Navigation Links
Researchers discover way to halt lung inflammation in animal models
Date:1/14/2011

AURORA, Colo. (Jan. 14, 2011) - Acute inflammation of the lung is a poorly recognized human disease that develops in surprising and unexpected ways. The acute lung injury (ALI) or adult respiratory distress syndrome (ARDS) is a vital new concern for soldiers, but it can develop in anyone during a systemic infection, after severe trauma, as a result of bone fracture, following severe burns and in many other ways as well-- the initial cause may have nothing apparent to do with the lung itself. However, an answer to halting lung inflammation may have been discovered, thanks to a University of Colorado School of Medicine researcher and his team.

Recent studies show that between 60,000 and 100,000 people die each year in the United States from ALI/ARDS, more than twice as many fatalities as those from breast cancer. Recognition that the disease represents an uncontrolled inflammation of the lung has led to some important developments for treatment but even today mortality hovers around 60 percent for those people in whom the disease was identified early enough to initiate treatment.

In a study titled Xanthine Oxidoreductase Promotes the Inflammatory State of Mononuclear Phagocytes through Effects on Chemokine Expression, Peroxisome Proliferator-activated Receptor-γ Sumoylation, and HIF-1α publishing today in The Journal of Biological Chemistry, researchers use animal models of ALI/ARDS to show that the aggressive inflammatory state of specific immune cells can be switched off to control the runaway inflammation.

"We now know that cells of the so called innate immune system, neutrophils and macrophages, are involved in causing lung injury that can result in lung failure and death," said Richard Wright, PhD, associate professor at the University of Colorado School of Medicine and lead study researcher. "While these cells are very important for our natural ability to fight off infection, the circumstances that lead to ALI/ARDS can overwhelm this beneficial role. Study of the neutrophils and macrophages that are responsible for ALI/ARDS has led to important ideas which offer hope for new concepts and options for treatment. For example, it is now known that the macrophage itself can exist in both an aggressive inflammatory state and in a more reparative state that can even help the lung to heal."

The researchers now have several drugs that work to achieve the same effect. Ideally, the researchers would like to see that by switching the state of the macrophages to the more reparative state, the ongoing inflammation will be stopped and the capacity of the lung to repair itself will improve.

"This could provide us with a vital new approach to treating this still devastating disease and reduce the persistent mortality of ALI/ARDS," said Wright.

"The results from this study clearly show how an essential enzyme involved in a vital metabolic pathway in our body can control the inflammatory state of key immune cells responsible for acute inflammatory diseases," said Mehdi Fini, MD, a research instructor at the University of Colorado School of Medicine and one of the authors of the paper. "The data from this study will also help us understand and dissect the molecular pathway involved in differential behavior of these cells in the pathogenesis of other diseases of the lung including chronic obstructive pulmonary disease (COPD), lung fibrosis and lung cancer."

Other University of Colorado School of Medicine researchers who collaborated on the study include Jenifer Monks, PhD, and Sean Colgan, PhD.


'/>"/>

Contact: Caitlin Jenney
caitlin.jenney@ucdenver.edu
303-315-6376
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. LA BioMed researchers among Americas Top Doctors
2. Researchers find rising levels of hypertension in older Mexican-Americans
3. Robotic surgery of tremendous benefit to patients, say JGH researchers
4. UBC-VCH researchers find critical link between Down syndrome and Alzheimers disease
5. UNC researchers investigate estrogen to prevent depression and cardiovascular disease
6. Feast or famine: Researchers identify leptin receptors sidekick as a target for appetite regulation
7. UNC researchers inch closer to unlocking potential of synthetic blood
8. Men with macho faces attractive to fertile women, researchers find
9. Researchers pinpoint origin of deadly brain tumor
10. Yale researchers find double doses of chicken pox vaccine most effective
11. FSU researchers helping electric-wheelchair users move more easily
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... Fort Collins, CO (PRWEB) , ... May 05, ... ... has announced the commencement of a master charity program created to assist the ... every 60 days, working closely with nonprofit organizations and community leaders. Their hope ...
(Date:5/5/2016)... ... May 05, 2016 , ... Tim Dieter has announced the ... greater Dubuque, IA. The current campaign fundraises for Veteran’s Freedom Center on behalf ... Veteran’s Freedom Center may now be made here: http://www.veteransfreedomcenter.com/donate/ . , Veteran’s ...
(Date:5/5/2016)... ... May 05, 2016 , ... TIME for Kids and The ... announced a new partnership to reach nearly 1 million children with important water safety ... and is the leading cause of accidental death in children one to 6 years ...
(Date:5/5/2016)... ... , ... The 2016 Nike Soccer Camp will be directed by the 2015 ... Together they bring their winning Vandals coaching philosophy to young athletes. Programs are offered ... high school players. Session dates are as follows: , Youth Day Camp – July ...
(Date:5/5/2016)... Toledo, Ohio (PRWEB) , ... May 05, 2016 , ... ... Revenue Cycle. , Clark brings more than 15 years of experience within the ... comes from a successful career as the Director of Patient Financial Services at Spectrum ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)...   BIOTRONIK will be exhibiting and initiating ... implant at the Heart Rhythm Society,s 37 th ... Francisco . "Physicians and hospitals ... patient care and satisfaction possible. Part of that process ... tomorrow," said Marlou Janssen , President, BIOTRONIK, Inc. ...
(Date:5/3/2016)... 3, 2016 Pharmaceutical giant Johnson ... to a woman who says its talc-based powder products ... Gloria Ristesund $5 million in compensatory damages and ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , This is ... company. In February, the same court awarded $72 million ...
(Date:5/3/2016)... 2016  Specialty Silicone Fabricators is offering teachers ... a cleanroom works. The free visual aid provides ... technology. Chris Mazelin , ... SSF enthusiastically supports the Science, Technology, Engineering and ... next generation of innovators. We want to provide ...
Breaking Medicine Technology: