Navigation Links
Researchers exploit genetic 'co-dependence' to kill treatment-resistant tumor cells
Date:10/21/2009

K1 activity enables cancer cells to survive that otherwise would be destroyed by the body because they are abnormal and dangerous.

TBK1 is the second such gene co-dependent with KRAS to be discovered: In May, a team that included Barbie, Hahn, and other researchers reported in Cell that a kinase gene, STK33, had a similar function in KRAS tumors. Senior author of that report was D. Gary Gilliland, MD, PhD of Brigham and Women's Hospital, Dana-Farber, the Broad, and HMS.

The new approach exploits a relationship between the KRAS and TBK1 genes known as "synthetic lethality." The term refers to a partnership in which two genes (usually mutated) in a cell have a combined effect that neither has by itself. In some cases, neither mutation alone will kill a cell but the presence of both is lethal.

In the case of KRAS tumors, the opposite is true: both KRAS and TBK1 must be active for the cancer cell to survive; suppressing one or the other kills the cell.

The key role of TBK1 was identified in a large-scale search using the combined resources of Dana-Farber and the Broad Institute to hunt for genes that were essential exclusively to cells with mutant KRAS, but not to cells with wild-type (non-mutant) KRAS or other normal cells.

Working with scientists in the Broad's RNAi Platform, the team used RNA interference (RNAi) methods to turn off thousands of different genes in 20 laboratory cancer and non-cancer cells. They then sought out genes that, when shut down by short pieces of RNA strands, caused KRAS cells to self-destruct, but had no effect on normal cells. The screening process first identified 45 potential candidates, which were further winnowed in a secondary screen to single out TBK1.

"Until four or five years ago, you couldn't have contemplated doing an experiment like this on so large a scale," noted Hahn. "We now have the tools that make this possible." The new paper and its predecessor "really make it clear th
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Yerkes researchers present at 39th Annual Society for Neuroscience Conference
2. Patent challenges reduce pharmaceutical innovation and productivity, researchers suggest
3. ResearchToolkit.org provides one-stop Web resource for health researchers
4. New Professional Network Brings Chinese Scientists and Researchers into International Community
5. Pitt researchers find candidates for new HIV drugs
6. Researchers discover mechanism that helps humans see in bright and low light
7. New effort to battle antibiotic resistance rallies researchers throughout Harvard University
8. Researchers report benefits of new standard treatment study for rare pediatric brain cancer
9. Researchers identify genes associated with onset age of Parkinsons disease
10. BUSM researchers identify better laser for treating facial spider veins
11. Toronto researchers discover novel circulation in human eye, new glaucoma treatment target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2014)... July 26, 2014 The European security ... at $1290 million in 2014, and it is expected ... of 6.16%. The report incorporates the factors that influence ... of growth rates and projected total expenditure. The report ... global markets. Apart from the general overview of the ...
(Date:7/26/2014)... The North America Cyber Security report ... North America with analysis and forecast of revenue. This ... in 2014 to $33.24 billion by 2019, at a ... through the TOC of the North America Cyber Security ... analysis provided. It also provides a glimpse of the ...
(Date:7/26/2014)... (PRWEB) July 26, 2014 The European Artificial ... in Europe with analysis and forecast of revenue. The artificial ... $3.5 billion in 2013 to around $5.4 billion by 2018, ... , Browse through the TOC of European artificial lift market ... also provides a glimpse of the segmentation in European Artificial ...
(Date:7/26/2014)... 2014 The European gas chromatography reagents report ... and forecast of revenue. The gas chromatography reagents market in ... is estimated to grow to around $445.5 million by 2018, ... , Browse through the TOC of the European gas chromatography ... provided. This report also provides a glimpse of the segmentation ...
(Date:7/26/2014)... 26, 2014 Recently, iFitDress.com, a popular ... women, has unveiled its new range of high quality ... on the brand new items; they are now provided ... , iFitDress.com is one of the leading suppliers in ... all the wholesale party dresses have flattering ...
Breaking Medicine News(10 mins):Health News:Europe Security and Surveillance Radar Market is Expected to Reach $1800 million in 2019 - New Report by MicroMarket Monitor 2Health News:Europe Security and Surveillance Radar Market is Expected to Reach $1800 million in 2019 - New Report by MicroMarket Monitor 3Health News:Europe Security and Surveillance Radar Market is Expected to Reach $1800 million in 2019 - New Report by MicroMarket Monitor 4Health News:Europe Security and Surveillance Radar Market is Expected to Reach $1800 million in 2019 - New Report by MicroMarket Monitor 5Health News:North America Cyber Security Market is Expected to Reach $33 billion in 2019 - New Report by MicroMarket Monitor 2Health News:North America Cyber Security Market is Expected to Reach $33 billion in 2019 - New Report by MicroMarket Monitor 3Health News:North America Cyber Security Market is Expected to Reach $33 billion in 2019 - New Report by MicroMarket Monitor 4Health News:Europe Artificial Lift Services Market is Expected to Reach $5.4 Billion in 2018 - New Report by MicroMarket Monitor 2Health News:Europe Artificial Lift Services Market is Expected to Reach $5.4 Billion in 2018 - New Report by MicroMarket Monitor 3Health News:Europe Artificial Lift Services Market is Expected to Reach $5.4 Billion in 2018 - New Report by MicroMarket Monitor 4Health News:Europe Artificial Lift Services Market is Expected to Reach $5.4 Billion in 2018 - New Report by MicroMarket Monitor 5Health News:Europe Gas Chromatography Reagents Market is Expected to Reach $445.5 million in 2018 - New Report by MicroMarket Monitor 2Health News:Europe Gas Chromatography Reagents Market is Expected to Reach $445.5 million in 2018 - New Report by MicroMarket Monitor 3Health News:Europe Gas Chromatography Reagents Market is Expected to Reach $445.5 million in 2018 - New Report by MicroMarket Monitor 4Health News:Europe Gas Chromatography Reagents Market is Expected to Reach $445.5 million in 2018 - New Report by MicroMarket Monitor 5Health News:High Quality Wholesale Party Dresses Online at iFitDress.com 2
... to patients with a history of growths in their colon ... believe that most colorectal cancer develop out of polyps, or ... ,However, the latest research, conducted in France, Denmark, Italy ... to grow in patients given this fibre supplementation. In 456 ...
... researchers, a new treatment has been effective for inoperable liver cancer. It ... and it is showing a 25 ... per cent success rate in either reducing tumour size or the ... treatment with advanced liver tumours, who cannot be treated by any other ...
... people who suffer from dementia benefit from music therapy. The ... music. The trials have found that the therapy is popular ... ,scientists at Imperial College London are planning to carry out ... therapy has long term benefits for dementia sufferers. If their ...
... supplements given to babies with low birth weight can ... often die from infectious diseases. The research involved 1,154 ... Delhi, India, most weighing 5 1/2 pounds or less. ... nine months. Fifteen of the 20 who died had ...
... India (MSI), the sole franchisee for US based Medicine Shoppe ... has dropped Chennai from list of its target for operations ... drew up plans to expand its franchisee operations from the ... current financial year, has decided to put on hold the ...
... heavy breakfast and a steaming cup of tea may increase a ... fried food each morning are at twice the risk of the ... reduce the incidence of cancer is to begin the day with ... of the oesophagus - the food pipe connecting the stomach with ...
Cached Medicine News:Health News:Cut down on fries 2
(Date:7/25/2014)... 25, 2014  Corporate libraries are constantly being faced ... in technology and how to cope with flat or ... pharmaceutical and medical device industries are increasingly finding it ... services they provide. According to recent ... many forces of change that leading corporate libraries are ...
(Date:7/25/2014)... N.C. , July 25, 2014  In today,s ... is costly and challenging - as is managing a ... Is it possible - or even preferable ... If so, where can you combine resources and activities, ... These are just a few of ...
(Date:7/25/2014)... 25, 2014 /PRNewswire-iReach/ -- "Australia Capsule Endoscopy Systems Market ... Australia Capsule Endoscopy Systems market. The report provides value, ... average prices (in US dollars) within market segments: ... , Capsule Endoscopes , Capsule Endoscopy Data Recorders ... report also provides company shares and distribution shares data ...
Breaking Medicine Technology:Forces of Change Reshaping Corporate Libraries & Information Services 2Using Promotional Efficiency to Support Multiple Products and Indications in the Pharmaceutical Marketplace 2Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 2Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 3Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 4Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 5
... BEIJING, May 7, 2012 /PRNewswire-Asia-FirstCall/ -- China Biologic Products, Inc. ... leading plasma-based biopharmaceutical companies in the People,s Republic of China, ... covering its first quarter 2012 results on May 9, 2012 ... p.m. in China on the same day. Hosting ...
... S. Weinstock and G. Scott Vezina of ... obtained a $78.5 million verdict on behalf of a child ... negligence. The child, now 3 years old, has severe spastic ... of an emergency cesarean section delivery. The case was tried, ...
Cached Medicine Technology:China Biologic Products to Host Earnings Conference Call on May 9, 2012 at 8:00 a.m. EDT (NY) 2$78.5 Million Jury Verdict In Philadelphia Birth Injury Case 2$78.5 Million Jury Verdict In Philadelphia Birth Injury Case 3
... Solo microplate incubator is an extremely ... a single microplate up to 50C. ... applications requiring higher temperatures up to ... offering low cost and high performance ...
... The iEMS Incubator/Shaker HT is ... the iEMS Incubator/Shaker HT is ... DNA hybridization and primer extension ... available as a one-cabinet model, ...
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. -...
Minimal M9CA Broth...
Medicine Products: