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Researchers exploit genetic 'co-dependence' to kill treatment-resistant tumor cells
Date:10/21/2009

at you can do this in human cells."

The discoveries of TBK1 and STK33 are only the first of what the scientists expect will be many more "co-dependent" genes in cancer cells that may prove valuable as drug targets.

"We plan to screen 300 cell lines over the next couple of years," said Hahn. "The aim is to create a dataset in which any investigator can say, 'I'm looking for genes that interact with this oncogene or that tumor-suppressor gene.' Our intent is to make these data public in order to help move the field forward."

In the meantime, Hahn said there is considerable interest in testing existing kinase inhibitors as potential new therapies for KRAS tumors. He added that researchers at Dana-Farber and the Broad are interested in developing novel molecular tools to suppress the action of co-dependent oncogene partners.


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Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

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