Navigation Links
Researchers discover that the body clock may influence morning peak in adverse cardiovascular events
Date:11/11/2013

Boston Cardiovascular disease is the number one cause of death in both men and women, and most adverse cardiovascular events tend to happen in the morning. In new findings published in the November issue of Blood, researchers from Brigham and Women's Hospital (BWH) and Oregon Health & Science University have discovered that the internal body clock may contribute to the morning peak in heart attacks and ischemic strokes.

"Our findings suggest that the circadian system, or the internal body clock, contributes to the increased risk for cardiovascular events in the morning," said Frank A.J.L. Scheer, PhD, director of the Medical Chronobiology Program at BWH and corresponding author of this study.

The researchers studied 12 healthy adult volunteers in the intensive physiological monitoring laboratories at BWH. Participants were assessed throughout a two-week laboratory protocol designed to desynchronize daily behavioral and environmental rhythms from internal circadian rhythms.

Researchers specifically evaluated the role of Plasminogen activator inhibitor-1 (PAI-1), which inhibits the breakdown of blood clots and is thus a risk factor for blood clotting, one of the major contributors to heart attack and ischemic stroke. The researchers sought out to test whether this morning peak in PAI-1 is caused by the internal circadian system or by behaviors that typically occur in the morning, such as altered posture and physical activity. The researchers found a robust circadian rhythm in circulating PAI-1 with a peak corresponding to approximately 6:30 a.m. in a regular sleep/wake cycle.

"Our findings indicate that the human circadian system causes a morning peak in circulating levels of PAI-1, independent of any behavioral or environmental influences," explained Steven Shea, PhD, director of the Oregon Institute of Occupational Health Sciences and the co-author of this paper. "Indeed, the circadian system determined to a large extent the PAI-1 rhythm observed during a regular sleep/wake cycle. This morning peak in PAI-1 could help explain adverse cardiovascular events in vulnerable individuals."

The researchers added that these studies established the circadian control of PAI-1 in healthy individuals and that future research is required to test whether this rhythm is amplified, blunted or shifted in vulnerable individuals, such as with obesity, diabetes, or cardiovascular disease.


'/>"/>

Contact: Jessica Maki
jmaki3@partners.org
617-525-6373
Brigham and Women's Hospital
Source:Eurekalert

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... (PRWEB) , ... March 27, 2017 , ... ... industry. Conventional sodium testing methods are complicated and require expert user knowledge. In ... new analytical method dedicated to the simplified, yet highly accurate, determination of sodium. ...
(Date:3/27/2017)... , ... March 27, 2017 , ... ... GTEC Orange facility from 8:00am-10:00am on Monday, April 3rd to commemorate the two-year ... be an opportunity for area-residents to celebrate two great years while also familiarizing ...
(Date:3/27/2017)... Texas (PRWEB) , ... March 27, 2017 , ... Harris ... hard of hearing, is bringing its latest products to the Deaf Seniors of America ... will have the opportunity to meet with knowledgeable ASL friendly staff from Harris Communications ...
(Date:3/25/2017)... ... 25, 2017 , ... Norland at Swissray is pleased to announce the release of ... The ELITE DXA has an active scan window, which is more than double that of ... the scan area could not undergo an accurate total body bone density or body composition ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... which will spark a conversation on the current obstacles facing infection prevention and ... completely preventable deaths caused by these infections. , The print component of ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... , March 27, 2017 ... to reach USD 16.0 billion by 2025, according to ... growing prevalence of chronic diseases is anticipated to be ... analyzers, which thereby widens the scope for growth during ... and bariatric population, which is highly susceptible to chronic ...
(Date:3/27/2017)... 2017  Impax Laboratories, Inc. (NASDAQ: IPXL)today announced that ... Bisaro as Impax,s President and Chief Executive Officer ... 27, 2017. Mr. Bisaro will succeed J. Kevin ... Chief Executive Officer since December of 2016. ... experience, Mr. Bisaro, 56, is an accomplished global business ...
(Date:3/27/2017)... -- Invivotek, LLC, a Genesis Biotechnology Group ® ... contract research organization (CRO), announced the completion of the ... research facility in Hamilton, New Jersey ... source to reduce costs and lessen the CRO facility,s ... Farm follows Invivotek,s recent expansion from a 19,712 square ...
Breaking Medicine Technology: