Navigation Links
Researchers discover rare leukemia-causing protein
Date:7/2/2012

CINCINNATIResearchers at the University of Cincinnati (UC) Hoxworth Blood Center have discovered a new gene target for leukemia therapy.

These findings, slated for the July 26, 2012 print issue of Blood, the journal of the American Society of Hematology, could lead to cellular targets for a patient population that otherwise may not have desirable outcomes and could potentially stop the onset of leukemia before it begins.

A team led by Jose Cancelas, MD, PhD, an associate professor of pediatrics at the UC College of Medicine and director of the research division at Hoxworth Blood Center, found that by inhibiting in animal models the protein Vav3, which controls cell signaling, the development of this leukemiaknown as BCR-ABL lymphoid leukemiais delayed.

"Despite advances in the treatment of this disease, the outcome of patients with this type of leukemia is very poor because it develops resistance to standard therapies," he says. "We found that the genetic deficiency of Vav3 delays the formation of leukemia by impairing the signals from BCR-ABL and the overproduction of leukemic cells. In doing this, it also allows the standardized therapies, or BCR-ABL inhibitors, to work."

Cancelas says this finding could lead to new multi-targeted therapies where Vav3 activity is related to the formation of leukemia.

"In collaboration with Dr. Nicolas Nassar, associate professor of pediatrics at UC and a physician in the division of experimental hematology at Cincinnati Children's Hospital Medical Center, we are now trying to find chemicals with Vav3 inhibitory activity," he says. "With this knowledge, we may be able to develop a therapy that can greatly improve the lives of patients facing leukemia."


'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers block pathway to cancer cell replication
2. Moffitt researchers find cutaneous human papillomavirus infection a risk factor for skin cancer
3. Researchers find abuse during childhood may contribute to obesity in adulthood
4. Viewing terrorist attacks on TV increases pain intensity -- Ben-Gurion U. researchers
5. Taking the fate of stem cells in hand: RUB researchers generate immature nerve cells
6. Moffitt Cancer Center researchers test drug combinations to prevent graft vs. host disease
7. 2 new vitamin D blood tests are often highly inaccurate, researchers say
8. To tackle health cares thorniest problems, 400 health researchers form new U-M-based institute
9. Moffitt researchers: Darwins principles say cancer will always evolve to resist treatment
10. Controversial vaccine trial should never have been run in India, researchers say
11. Researchers create the first GPS for the blind
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2017)... ... May 22, 2017 , ... ... on Wellocity to empower WeightZone Factor members to track their exercise patterns, monitor ... excellent health education, all on their mobile phones. It also provides social networks ...
(Date:5/21/2017)... ... 2017 , ... Chris Cornell, 52, was found dead on the night of Wednesday, May 17, ... lead singers in the rock industry would take his own life, but the extremely talented ... mental illness played a role in the death of Chris Cornell . , Depression ...
(Date:5/21/2017)... , ... May 20, 2017 , ... ... systems between ABC Financial Services and financial systems. , Dozens of ... exported files that are electronically processed through GetLinked into their club’s accounting system ...
(Date:5/21/2017)... ... May 20, 2017 , ... Pot. Reefer. Grass. Mary Jane. No matter what ... its attributes like never before. More than a map, new social marketplace Weedable ... strains, products – and for the first time – each other. A social marketplace ...
(Date:5/21/2017)... ... May 21, 2017 , ... Florida Pain Relief Group, a division of Physician ... at 109 Silver Palm Ave., Melbourne, on Monday, May 22. Initially the clinic will ... the Melbourne practice, PPOA operates 23 pain management clinics in Florida and the Dallas-Fort ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)...  The Corporate Whistleblower Center says, "We are ... clinics to call us anytime at 866-714-6466 if they ... in a substantial scheme to overbill Medicare. We ... employee of a medical equipment company if their ... medical practice groups with extra generous incentives to use, ...
(Date:5/9/2017)... , May 9, 2017  Oramed Pharmaceuticals Inc. ... a clinical-stage pharmaceutical company focused on the development ... the Canadian Intellectual Property Office has granted Oramed ... Administration of Exenatide". The patent covers Oramed,s invention ... GLP-1 is an incretin hormone that stimulates ...
(Date:5/6/2017)... , May 5, 2017  May is Stroke Awareness ... of the most important methods to prevent a stroke: ... Centers for Disease Control and Prevention, undetected and uncontrolled ... Omron, the global leader in personal heart health ... elimination of heart attack and stroke and is advancing ...
Breaking Medicine Technology: