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Researchers discover strategy for predicting the immunity of vaccines
Date:11/23/2008

In the first study of its kind, researchers at the Yerkes National Primate Research Center and Emory Vaccine Center, Emory University, have developed a multidisciplinary approach involving immunology, genomics and bioinformatics to predict the immunity of a vaccine without exposing individuals to infection. This approach addresses a long-standing challenge in the development of vaccines--that of only being able to determine immunity or effectiveness long after vaccination and, often, only after being exposed to infection.

The study, which used the yellow fever vaccine (YF-17D) as a model, is available in the online edition of Nature Immunology and represents a long awaited step forward in vaccine immunology and predictive health.

YF-17D is one of the most successful vaccines ever developed and has been administered to nearly half a billion people over the last 70 years.

"A single shot of the vaccine induces immunity in many people for nearly 30 years," says Bali Pulendran, PhD, lead Yerkes researcher of the study and professor in the Department of Pathology and Laboratory Medicine at Emory University School of Medicine. "Despite the great success of the yellow fever vaccine, little has been known about the immunological mechanisms that make it effective," he continues.

Pulendran's team, including graduate student Troy Querec, PhD, in collaboration with Rafi Ahmed, PhD, director of the Emory Vaccine Center, Eva Lee, PhD, Georgia Institute of Technology, and Alan Aderem, PhD, Institute for Systems Biology in Seattle, sought to determine what makes such a vaccine effective so researchers can design new vaccines against global pandemics and emerging infections that repeat the success of this model vaccine.

The researchers used YF-17D to predict the body's ability shortly after immunization to stimulate a strong and enduring immunity. Researchers vaccinated 15 healthy individuals with YF-17D and studied the T c
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Contact: Emily Rios
erios@emory.edu
404-727-7732
Emory University
Source:Eurekalert

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