Navigation Links
Researchers discover protein that may represent new target for treating type 1 diabetes
Date:1/4/2012

WINSTON-SALEM, N.C. -- Researchers at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine and colleagues have discovered a new protein that may play a critical role in how the human body regulates blood sugar levels. Reporting in the current issue of Pancreas, the research team says the protein may represent a new target for treating type 1 diabetes.

"This data may change the current thinking about what causes type 1 diabetes," said Bryon E. Petersen, Ph.D., professor of regenerative medicine and senior author. "Much more research is needed to understand exactly how the protein functions, but its discovery opens a new door to better understand and hopefully develop new treatments for this currently incurable disease."

The protein, which the scientists have named Islet Homeostasis Protein (IHoP), has so far been isolated in the pancreas of both humans and rodents. It is located in the pancreatic islets, clusters of cells that secrete the hormones insulin and glucagon that work together to regulate blood sugar. In healthy individuals, glucagon raises blood sugar levels and insulin helps lower gluocose levels by moving sugar from the blood into the body's cells. In people with type 1 diabetes, which affects about 5 percent of people with diabetes, the pancreas does not produce enough insulin and blood sugar levels are too high.

The researchers determined that IHoP is found within the glucagon-producing cells of the islets. In both humans and mice that haven't yet developed diabetes, the researchers found high levels of IHoP. But after the onset of diabetes, there was no expression of IHoP, suggesting that the protein may work to regulate blood sugar levels by regulating the balance between insulin and glucagon.

When the researchers inhibited production of the protein in rodents, there was loss of glucagon expression, which caused a chain of events that led to decreased insulin, increased levels of glucagon and death of insulin-producing cells.

"In a nutshell," said lead author Seh-Hoon Oh, Ph.D., "IHoP appears to keep blood sugar regulation in check. When IHoP isn't present, it throws the pancreas into a critical state and starts the process that results in type 1 diabetes." Oh is an instructor of regenerative medicine at Wake Forest Baptist.

It is currently believed that type 1 diabetes is caused by a viral or environmental trigger in genetically susceptible people that results in the body's white cells mistakenly attacking the insulin producing cells. Within 10 to 15 years of diagnosis, the insulin-producing cells are completely destroyed.

The current research supports the idea that cell death plays a role in type 1 diabetes, but the results suggest that IHoP may influence the process. Next steps in the research will be to explore how IHoP controls the interaction of insulin and glucagon.


'/>"/>
Contact: Karen Richardson
krchrdsn@wakehealth.edu
336-716-4453
Wake Forest Baptist Medical Center
Source:Eurekalert

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 27, 2016 , ... TherapySites, the leading website ... Tennessee Counseling Association. This new relationship allows TherapySites to continue to ... adding exclusive benefits and promotional offers. , "TCA is extremely excited about this ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever ... Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation ... as home to some of the world’s leading providers of cereal and other breakfast ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts ... applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention ... health care topics including advance care planning, healthcare costs and patient and family ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... To deal with these feelings, many turn to unhealthy avenues, such as drug or ... Center of Marne, Michigan, has released tools for healthy coping following a traumatic event. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
(Date:6/24/2016)... CLEMENTE, Calif. , June 24, 2016  American Respiratory Labs ... company, is now able to perform sophisticated lung assessments in patients, ... Technologies , Inc. Patients are no longer limited ... ndd,s EasyOne PRO ® , ARL patients like Jeanne R. of ... done in the comfort of her own home. ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
Breaking Medicine Technology: