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Researchers explore the antidepressant effects of ketamine
Date:2/21/2008

n ketamine, its use also has significant drawbacks. According to John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, the only NMDA receptor antagonist found to be effective so far, ketamine, produces transient changes in perception and impairments in cognition. It is also in the same class of drugs as PCP (phencyclidine) and can cause hallucinations, among other side effects. Dr. Krystal notes that it is possible that drugs that directly enhance the activity of AMPA glutamate receptors, the AMPAkines, would have antidepressant effects similar to ketamine, without the unwanted side effects. Exploring the antidepressant effects of the AMPAkines will now be an important target for researchers.


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Contact: Jayne Dawkins
ja.dawkins@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

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