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Researchers discover why steroid treatment for COPD is ineffective
Date:10/18/2011

oraphane restored HDAC2 activity and corticosteroid sensitivity. Previous studies by the research team showed sulforaphane activates the Nrf2 pathway (nuclear factor erythroid 2related factor 2) and it is being tested in clinical trial for patients with COPD.

"Restoring corticosteroid sensitivity in patients with COPD by targeting the Nrf2 pathway holds promise for effectively treating exacerbations," said Shyam Biswal, PhD, senior author of the study and professor in the Bloomberg School's Department of Environmental Health Sciences and Division of Pulmonary and Critical Care Medicine at the Johns Hopkins School of Medicine.


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Contact: Tim Parsons
tmparson@jhsph.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health
Source:Eurekalert

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