Navigation Links
Researchers discover possible biomarker and therapeutic target for melanoma
Date:3/17/2011

(Boston) Researchers at Boston University School of Medicine (BUSM), in collaboration with Johns Hopkins University, have identified a potential new biomarker and therapeutic target for melanoma. The novel cell screening method used in the study also clarifies the process behind tumor metastasis and may allow the identification of biomarkers for other aggressive cancers. The findings now appear online in Cancer Research.

According to the American Cancer Society melanoma is the most serious type of skin cancer and one in 55 people will be diagnosed with it during their lifetime. Previous research has found that metastasis causes more than 90 percent of solid tumor deaths throughout the world and is particularly aggressive in melanoma.

The researchers investigated the process through which melanoma cells communicate with blood vessel cells and promote the formation of tube-like conduits that may allow for tumor metastasis. With the combined expertise of the biologists and biomedical engineers they used microfluidics technology to identify molecules that were essential to this communication process. They found that the molecule Neuropilin-2 played a large role in the process and that silencing it inhibited cancer cell growth.

"We found that Neuropilin is an important mediator of melanoma cell and blood vessel cell interactions," said Rhoda Alani, MD, BUSM professor and Chair of Dermatology. "We can now investigate this molecule as a potential biomarker and melanoma treatment target. We can also use the unique methodology developed in these studies to evaluate cellular crosstalk between other tumor cell types and vessel cells. Such studies are likely to provide important insights into the metastatic process for other cancers."

According to the researchers the cell-to-cell communication process necessary for metastasis of tumors has garnered much attention recently but detailed knowledge of its underlying molecular mechanisms is lacking. These findings clarify this process in melanoma tumors and support the use of the team's methods to discover novel factors controlling cell communication for a variety of malignances.


'/>"/>

Contact: Nathan Bliss
nathan.bliss@bmc.org
617-638-8491
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... (PRWEB) , ... July 24, 2017 , ... Paul Vitenas, ... the nation’s top level plastic surgeons, invited to attend Allergan’s recent meeting with their ... most valued companies in the world, Allergan is bringing a newly defined structure to ...
(Date:7/24/2017)... ... 24, 2017 , ... The Magic Wand® Rechargeable, the top-of-the-line ... favorite sex toy. Created in collaboration with website Kinkly.com, the award was the ... The Magic Wand Rechargeable won in stiff competition from brands such as Lelo, ...
(Date:7/24/2017)... PA (PRWEB) , ... July 24, 2017 , ... Summer ... rain storms wreak havoc across communities and often result in massive tree damage requiring ... actions homeowners can take now including tree trimming, tree cabling and hazardous tree removal. ...
(Date:7/24/2017)... ... July 24, 2017 , ... Right now, ... , The agency is hammering out a game plan to implement changes and ... ever to affect FDA-regulated firms. The new law:, ,     Seeks ...
(Date:7/24/2017)... Long Island (PRWEB) , ... July 24, 2017 ... ... of a new office at 2307 Bellmore Avenue, Bellmore, New York, (516) 784-5858. ... dermatologist Jordan Fabrikant, M.D. and physician assistants Lori Friedman and Fruma Leah Wiederman. ...
Breaking Medicine News(10 mins):
(Date:7/12/2017)... LOS ANGELES , July 12, 2017 CarpalAID is ... without drugs, braces or surgery. Carpal tunnel syndrome affects ... tunnel syndrome at twice the rate of men. The common methods ... steroids, or mobilization with uncomfortable hand braces or gloves. ... CarpalAID is a ...
(Date:7/11/2017)... Ill. , July 11, 2017  Sysmex ... and urinalysis diagnostic testing equipment as well as ... innovation: a way to make quality assurance easier ... processes. "Sysmex is well known for the innovation ... Quality Monitor elevates quality assurance processes to ...
(Date:7/10/2017)... , July 10, 2017  BDI Group subsidiary ... patient support services organization serving specialty pharmacies, home ... launch of four significant, value-added member programs designed ... better manage reimbursement and improve access and affordability ... therapies. ...
Breaking Medicine Technology: