Navigation Links
Researchers explore PKC role in lung disease
Date:2/25/2013

New research examines the role of PKC in airway smooth muscle contraction and raises the possibility that this enzyme could be a therapeutic target for treating asthma, COPD, and other lung diseases.

In the lungs, pathological increases in the contraction of the smooth muscle cells (SMCs) lining airway wallsa process that decreases airflowcontribute to the chain of events leading to asthma and COPD, two common lung diseases. Jose Perez-Zoghbi and colleagues from Texas Tech University Health Sciences Center designed a series of experiments to investigate the role of the enzyme PKC in this process. The results, which appear in The Journal of General Physiology, provide new insight into the mechanisms involved in regulating luminal diameter of small airways and reveal PKC as a potential target for drug therapies.

The researchers used phase-contrast video microscopy, confocal microscopy, Western blot analysis, and pharmacological activators and inhibitors to investigate the role of PKC in airway SMC contraction in mouse lung slices. Their results suggest that activation of PKC in small airways promotes an influx of calcium into SMC and subsequent intracellular release of calcium ions to generate low frequency SMC twitching. PKC activation also induces a strong calcium ion sensitization of contraction, eliciting a stronger contractile response to stimuli that increase free intracellular calcium. Consequently, PKC activation downstream of various molecules, such as thrombin, that are present in the airways in conjunction with inflammatory lung diseases, could sensitize the airway SMCs to contractile stimuli and contribute to the airway hyper responsiveness that is characteristic of asthma and COPD.


'/>"/>

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related medicine news :

1. Baylor University researchers study barriers, resources to physical activity in Texas towns
2. Researchers identify variations in 4 genes associated with an increased risk of colorectal cancer
3. Researchers identify variations in four genes associated with an increased risk of colorectal cancer
4. NIH-funded researchers begin trial of Shigella vaccine candidates
5. Moffitt researchers say silencing of retinoblastoma gene regulates differentiation of myeloid cells
6. Researchers guardians of trust in biobank research
7. Researchers Detect an Anti-Autism Advantage in Females
8. Einstein researchers present on imaging advances
9. Researchers at St. Michaels Hospital test tool for screening cancer patients for malnutrition
10. Researchers uncover new findings on genetic risks of Behçets disease
11. Moffitt researchers find potential new therapeutic target for treating non-small cell lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers explore PKC role in lung disease
(Date:2/18/2017)... , ... February 17, 2017 , ... ... source of disruptive innovation in the industry, according to the recent NEJM Catalyst ... based on surveys of the NEJM Catalyst Insights Council, a qualified group of ...
(Date:2/18/2017)... CA (PRWEB) , ... February 18, 2017 , ... ... paragraph presets. Use Pixel Film Studios ’ ProParagraph Fashion Volume 2 ... and so many other applications. Users can pick and choose from hand-crafted ...
(Date:2/17/2017)... ... February 17, 2017 , ... The Alliance Healthcare ... designed to further positively impact the health and wellness of our community in ... it our duty to seriously consider releasing our assets beyond our 5% targeted ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... Dr. Carol Francis' goals for each and every seminar, session and class ... will demonstrate five different brainwave tools which help energize creativity, focus mental functions, ...
(Date:2/17/2017)... WASHINGTON (PRWEB) , ... February 17, 2017 , ... ... communities by fall 2017 season , Trinity Health and the U.S. Soccer Foundation ... for Success program in underserved communities. Soccer for Success, the Foundation’s soccer mentoring ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... -- Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ) (TSX: ... executive management will participate in the RBC Capital Markets ... Adrian Adams , Chief Executive Officer, will provide ... time on Wednesday, February 22, 2017. A ... be accessed from the Investors section of the Aralez ...
(Date:2/16/2017)... WOONSOCKET, R.I. , Feb. 16, 2017  Newly ... CVS ) Research Institute emphasizes the role a private ... improving public health. The study, published online today in ... that the Company,s decision to remove tobacco from all ... across all retail settings with an even greater impact ...
(Date:2/16/2017)... REDWOOD CITY, Calif. , Feb. 16, 2017 ... ), a specialty pharmaceutical company focused on the ... treatment of moderate-to-severe acute pain, announced that ... executive officer and a member of the company,s ... Mr. Angotti brings over two decades of experience ...
Breaking Medicine Technology: