piquero said the study ... of them offend at very high rates and commit more ... much later in life offend much less., "In a lot ...
(Date:4/14/2014)... with symptoms increasing dramatically during some of the most important ... has found. , Depressive symptoms increased on average by 68 ... young men, who were around 25 years old when they ... their children. The results of the study were published April ... is the first to identify when young fathers are at ...
(Date:4/14/2014)... Lower weight babies and babies who aren,t breastfed ... risk of developing chronic inflammation and related health ... study. , "There were good reasons to hypothesize ... inflammation in adulthood," says Thomas McDade (Northwestern University), ... in the Child & Brain Development program. "It ...
Breaking Medicine News(10 mins):Health News:Researchers identify children with emotional behavior difficulties 2Health News:Researchers identify children with emotional behavior difficulties 3Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2Health News:UT Dallas study: Youth who fail to envision future commit more crimes 2Health News:Young dads at high risk of depression, too 2Health News:Low birth weight, less breastfeeding create later health risks 2
... A rare genetic disorder may be responsible for causing strokes ... using enzyme replacement// treatment, says a study. ,The ... burning pain in the hands and feet, dark nodular skin ... by a missing or faulty enzyme needed by the body ...
... condition worse and it is in a position to recruit ... makeup the shortfall. Most strugglers were the remote and rural ... female part-time GPs, more workloads and immence retirement of a ... shortage’. ,Dr Brian McKinstry, a senior research ...
... that radiotherapy given in large dosage but in small amounts ... and US said that 13 larger doses were found to ... the conventional regime of 25 small doses. The findings were ... by the Cancer Research UK. They analysed 1,410 women and ...
... over 4,000 people dying in road traffic accidents in the ... senior Delhi Police official. , ,"This city has a ... difficult to control and coordinate the traffic if the standard ... joint commissioner, traffic, said. ,He also said that about ...
... 25 junior doctors here who have been protesting the ... other backward classes have sought// President A.P.J. Abdul Kalam's ... to the president seeking his "permission to immolate themselves", ... ,Four of the junior doctors sitting on ...
... alcohol may reduce the risk of heart disease than for ... it is applicable only for men and women are deprived ... patterns and heart health among men and women, but an ... and should not be used to justify potentially harmful drinking ...
Cached Medicine News:Health News:Rare Genetic Disorder Could Cause Strokes In Young People 2Health News:Scotland Faces Shortage Of GPs 2Health News:Road Traffic Accidents Kill 4,000 people in Delhi 2Health News:Daily Intake Of Alcohol Reduces Heart Disease In Men Than Women 2
(Date:1/15/2014)... 2014  Manufacturers, suppliers and distributors of ... able to protect their most important business ... http://photos.prnewswire.com/prnh/20130716/CL46586LOGO ) Because ... Device Industry, it steadfastly remains one of ... involving IP infringement. This litigious nature can ...
(Date:1/15/2014)... 2014 Tegra Medical is very pleased to ... as its new Chief Executive Officer.  Mark was ... in which he has overseen the company,s four facilities ... , and Costa Rica.  Mr. King joined Tegra ... sales, engineering and manufacturing experience in medical device businesses, ...
(Date:1/15/2014)... , Jan. 15, 2014  Echo Therapeutics, ... medical device company developing its Symphony® CGM System ... today announced that Robert F. Doman , ... will present at "TEN", Noble Financial Capital Markets, ... Doman will make a corporate presentation to prospective ...
Breaking Medicine Technology:Intellectual Property Insurance for Medical-related Products and Services 2Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3
... (NYSE: CRY ), an implantable biological medical device ... the fourth quarter and the full year of 2010.  Revenues ... quarter record of $29.2 million compared to $28.6 million for ... pleased to experience yet another record in annual revenues and ...
... 2011 Orexigen® Therapeutics, Inc. (Nasdaq: OREX ) ... president, Finance, CFO and treasurer. Mr. Cooper, who has been ... the Company for personal reasons.  He has been commuting from ... in 2006.  Mr. Cooper will remain in his current role ...
Cached Medicine Technology:CryoLife Posts Record Annual Revenues of $116.6 Million 2CryoLife Posts Record Annual Revenues of $116.6 Million 3CryoLife Posts Record Annual Revenues of $116.6 Million 4CryoLife Posts Record Annual Revenues of $116.6 Million 5CryoLife Posts Record Annual Revenues of $116.6 Million 6CryoLife Posts Record Annual Revenues of $116.6 Million 7CryoLife Posts Record Annual Revenues of $116.6 Million 8CryoLife Posts Record Annual Revenues of $116.6 Million 9CryoLife Posts Record Annual Revenues of $116.6 Million 10CryoLife Posts Record Annual Revenues of $116.6 Million 11CryoLife Posts Record Annual Revenues of $116.6 Million 12CryoLife Posts Record Annual Revenues of $116.6 Million 13CryoLife Posts Record Annual Revenues of $116.6 Million 14CryoLife Posts Record Annual Revenues of $116.6 Million 15Orexigen® Therapeutics, Inc. Announces Upcoming Departure of Chief Financial Officer 2Orexigen® Therapeutics, Inc. Announces Upcoming Departure of Chief Financial Officer 3
... onboard rail clamps mount ... tables and stretchers. The ... need for lifting. Easy ... stable surface combined with ...
The DHS Basic Set is available with either self-tapping or non-self-tapping screws. Either instrument set provides complete instrumentation in one graphic case for use with the Universal Implant Set,...
... is a versatile, fully powered orthopaedic and ... traction facilities, a powered centre break and ... versatile too. ,<br.,In fact the RX600 is ... it is for traction procedures. The RX600 ...
... orthopedic trauma procedures. Part of the ... trauma table top provides a complete, ... positioning and provides for skin or ... hip pinnings; femur, supine or lateral ...
Medicine Products: