Navigation Links
Researchers discover that the body clock may influence morning peak in adverse cardiovascular events
Date:11/11/2013

Boston Cardiovascular disease is the number one cause of death in both men and women, and most adverse cardiovascular events tend to happen in the morning. In new findings published in the November issue of Blood, researchers from Brigham and Women's Hospital (BWH) and Oregon Health & Science University have discovered that the internal body clock may contribute to the morning peak in heart attacks and ischemic strokes.

"Our findings suggest that the circadian system, or the internal body clock, contributes to the increased risk for cardiovascular events in the morning," said Frank A.J.L. Scheer, PhD, director of the Medical Chronobiology Program at BWH and corresponding author of this study.

The researchers studied 12 healthy adult volunteers in the intensive physiological monitoring laboratories at BWH. Participants were assessed throughout a two-week laboratory protocol designed to desynchronize daily behavioral and environmental rhythms from internal circadian rhythms.

Researchers specifically evaluated the role of Plasminogen activator inhibitor-1 (PAI-1), which inhibits the breakdown of blood clots and is thus a risk factor for blood clotting, one of the major contributors to heart attack and ischemic stroke. The researchers sought out to test whether this morning peak in PAI-1 is caused by the internal circadian system or by behaviors that typically occur in the morning, such as altered posture and physical activity. The researchers found a robust circadian rhythm in circulating PAI-1 with a peak corresponding to approximately 6:30 a.m. in a regular sleep/wake cycle.

"Our findings indicate that the human circadian system causes a morning peak in circulating levels of PAI-1, independent of any behavioral or environmental influences," explained Steven Shea, PhD, director of the Oregon Institute of Occupational Health Sciences and the co-author of this paper. "Indeed, the circadian system determined to a larg
'/>"/>

Contact: Jessica Maki
jmaki3@partners.org
617-525-6373
Brigham and Women's Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015 The Incredible Bulk is a revolutionary ... increase lean muscle by up to 30lbs in less than ... of HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , “Our ... step-by-step, scientific diet formula that allows the body to pack ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David ... Show to bestow a Juvent Sports Achievement award upon ... McKitrick. The award commemorated and congratulated McKitrick for her ... won her first amateur tournament in 1979 and most ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Carinsurancesavings.biz has released ... accidental death and dismemberment insurance . , Purchasing an ... can be very advantageous. This type of rider provides benefits ... dismemberment can be considered a lesser form of life insurance. ...
(Date:1/22/2015)... IsoComforter, Inc. has introduced the most innovative ... design to treat specific body parts and muscle groups. , ... easy to use patented cold therapy machine with the innovative ... and muscle injuries. IsoComforter has become the industry leader ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 JJsHouse.com is a ... dresses. Today, the business announces its latest collection of ... , “The most important issue is the wedding dress on ... thing in a woman’s life. Every bride wants to find ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2
... Alan Mozes HealthDay Reporter , MONDAY, Sept. 19 ... common, non-infectious diseases -- cancer, diabetes, heart disease, lung disease ... million in treatment costs and lost wages. ... Burden of Non-communicable Diseases," released by the World Economic Forum ...
... pioneered a new combination treatment for prostate cancer. The ... will now be tested for efficacy in a second phase. ... and aggressive form of prostate cancer which has spread to ... developed. It combines traditional chemotherapy treatments with two doses ...
... Massachusetts health care reform designed to bolster employer-based insurance ... unable to afford it, the uninsured in Massachusetts remain ... by researchers at Harvard Medical School just published online ... The 2006 comprehensive health care reform was designed ...
... 17 (HealthDay News) -- ,Paralyzed veterans who learned to ... new study suggests. Researchers brought 10 paralyzed veterans ... May for a four-day scuba certification course. Before ... psychological tests, measuring muscle spasticity, motor control and sensitivity ...
... 16 (HealthDay News) -- People who carry a certain ... a lower five-year survival rate after coronary artery bypass ... to better treat and ensure the survival of these ... from Duke University Medical Center in Durham, N.C. ...
... September 16, 2011 Researchers have shown for the first ... by binding to and rendering inert protein p53, a known ... Texas Medical Branch may lead to treatments for a range ... appears in the current print issue of the Journal ...
Cached Medicine News:Health News:Global Toll of 'Non-Communicable Diseases' -- $47 Trillion by 2030 2Health News:Global Toll of 'Non-Communicable Diseases' -- $47 Trillion by 2030 3Health News:Global Toll of 'Non-Communicable Diseases' -- $47 Trillion by 2030 4Health News:Queen's pioneers prostate cancer breakthrough 2Health News:Uninsured patients in Mass. still mainly the working poor, despite state's health reform 2Health News:Uninsured patients in Mass. still mainly the working poor, despite state's health reform 3Health News:Scuba Diving May Help Paralyzed Vets 2Health News:Gene Variant May Raise Death Risk After Heart Bypass 2Health News:Researchers identify potential molecular target to prevent growth of cancer cells 2
(Date:1/23/2015)...  Today the U.S. Food and Drug Administration (FDA) announced ... serogroup B meningococcal disease in individuals ages ... received FDA approval in October, represent a significant step ... "I have heard over and over from parents ...
(Date:1/23/2015)... 2015 A lot of discussion in the medical community ... illnesses, injuries, or conditions. As medical science advances, doctors and ... ones that they consider to be more cutting edge. Yet, ... textbook method of treatment that stands out as the best ...
(Date:1/23/2015)... to Fight Chronic Disease (PFCD) released a public opinion poll of ... study analyzing the impact of increased cost sharing on patient adherence ... educate policy makers and the public on the costs of chronic ... the Iowa healthcare exchange could be improved ...
Breaking Medicine Technology:The National Meningitis Association (NMA) Applauds FDA Approval of Second Vaccine To Protect Against Serogroup B Meningococcal Disease 2No One-Size-Fits-All Remedy for Hernia Correction 2New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3
... , STAMFORD, Conn. , Feb. ... treatment will soon have advanced technology available to the medical ... FUJIFILM Medical Systems USA (Fujifilm), and AmeriCares, a portable digital ... and will be sent to a hospital where currently x-ray ...
... , , SINGAPORE , UPPSALA, Sweden ... Novus Scientific Pte. Ltd today announced that the US Food and ... the TIGR™ Matrix Surgical Mesh, for use in reinforcement ... Mesh is a 100 percent resorbable, synthetic matrix, knitted from two ...
Cached Medicine Technology:Local Organizations Partner to Improve Healthcare in Haiti 2Local Organizations Partner to Improve Healthcare in Haiti 3Local Organizations Partner to Improve Healthcare in Haiti 4Local Organizations Partner to Improve Healthcare in Haiti 5Novus Scientific Receives FDA Clearance for TIGR(TM) Matrix Surgical Mesh - World's 1st Long-Term Resorbable Synthetic Mesh 2Novus Scientific Receives FDA Clearance for TIGR(TM) Matrix Surgical Mesh - World's 1st Long-Term Resorbable Synthetic Mesh 3
... Artis FC is a floor-mounted, ... flexible system architecture for vascular ... The flexible and ergonomic system ... adapt the system configuration to ...
The ACUSON Sequoia C512 system elevates imaging and Doppler performance through new, high-density acoustic sampling, precise control of the transmitted acoustic waveform, and new transducer technolog...
... cardioangiography procedures with MR imaging results and ... Utilize your angio and MR system at ... suite. Because the systems can be combined ... follow-up in one room, one control room ...
... every beating heart at any heart rate and ... scanner using two X-ray sources and two detectors ... in acute care; even with large patients, regardless ... Cardiac Engine, a unique combination of Siemens innovative ...
Medicine Products: