Navigation Links
Researchers discover promising prognostic marker for aggressive breast cancer
Date:1/23/2013

Cleveland - A team of researchers led by Goutham Narla, MD, PhD, at Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, and collaborators at the Mount Sinai School of Medicine and Erasmus Medical Center, have discovered a gene variant that drives the spread of breast cancer. Published in Science Translational Medicine (embargoed Jan. 23 at 2:00 pm ET), the study lays the early foundation for predicting which breast cancer patients may develop more aggressive disease and for designing more effective treatments.

"Breast cancer is a genetically complex disease and it remains a challenge to predict disease outcomes and which patients may benefit from more aggressive treatment," says Dr. Narla, assistant professor at Case Western Reserve University School of Medicine and medical geneticist at UH Case Medical Center Seidman Cancer Center. "Our research has uncovered a promising gene marker that will not only help us better identify tumors that behave badly but provide a basis for developing and 'personalizing' therapies to better treat our patients."

The research team discovered that a mutant gene, KLF6-SV1, was linked to the recurrence and metastasis in women with breast cancer. The incorrect splicing of the KLF6 gene essentially creates a protein that causes cancer cells to spread or metastasize. The researchers examined the tumors of 671 breast cancer patients in a tumor bank at Erasmus University Medical Center (Rotterdam, The Netherlands) and found that those whose tumors expressed high levels of the gene variant were 50 percent more likely to die. Since recurrence and metastasis are the major causes of death in breast cancer, this finding will provide a new direction of research to both identify women at risk and to develop targeted drugs that block the process of metastasis.

"This study presents biological proof that this splice variant can potentially be a marker for determining which early
'/>"/>

Contact: Alicia Reale
alicia.reale@uhhospitals.org
University Hospitals Case Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers design a new imaging technique for identifying the age and sex of a corpse
2. Researchers map emotional intelligence in the brain
3. Researchers find that simple blood test can help identify trauma patients at greatest risk of death
4. Mayo Clinic researchers identify enzyme involved in deadly brain tumors
5. UNC researchers use luminescent mice to track cancer and aging in real-time
6. Gothenburg researchers make world top 10
7. Autism Researchers Surprised by Impaired Brain Connections
8. Researchers identify ways to improve quality of care measurement from electronic health records
9. Researchers identify genetic mutation for rare cancer
10. Researchers Link 25 New Gene Variants to Autism
11. Fox Chase researchers discover novel role of the NEDD9 gene in early stages of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Project Veritas is releasing a video ... MIT economist and Obamacare architect Jonathan Gruber to public ... the interview, which is being distributed on YouTube. , ... mislabeling in the Affordable Care Act in order to ... billion dollar per year tax grab. , “President Obama ...
(Date:12/17/2014)... -- Greater participation in music classes may benefit children,s ... kids in the nonprofit Harmony Project, which provides music ... Over two years, children who actively participated in ... processes speech and reading, compared to those with lower ... participation in music classes occurred in the same areas ...
(Date:12/15/2014)... Cancer researchers have just published an important new report ... pleural mesothelioma. Surviving Mesothelioma has just posted an article ... to read it now. , Doctors at Harvard, ... York’s Langone Medical Center performed complete genetic analyses on ... effort to pinpoint the genes that are most likely ...
(Date:12/15/2014)... 15, 2014 OutMarket , a ... “ Social Media Cheat Sheets ,” a guide that ... drives results on the top ten social media networks. ... helps drive awareness, engagement, and customer service. It can ... make an impact on new networks and weather constantly ...
(Date:12/15/2014)... Kathy McAfee, America's Marketing Motivator, was ... in the category of Best Blog 2014. McAfee received ... weekly career blog Networking Ahead which combines ... elevate their talent and influence through better networking, leadership ... book Networking Ahead for Business, has been motivating readers ...
Breaking Medicine News(10 mins):Health News:Project Veritas: James O’Keefe Interviews the Man Who Discovered Jonathan Gruber Videos 2Health News:Music Classes Boost Language Skills, Study Says 2Health News:New Study Reveals Genetic Mutations That May Trigger Mesothelioma, According to Surviving Mesothelioma 2Health News:OutMarket Releases Cheat Sheets for Social Media Marketing 2Health News:OutMarket Releases Cheat Sheets for Social Media Marketing 3Health News:Kathy McAfee, America’s Marketing Motivator, Wins Best Blog from Women World Awards 2
... a new business to battle the rising costs of making funeral arrangements ... in these difficult economic times, for families to try to cut costs ... ... -- Grief Counseling Services (GCS), located in New York, recently announced the ...
... launch of new professional massage therapy marketing tool and search directory ... ... Atlanta, GA (PRWEB) February 18, 2009 -- This new membership based ... therapists in their city and post their profiles to promote their ...
... With sexual activity among adolescents in the United ... and reports of up to 25 percent of all ... researchers and public health officials are looking for those ... an article published in the April 2009 issue of ...
... provide trauma relief ,to both sides of the conflict ... team plans a training of health and mental health ... its kind working in both Israel and Gaza. ... for Mind-Body Medicine,s groundbreaking model which teaches self-care techniques ...
... Feb. 23 Campaign for America,s Future co-director ... Mishel and Center for Economic and Policy Research ... statement after participating in President Obama ,s summit ... ROGER HICKEY, DEAN BAKER AND LAWRENCE ...
... non-profit LENA(TM) Foundation, which develops technology for the improved ... two case studies showing how the breakthrough LENA system ... LENA software enables the clinician to measure adult word ... hourly intervals over the course of an entire day. ...
Cached Medicine News:Health News:Grief Counseling Services Battles Rising Costs of Funeral Expenses 2Health News:Grief Counseling Services Battles Rising Costs of Funeral Expenses 3Health News:MassageLinkUp.com Announces New Massage Directory for Professional Massage Therapists 2Health News:Sexual lyrics in popular songs linked to early sexual experiences 2Health News:Paving the Way for Peace in the Middle East with Mind-Body Skills 2Health News:Paving the Way for Peace in the Middle East with Mind-Body Skills 3Health News:Paving the Way for Peace in the Middle East with Mind-Body Skills 4Health News:Progressive Leaders at White House Summit Today Underscore Need for Health Care Reform 2Health News:LENA Foundation Technology Measures Effectiveness of Autism Therapy 2Health News:LENA Foundation Technology Measures Effectiveness of Autism Therapy 3
(Date:12/17/2014)... Ariz. , Dec. 17, 2014  Beamz ... state-of-the-art interactive music products, today announced that it ... a leading manufacturer and supplier of innovative prosthetic, ... As part of the agreement, RSL Steeper ... bundled solution specifically configured for use within UK ...
(Date:12/17/2014)... and RALEIGH, N.C. , Dec. ... LLC (CTMC), and Integrated Clinical Trial Services, LLC ... retention for clinical trials announce that they have ... Marketing Services (i-CTMS). i-CTMS will provide a broad ... pharmaceutical, biotechnology and medical device companies. ...
(Date:12/15/2014)... Research and Markets ( http://www.researchandmarkets.com/research/32cmct/inferior_vena ) ... Cava (IVC) Filters - Global Trends, Estimates and Forecasts, ... http://photos.prnewswire.com/prnh/20130307/600769 Global Inferior Vena ... million by 2016. The North America ... value while Europe claims approximately ...
Breaking Medicine Technology:Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 2Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 3Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 3Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 2Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 3Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 4
... Genomic Health, Inc. (Nasdaq: GHDX ) today ... to study early-stage renal cell carcinoma prognosis, which demonstrated a ... patient population.  The study, which will be presented in an ... at the ASCO annual meeting in Chicago , could ...
... China , June 4 /PRNewswire-Asia-FirstCall/ -- Jiangbo,Pharmaceuticals, Inc. (OTC Bulletin ... in China , today,announced that the Company has received approval to ... , , ... common stock will begin trading on the NASDAQ,Global Market on Tuesday, ...
Cached Medicine Technology:Genomic Health Announces Results From the Largest Genomic Analysis of Localized Clear Cell Renal Carcinoma at American Society of Clinical Oncology (ASCO) Annual Meeting 2Genomic Health Announces Results From the Largest Genomic Analysis of Localized Clear Cell Renal Carcinoma at American Society of Clinical Oncology (ASCO) Annual Meeting 3Genomic Health Announces Results From the Largest Genomic Analysis of Localized Clear Cell Renal Carcinoma at American Society of Clinical Oncology (ASCO) Annual Meeting 4Genomic Health Announces Results From the Largest Genomic Analysis of Localized Clear Cell Renal Carcinoma at American Society of Clinical Oncology (ASCO) Annual Meeting 5Jiangbo Pharmaceuticals, Inc. Receives Approval to List on the NASDAQ Global Market 2Jiangbo Pharmaceuticals, Inc. Receives Approval to List on the NASDAQ Global Market 3
... you to scan every beating heart at any ... possible. A scanner using two X-ray sources ... provides one-stop diagnosis in acute care; even with ... Combined with the Cardiac Engine, a unique combination ...
... can code the charge while completing a chart ... away from office, both directly feeding the charge ... Encounter Form/Superbill, data entry can be done with ... payments are posted by reflecting open item charges, ...
... lens incorporate 3 mirrors angled at 76°, 66° ... anterior chamber as well as central and peripheral ... mirrors are accurately angled and spaced 120° apart ... The central portion of the lens also provides ...
The Mid Field 30° lens has a bi-concave design to provide a wider field of view with a 30 degree offset image....
Medicine Products: