Navigation Links
Researchers discover possible approach to the treatment of aggressive breast cancer
Date:3/6/2012

arch study. "For this reason we specifically looked for interaction between these two proteins in breast cancer cells." The Bad Nauheim researchers struck gold. When they switched off Plexin-B1 in breast cancer cells, the cells became incapable of migrating.

"We concluded from this observation that it should be possible to prevent the formation of metastases by switching off Plexin-B1," said Worzfeld. To verify this, they switched off the Plexin-B1 in mice with ErbB-2-producing breast cancer. The effect they observed was very clear: "We were able to establish a drastic reduction in the lung metastases in the animals without Plexin-B1. The effect could even be observed with the naked eye."

The next question to be resolved by the scientists concerned the extent to which this observation could be applied to humans. In a test on tissue from breast cancer patients, the Max Planck scientists noted a link between the Plexin-B1 content of the tumour tissue and the patients' prognoses: patients with very low Plexin-B1 content in their tumour tissue had a considerably better chance of survival.

The scientists are hopeful that these findings will provide a basis for the development of a new treatment. "We want to switch Plexin-B1 off specifically using an antibody and in this way suppress the emergence of metastases," said Worzfeld. The antibody, for which a patent has been filed, is now being tested in the animal model. Offermanns is cautiously optimistic: "With Plexin-B1 we believe we have found a crucial location where the formation of metastases can be blocked. However, we still have a very long way to go until our antibody can be successfully used in clinical practice."


'/>"/>

Contact: Dr. Matthias Heil
matthias.heil@mpi-bn.mpg.de
49-603-270-51705
Max-Planck-Gesellschaft
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers ID gene behind primary cervical dystonia, a neck-twisting disorder
2. Researchers find sarcoma tumor immune response with combination therapy
3. Mayo researchers provide atomic view of a histone chaperone
4. Researchers find potential solution to melanomas resistance to vemurafenib
5. Kessler Foundation researchers present at DC Conference on Race, Ethnicity and Disabilities
6. Researchers Spot Genes Behind Macular Degeneration
7. 90 percent of firefighters exhibit symptoms of PTSD according to Ben-Gurion University researchers
8. New blood test for early cancer detection developed by Ben-Gurion University researchers
9. UC Davis MIND Institute researchers to present on autism at AAAS Annual Meeting in Vancouver
10. Nasty superbug is being studied by UB researchers
11. Researchers see differences in Autism brain development as early as 6 months
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... ... July 07, 2015 , ... U.S. Rep. ... an expanded list of telehealth services available to Medicare beneficiaries. Thompson’s bill, the ... (R-MS 3), Diane Black (R-TN 6) and Peter Welch (D-VT). , “This bi-partisan ...
(Date:7/7/2015)... ... , ... Today, the physicians at Allied Anesthesia, who provide services to Children’s ... counties, released a series of tips to help children stay safe over the summer ... spend more unsupervised time outdoors. , The most common causes of injuries and ...
(Date:7/7/2015)... ... July 07, 2015 , ... WiseWear®, a ... launched their first line of luxury smart jewelry called the Socialite™ collection. The ... ship this fall. , “The Socialite collection was crafted to inspire women ...
(Date:7/7/2015)... ... July 07, 2015 , ... Leading ... expert Jay Warden as Senior Vice President, heading the firm’s Healthcare Advisory Services ... the best solutions to healthcare providers’ needs in ways that strengthen their position ...
(Date:7/7/2015)... ... July 07, 2015 , ... ... the Southwest, including Giant, Mustang, Sun Dial and Howdy’s, raised more than ... original 2015 fundraising goal by nearly $100,000, to help support children fighting ...
Breaking Medicine News(10 mins):Health News:The American Telemedicine Association Supports Legislation to Expand Medicare Coverage for Telemedicine Services 2Health News:Allied Anesthesia Physicians Release Summertime Safety Tips 2Health News:Allied Anesthesia Physicians Release Summertime Safety Tips 3Health News:WiseWear Unveils Luxury Smart Jewelry Line 2Health News:Hammes Company Hires Jay Warden to Lead Healthcare Advisory Services 2Health News:Hammes Company Hires Jay Warden to Lead Healthcare Advisory Services 3Health News:Western Refining Raises $524,286 to Help Send Kids with Neuromuscular Disease to MDA Summer Camp 2Health News:Western Refining Raises $524,286 to Help Send Kids with Neuromuscular Disease to MDA Summer Camp 3
... , RALEIGH, N.C., Nov. 16 Blue Water Spa, a Raleigh ... Raleigh with an anniversary party and Raleigh food drive. Guests who ... One lucky winner will receive a $10,000 spa gift certificate for ... of NC will be on hand Wed. November 18 and Saturday ...
... SINGAPORE, Nov. 16 /PRNewswire-Asia/ -- Retail ... steadily in the first half of 2009 with,total consumption peaking ... major Contact Lens manufacturers. Positive sales,data showing a growth of ... an economic recovery that is being led by consumers spending. ...
... every household has some sort of a first aid kit filled ... plan ahead for dental emergencies? , According to a recent ... products, although one in six Americans had a dental emergency during ... the problem. , "You keep medical supplies on hand for ...
... ... it says there is no solidity or separation, as commonly understood, between any physical ... religion, economics; and create world peace, eternal life and time travel. , ... (PRWEB) November 16, 2009 -- This is intended ...
... ... impairments caused by Alzheimer,s disease, Traumatic Brain Injury, ADD, Schizophrenia and more. , ... (PRWEB) November 16, 2009 ... rehab tools for a variety of cognitive disorders at the American Medical Informatics ...
... ... Science’s “Best of What’s New” in 2009 for their HyGreen™ hand washing system. ... Sarasota, FL ... Science’s “Best of What’s New” in 2009 for their HyGreen™ hand washing system. Xhale, ...
Cached Medicine News:Health News:Raleigh Day Spa, Blue Water Spa, Raffles Off $10,000 in Day Spa Packages for Contributing to Raleigh Food Drive 2Health News:GfK Asia Reports: Malaysian Contact Lens Market Sees Strong Recovery in Second Half of 2009 2Health News:GfK Asia Reports: Malaysian Contact Lens Market Sees Strong Recovery in Second Half of 2009 3Health News:Be Prepared for a Dental Emergency During the Holidays 2Health News:New View Of Reality (In Printed Book Form) That Combines Einstein And Quantum Mechanics, And Fills The World With Miracles 2Health News:New View Of Reality (In Printed Book Form) That Combines Einstein And Quantum Mechanics, And Fills The World With Miracles 3Health News:HAPPYneuron Launches Beta Program for Innovative Cognitive Rehab Tools at AMIA Conference in San Francisco 2Health News:HAPPYneuron Launches Beta Program for Innovative Cognitive Rehab Tools at AMIA Conference in San Francisco 3Health News:Xhale Recognized in Popular Science's "Best of What's New" with hand from ROBRADY design 2
(Date:7/7/2015)... FREMONT, Calif. , July 7, 2015  The ... and Velos, Inc. have entered into a seven year ... research nationally throughout South Korea and ... signing was accompanied by a two day joint workshop between ... Korea.  National Cancer Center President Dr. Lee ...
(Date:7/7/2015)... , Kalifornien, 7. Juli 2015 /PRNewswire/ ... Medizintechnikunternehmen, das sich der Entwicklung innovativer Geräte ... heute den Zugang von R. Michael ... Herr Kleine verfügt über eine ... Medizintechnik und Gesundheitsfürsorge. Er hat verschiedene globale ...
(Date:7/7/2015)... Md. , July 7, 2015 ... (CRO) focusing in Oncology, Vaccines, and General Medicine ... the final locked database to Heron Therapeutics, Inc. ... 3 receptor antagonist product candidate SUSTOL® (granisetron ... regimen with the IV NK 1 receptor ...
Breaking Medicine Technology:National Cancer Center of South Korea and Velos Sign Long-Term Velos eResearch Agreement 2National Cancer Center of South Korea and Velos Sign Long-Term Velos eResearch Agreement 3Sequent Medical beruft Mike Kleine in den Aufsichtsrat 2Sequent Medical beruft Mike Kleine in den Aufsichtsrat 3Accelovance Completes Trial Enrollment and Delivery of Clinical Data for Heron Therapeutics' Phase 3 Trial 2
... ALTO, Calif., Jan. 10, 2012 Varian Medical Systems (NYSE: ... a new radiotherapy treatment planning tool designed to work with ... the amount of time needed for planning advanced treatments. ... clinician must take the patient,s anatomical images and identify and ...
... Agreement allows development for potential treatment of chronic constipation ... SHPGY ), the global specialty biopharmaceutical company, announced today ... market Resolor ® (prucalopride) in the United States ... of the agreement have not been disclosed. ...
Cached Medicine Technology:Varian Medical Systems Receives FDA 510(k) Clearance for Software that Speeds Up Radiotherapy Treatment Planning 2Shire Acquires US Rights to Resolor(R) (prucalopride) 2Shire Acquires US Rights to Resolor(R) (prucalopride) 3Shire Acquires US Rights to Resolor(R) (prucalopride) 4
Curved shafts and tips with 7 mm tying platform. Serrated handle with polished finish. Overall length 4 inches....
Straight shafts with 5 mm tying platform. Wide handle with dull finish. Overall length 4.3 inches....
Straight shafts with 7 mm tying platform. Flat serrated handle with dull titanium finish. Overall length 4.5 inches....
Curved shafts with 4 mm tying platform. Serrated handle with dull finish. Manufactured in titanium. Overall length 3.3 inches....
Medicine Products: