Navigation Links
Researchers discover underlying mechanisms of skin hardening syndromes
Date:5/17/2011

(Boston) - Researchers from Boston University School of Medicine (BUSM) have discovered new details about the underlying mechanisms of skin hardening syndromes. The team connected pharmacological properties of the Novartis Pharma AG drug called balicatib to the skin disorder for the first time after investigating adverse reactions suffered by patients participating in a clinical trial for the treatment of osteoporosis. These findings appear online in the Journal of the American Academy of Dermatology.

Balicatib was developed recently as an osteoporosis drug that can inhibit CathepsinK (catK), an enzyme involved with bone degradation. In a recent trial however, several patients on balicatib experienced hardening of the skin, most frequently around the neck, chest and abdomen. After examining the cases and relating them to recent reports of cathepsin K expression in the skin and the role of cathepsin K in degrading collagen and elastin, the investigators determined that the changes were a direct effect of the drug.

This case study adds a new class of medication to the short list of agents that induce skin hardening syndromes. It also proves that catK affects the skin as well as bones, and marks the first time that skin hardening can be convincingly linked to the pharmacologic properties of a drug.

"This observation emphasizes the importance of intracellular collagen degradation in the skin, a pathway so far vastly underappreciated," said Thomas Ruenger, MD, PhD, a professor and vice-chair of dermatology at BUSM. "This observation also sheds new light on our understanding of the mechanisms involved in morphea, or skin hardening. Failed collagen degradation has so far not been thought to cause morphea."

The researchers believe these findings have far-reaching implications for osteoporosis patients and those suffering from skin hardening syndromes.


'/>"/>

Contact: Nathan Bliss
nathan.bliss@bmc.org
617-638-8490
Boston University Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... ... ... full swing, Americans are flocking to Canada’s many lakes to reel in their fair share ... and it’s easy to understand why. From the Pacific Northwest Coast of British Columbia to ... a huge industry, and Americans make up the vast majority of anglers from outside of ...
(Date:7/2/2015)... ... ... LIFX ” was featured on NewsWatch as part of its monthly Tech Report, which ... expert and special reporter for NewsWatch, conducted the review and shared with viewers how ... According to the U.S. Department of Energy, it’s very important to use energy-efficient light ...
(Date:7/2/2015)... ... July 02, 2015 , ... Get ready ... SIGVARIS PERFORMANCE SOCKS. Since the socks were first introduced, they have rapidly been ... popularity has inspired four new, fun shades including: blue, lime, pink and red. ...
(Date:7/2/2015)... Md. (PRWEB) , ... July 02, 2015 , ... Six ... in his solo cross-country walk to raise awareness and money for the Pulmonary ... expects to arrive at PHA’s headquarters near Washington, D.C. by mid-September. He left Glasgow, ...
(Date:7/2/2015)... Diego, CA (PRWEB) , ... July 02, 2015 , ... ... and a passion for social fitness. Built to function as a lifestyle community, Active ... giving them the opportunity to network, meet, and participate in discussions or group events. ...
Breaking Medicine News(10 mins):Health News:The Most Versatile Smart Light Bulbs were featured on NewsWatch Television 2Health News:SIGVARIS is Sporting Four Brand New Colors in the Popular PERFORMANCE SOCK Product Line 2Health News:79-Year-old ‘Pacing Parson’ Passes 1,000-Mile Mark in Cross-Country Walk for Pulmonary Hypertension Association 2Health News:79-Year-old ‘Pacing Parson’ Passes 1,000-Mile Mark in Cross-Country Walk for Pulmonary Hypertension Association 3Health News:ActiveBunch.com Launches as a Social Community for People with Active Lifestyles 2
... , Every year, millions of Americans ... about it. , The causes of ... overuse or trauma. Whatever the cause though, see a doctor ... are on,the same page. It,s all about communication. Write down ...
... Founder and President of Leventhal Consulting, www.leventhalconsulting.net , ... service for attorneys by an attorney, will be addressing ... today at Hellriegel,s Inn, 1840 Mentor Avenue, Painesville, Ohio, ... and works with clients over the telephone, through e-mail, ...
... manage perception of price and price itself Kurt Salmon ... are spending an estimated 3% less on ... part, to the economic downturn, according to Kurt Salmon ... decline is likely the result of a continued shift ...
... published in the Journal of the American Academy ... with low back pain to consider physical therapy as ... to the American Physical Therapy Association (APTA). The review, ... of symptomatic lumbar degenerative disc disease, a common cause ...
... Federico, M.D., president and CEO of Lakeside ... an affiliation between Lakeside Community Healthcare Network ... Verdugo Hills Medical Group IPA, both Glendale-based ... Hills Medical Group IPA brings more than ...
... (PHILADELPHIA) Two-thirds of patients referred for psychiatric services ... only an answering machine when they call for help, ... clinics with physical symptoms. Only 10 percent of all ... resulted in an appointment scheduled within two weeks, according ...
Cached Medicine News:Health News:MultiVu Video Feed: Save Your Knees! Treatments Are Available! 2Health News:Mark Leventhal to Address the Lake County (OH) Bar Association 2Health News:Consumers Spending Less on Prescription Drugs 2Health News:Physical therapy is effective for management of low-back pain 2Health News:Lakeside Community Healthcare Continues Growth With Verdugo Hills Medical Group IPA Affiliation 2Health News:For psychiatric services, wait for the beep 2Health News:For psychiatric services, wait for the beep 3
(Date:7/2/2015)... , July 2, 2015 /PRNewswire/ - ESSA Pharma Inc. ... common shares have been approved for listing and trading on ... ESSA will begin trading on NASDAQ on July 9, ... Venture Exchange under the symbol "EPI". As a ... NASDAQ, each of the Company,s outstanding special warrants issued on ...
(Date:7/2/2015)... Fla. , July 2, 2015  Fort ... is pleased to announce that its Consumer Group ... Beverages") to Kerry Group plc (ISE: KRZ) ("Kerry"), ... taste and nutrition systems, as well as functional ... and pharmaceutical markets. Farlie Turner served as the ...
(Date:7/2/2015)... , July 2, 2015 Roche,s ... conspicuously high-growth market segment in hematology testing, according ... said that Roche,s recent unveiling of its Bloodhound digital ... cobas m 511 hematology analyzer – ... capture growth enjoyed by current leader CellaVision, but ...
Breaking Medicine Technology:ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 2ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 3ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 4Farlie Turner's Consumer Group Completes Sale of Insight Beverages to Kerry 2Kalorama: With Bloodhound, Roche Closes in on High-Growth Hematology Segment 2Kalorama: With Bloodhound, Roche Closes in on High-Growth Hematology Segment 3
... Vantage Health (OTC:BB – ticker symbol VNTH), (the ... (the "tender", "tenders") have been accepted by Tanzania,s Medical ... Salaam. The tenders will not be adjudicated, and the ... in this respect, until December 02, 2011. The Company ...
... Inc. (NYSE AMEX: ULU ), a ... portfolio of wound management and oral care products, today ... with Ironridge Global BioPharma and its affiliates ("Ironridge"), under ... certain conditions, to purchase common and preferred stock totalling ...
Cached Medicine Technology:Vantage Health Submits Tender Documents for Tanzania Medical Stores Department and University of Dar es Salaam Procurement Tenders 2Vantage Health Submits Tender Documents for Tanzania Medical Stores Department and University of Dar es Salaam Procurement Tenders 3ULURU Inc. Enters Into Strategic Financings of Up to $1.6 Million at a Premium to Current Share Price 2ULURU Inc. Enters Into Strategic Financings of Up to $1.6 Million at a Premium to Current Share Price 3
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
Smooth, rounded working end manipulates organs less traumatically. Used as a general manipulative instrument....
Medicine Products: