Navigation Links
Researchers expand natural killer cells in cord blood to fight leukemia
Date:5/16/2008

CINCINNATI, OHIO - Researchers from The University of Texas M. D. Anderson Cancer Center have found a therapy that effectively kills human leukemia cells in mice using natural killer (NK) cells from umbilical cord blood.

Patrick Zweidler-McKay, M.D., Ph.D., assistant professor of pediatrics from the Children's Cancer Hospital at M. D. Anderson, has shown an effective method for expanding the number of NK cells from a single cord blood unit while retaining the cells' anti-leukemia effects, as presented at the American Society of Pediatric Hematology/Oncology annual conference on May 16.

Previous efforts to expand cord blood have resulted in ineffective NK cells. However, Zweidler-McKay and co-senior investigator Elizabeth Shpall, M.D., professor in M. D. Anderson's Department of Stem Cell Transplantation and Cellular Therapy, have found a novel process to increase NK cells in cord blood more than 30-fold, generating more than 150 million NK cells from one cord blood unit while maintaining their activation to find and kill acute leukemia cells.

When given to mice with aggressive human leukemias, these NK cells reduced the circulating human acute lymphocytic leukemia (ALL) and acute myelogenous leukemia (AML) cells by 60 to 85 percent.

"Cord blood is a promising source of natural killer cells because the NK cells have enhanced sensitivity to stimulation, decreased potential to cause graft-versus-host disease and are available from cord banks throughout the country and world," says Zweidler-McKay.

NK Cells Spare Normal Cells While Attacking ALL and AML

Graft-versus-host disease is a common side effect of patients receiving stem cell transplants, which results when the T cells in the transplanted blood react against the patient's own cells. This disease can become fatal if it's unable to be controlled. NK cells operate differently from T cells, leaving normal cells alone while targeting and killing the cancerous cells.

Historical transplants used a matched donor's peripheral blood or bone marrow to transplant to a patient. However, in 1988, researchers found cord blood to be another source for stem cell transplantation. These immature stem cells were easier to match to patients, especially those from non-Caucasian ethnicities, and could be stored for use as needed.

Zweidler-McKay's study involves selecting out NK cells from cord blood. As the cord blood is expanded to multiply in number, the NK cells are given a cytokine, interleukin-2, and a target cell, K562, which keep the NK cells active throughout the three week expansion.

Once the process is complete, the NK cells can be transplanted to patients without prior chemotherapy. Zweidler-McKay also predicts this type of transplant could be used for adults who have already had a transplant or for those adult and pediatric patients who aren't candidates for other stem cell transplants due to blood counts or illness.

"These NK cells demonstrate significant cytotoxic activity against human AML and ALL cell lines and patient leukemia blasts. Most importantly, mouse models of human AML and ALL were sensitive to NK cell infusions," says Zweidler-McKay. "These results support the evaluation of cord blood-derived NK cells as a potential immuno-therapeutic approach in acute leukemias."


'/>"/>

Contact: Sara Farris
sfarris@mdanderson.org
281-467-1337
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Related medicine news :

1. Medical College of Wisconsin researchers identify proteins that help develop mammalian hearts
2. Mastectomies on the rise and MRI use may explain part of the trend, say Mayo researchers
3. UCSD researchers show link between vitamin D status, breast cancer
4. Researchers find first conclusive evidence of Alzheimers-like brain tangles in nonhuman primates
5. Vancouver researchers discover missing link between TB bacteria and humans
6. 1 of the best researchers in general practice
7. Researchers fine-tune clot-busting treatment for bleeding in brain
8. OHSU Cancer Institute researchers pinpoint how smoking causes cancer
9. Yerkes researchers find link between psychological stress and overeating
10. Researchers who helped millions with arthritis receive prestigious Janssen Award
11. Carnegie Mellon engineering researchers automate analysis of protein patterns
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers expand natural killer cells in cord blood to fight leukemia
(Date:9/24/2017)... ... September 24, 2017 , ... “Star of Bethlehem Study”: is a thought-provoking ... the creation of published author, Duane Engdahl, an investigator who had has a long ... Duane Engdahl’s new book is a thought-provoking essay an event so significant that it ...
(Date:9/23/2017)... ... ... “You Can't Win Them All”: the story of an entrepreneur and a family man ... the lives of young athletes. “You Can't Win Them All” is the creation ... a small town in Northern Ontario, Canada. He is an entrepreneur who manages ...
(Date:9/22/2017)... ... September 22, 2017 , ... Fenwick Agency of Plano, TX ... they serve as part of the nationally recognized ‘Agents of Change’ movement. The agency ... organizations and community leaders to seek out those who most need help. Their hope ...
(Date:9/22/2017)... ... 2017 , ... SABRE is pleased to announce the ... a graduate student from Sonora, California, who will begin her studies this fall ... in Miami, Florida, was selected from a pool of more than 50,000 applicants ...
(Date:9/22/2017)... ... September 22, 2017 , ... TopConsumerReviews.com recently awarded their highest ... helps promote pancreatic health and regulate blood sugar levels . , Preventing ... have negative side effects, and with the changes in today’s healthcare industry, not ...
Breaking Medicine News(10 mins):
(Date:9/1/2017)... Sept. 1, 2017 Michael Penna , ... , highlights opportunities for growth in his response to ... Marlin Equity is seeking a buyer for eMDs. Penna,s ... 22-year-old healthcare solutions Value Added Reseller and national leader ... "As the healthcare market continues to ...
(Date:8/31/2017)... Aug. 31, 2017 PM360,s annual Innovations ... to the latest innovations happening across the industry. Established ... to focus on providing a comprehensive look at the ... covers the most innovative companies, startups, divisions, products, services, ... "Everyone in this industry wants to ...
(Date:8/28/2017)... Hill-Rom Holdings, Inc. (NYSE: HRC), will present at the Morgan ... New York . John Greisch , ... at 11:05 a.m. Eastern Time. The live ... recorded replay will be available one hour after the conclusion ... About Hill-Rom Holdings, Inc. ...
Breaking Medicine Technology: