Navigation Links
Researchers explore PKC role in lung disease
Date:2/25/2013

New research examines the role of PKC in airway smooth muscle contraction and raises the possibility that this enzyme could be a therapeutic target for treating asthma, COPD, and other lung diseases.

In the lungs, pathological increases in the contraction of the smooth muscle cells (SMCs) lining airway wallsa process that decreases airflowcontribute to the chain of events leading to asthma and COPD, two common lung diseases. Jose Perez-Zoghbi and colleagues from Texas Tech University Health Sciences Center designed a series of experiments to investigate the role of the enzyme PKC in this process. The results, which appear in The Journal of General Physiology, provide new insight into the mechanisms involved in regulating luminal diameter of small airways and reveal PKC as a potential target for drug therapies.

The researchers used phase-contrast video microscopy, confocal microscopy, Western blot analysis, and pharmacological activators and inhibitors to investigate the role of PKC in airway SMC contraction in mouse lung slices. Their results suggest that activation of PKC in small airways promotes an influx of calcium into SMC and subsequent intracellular release of calcium ions to generate low frequency SMC twitching. PKC activation also induces a strong calcium ion sensitization of contraction, eliciting a stronger contractile response to stimuli that increase free intracellular calcium. Consequently, PKC activation downstream of various molecules, such as thrombin, that are present in the airways in conjunction with inflammatory lung diseases, could sensitize the airway SMCs to contractile stimuli and contribute to the airway hyper responsiveness that is characteristic of asthma and COPD.


'/>"/>

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related medicine news :

1. Baylor University researchers study barriers, resources to physical activity in Texas towns
2. Researchers identify variations in 4 genes associated with an increased risk of colorectal cancer
3. Researchers identify variations in four genes associated with an increased risk of colorectal cancer
4. NIH-funded researchers begin trial of Shigella vaccine candidates
5. Moffitt researchers say silencing of retinoblastoma gene regulates differentiation of myeloid cells
6. Researchers guardians of trust in biobank research
7. Researchers Detect an Anti-Autism Advantage in Females
8. Einstein researchers present on imaging advances
9. Researchers at St. Michaels Hospital test tool for screening cancer patients for malnutrition
10. Researchers uncover new findings on genetic risks of Behçets disease
11. Moffitt researchers find potential new therapeutic target for treating non-small cell lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers explore PKC role in lung disease
(Date:7/29/2014)... WA (PRWEB) July 29, 2014 Award-winning inventor ... , a flatulence neutralizer specifically designed to absorb embarrassing odors ... charcoal that can easily be stored in a desk drawer. ... use the PoofPad, users will simply sit on the pad ... gas at the office and then BAM, someone appears out ...
(Date:7/29/2014)... 2014 Riverdale Urgent Care is making ... Through their presence at local events, partnerships and other ... than just a medical service for the Riverdale neighborhood. ... in support of Riverdale RiverFest and South Riverdale Street ... features local musicians and entertainers, arts and crafts, boat ...
(Date:7/29/2014)... July 29, 2014 Lean and Lovely, an ... for women who want to wear a bikini in the ... Stevenson, prompting an investigative review. , “Our Lean and ... for women at all fitness levels. Neither your age nor ... unfit your body is at the beginning, you will achieve ...
(Date:7/29/2014)... Current Back2Basics long-term drug rehab resident Jon B. ... his first six months of sobriety. , This was ... foot, once on the other– which was how he became ... ago and was prescribed drugs that I didn’t take properly.” ... home who’d recently completed the program. The six-month long residential ...
(Date:7/29/2014)... 29, 2014 PeopleKeys today announced that ... teach students how to train and certify others in ... Behavioral Consultant Trainer , will be taught by PeopleKeys ... Training John Schindell as a live Tele-course over the ... The Certified Behavioral Consultant Trainer course will use a ...
Breaking Medicine News(10 mins):Health News:Award-Winning Inventor Michael Croix Launches an Indiegogo Campaign for PoofPad 2Health News:Award-Winning Inventor Michael Croix Launches an Indiegogo Campaign for PoofPad 3Health News:Riverdale Urgent Care of the Bronx, NY Puts a Face Back on Medicine 2Health News:Riverdale Urgent Care of the Bronx, NY Puts a Face Back on Medicine 3Health News:Lean and Lovely: Review Examining Neghar Fonooni’s Program Released 2Health News:Back2Basics Sober Living Resident Overcomes Obstacle in Early Sobriety 2Health News:PeopleKeys Announces New Certified Behavioral Consultant Trainer Course 2Health News:PeopleKeys Announces New Certified Behavioral Consultant Trainer Course 3
... contaminated fish are enormous and especially children and women ... much// and which fish they eat says-"The Madison Declaration ... of the international science journal Ambio. ,Developed ... Global Pollutant last August in Madison, Wis., the declaration ...
... of different biomolecules (DNA, proteins, etc.) has been created ... technology makes possible the development of low-cost clinical bedside ... customizable particles, could also be used for disease monitoring, ... are thinner than the width of a human hair, ...
... variety of autoimmune diseases that are aggravated when one ... cell, malfunctions. In humans, one cause of this malfunction ... the immune cells’ ability to function. In a new ... the National Academy of Sciences, researchers at the University ...
... bulb turning on in the head. Scientists have reversed this ... light shines on it. ,The unexpected result, reported ... heads. ,"This is daydreaming at this point, but ... implanted light to stop seizures," says senior author Steven Mennerick, ...
... mothers' beliefs about diarrhea can lead to inappropriate treatment ... University undergraduate in Africa concluded the research. ... records – revealed that a “large proportion” of the ... a rudimentary understanding of how best to either prevent ...
... American Academy of Neurology finds that epidural steroid injections ... for lower back pain// that radiates down a leg, ... ,To develop the guideline, the authors analyzed scientific studies ... epidural steroid injections may provide some short-term pain relief ...
Cached Medicine News:Health News:Methylmercury in Marine Fish Pose Health Risks to Pregnant Women and Elderly Men 2Health News:Methylmercury in Marine Fish Pose Health Risks to Pregnant Women and Elderly Men 3Health News:A New Inexpensive Technology for Multiplexed Detection 2Health News:A New Inexpensive Technology for Multiplexed Detection 3Health News:Researchers Discover New Molecular Path to Fight Autoimmune Diseases 2Health News:Light-activated Compound May Be of Help for Epileptics in Future 2Health News:Light-activated Compound May Be of Help for Epileptics in Future 3Health News:Mothers in African Study Undereducated on Diarrhea 2Health News:Mothers in African Study Undereducated on Diarrhea 3
(Date:7/28/2014)... ORLANDO, Fla. , July 28, 2014 /PRNewswire/ ... "Company"), a biopharmaceutical company focused on the development, ... that it has filed definitive proxy materials with ... its 2014 Annual Meeting of Shareholders to be ... a.m., East Standard Time. The record date for ...
(Date:7/28/2014)... 2014 ResMed (NYSE: RMD ), ... cura dei disturbi respiratori del sonno (SDB) e altre ... in Germania contro il produttore Taiwanese di dispositivi medicali, ... apparecchiature da indossare in testa, che violano i brevetti, ... La sentenza della Corte Regionale Distrettuale di ...
(Date:7/28/2014)... (NYSE: RMD ), an innovator and pioneer ... and other chronic respiratory conditions, has won a permanent ... medical device manufacturer APEX Medical Corp. (APEX), prohibiting sales ... 220 masks.  The judgment was entered by the Regional ... appealable, and applies throughout Germany.  The ...
Breaking Medicine Technology:TNI BioTech, Inc., Files Definitive Proxy Materials; Mails Letter Urging Shareholders to Vote the Proxy Card 2TNI BioTech, Inc., Files Definitive Proxy Materials; Mails Letter Urging Shareholders to Vote the Proxy Card 3ResMed riceve un'ingiunzione permanente contro APEX in Germania, continua a far valere i propri diritti per i brevetti in Europa 2ResMed Receives Permanent Injunction against APEX in Germany, Continues Enforcement of Patents in Europe 2
Kleinert-Kutz Single Skin Hook, Large...
Medium....
Goldman single hook....
These products are supplied non-sterile and must be sterilized before use. For insertion through the smokevac and nezhat-dorsey trumpet valve in conjunction with the universal instrument insert adapt...
Medicine Products: