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Researchers establish new rule to predict risk of stroke, death from surgery that prevents it
Date:12/10/2010

DALLAS Dec. 10, 2010 It's a medical Catch-22: carotid artery surgery can itself cause stroke, but so can asymptomatic carotid disease if left untreated.

UT Southwestern Medical Center researchers have now developed a clinical risk prediction rule using factors such as sex, race and health history to assess the danger the surgery poses, while a modified version will help patients make a more fully informed choice about whether to have the procedure.

"It may take a thief to catch a thief, but physicians don't want to cause stroke while trying to prevent stroke, so being able to carefully weigh an individual's benefits and risk from carotid surgery is critically important," said Dr. Ethan Halm, chief of the William T. and Gay Solomon Division of General Internal Medicine and senior author of the study published in the journal Stroke.

Researchers drew on factors that increase the risk for postsurgical death or stroke for people with silent, or asymptomatic, carotid disease to predict which patients were at highest risk for complications. Those most at risk were female, non-white and had certain neurologic and heart diseases.

The carotid arteries, which run on the sides of the neck, are main blood vessels that supply oxygen to the brain. These arteries can become narrowed by fatty cholesterol deposits called plaque. If pieces of plaque break free, they can lodge in the brain, causing stroke.

In carotid endarterectomy (CEA), one of the most common types of vascular surgery performed in the U.S., surgeons open the artery and remove the plaque. Silent, or symptom-free, carotid artery disease usually is found by chance during unrelated medical tests.

"Asymptomatic patients achieve only a modest benefit from surgery their chance of stroke decreases from 2 percent annually to 1 percent annually because they have a lower chance of having a stroke in the first place," Dr. Halm said. "For patients with sever
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Contact: LaKisha Ladson
lakisha.ladson@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

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