Navigation Links
Researchers discover patterns of genes associated with timing of breast cancer recurrences
Date:12/6/2011

SAN ANTONIO -- An international research team led by Georgetown Lombardi Comprehensive Cancer Center has found biological differences in hormone-receptor positive breast cancer that are linked to the timing of recurrence despite endocrine therapy.

They say their findings, presented at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium, may help oncologists find ways to individualize systemic therapy to delay or prevent recurrences, and to avoid excessive treatment of patients who will never recur.

"We found that, at the time of diagnosis, there are clear biological differences within the supposedly uniform group of hormone receptor positive breast cancers, and these differences distinguish subtypes relative to the time at which they recur," says Minetta Liu, M.D., director of translational breast cancer research at Georgetown Lombardi Comprehensive Cancer Center.

"We need to exploit these differences and use our data to figure out what drives a tumor to never metastasize. Then we will try to manipulate the cancers that are programmed to recur to act like that of the non-recurrences," she says.

Tamoxifen is credited with saving the lives of thousands of women with estrogen receptor-positive (ER+) breast cancer, which accounts for two-thirds of all diagnoses of invasive breast cancer in the United States. As the world's leading breast cancer treatment and prevention drug, tamoxifen can stave off cancer recurrences for more than 10 years in some patients, but for others, the cancer returns much earlier.

To determine why some ER+ cancers treated with tamoxifen recur earlier rather than later, if at all, Liu and her Georgetown team collaborated with researchers at the University of Edinburgh and with engineers at Virginia Tech.

The Scottish collaborators shared high quality tumor biopsies collected from patients with different stages of breast cancer before they had started tamoxifen therapy. Critical clinical information was
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
Georgetown University Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. University of Kentucky researchers awarded CDC grant to study cancer survival in Appalachia
2. Moffitt researchers will be strong participants in American Society of Hematology meeting
3. Moffitt Cancer Center researchers find MK1775 active against sarcomas
4. MU researchers recommend exercise for breast cancer survivors, lymphedema patients
5. NSF awards University of Arizona researchers $530,000 for development of new spectral imager
6. Cleveland researchers find possible breakthrough to relieve pain following spinal cord injury
7. Researchers examine role of inflammatory mechanisms in a healing heart
8. WSU researchers use a 3D printer to make bone-like material
9. Presumed consent not answer to solving organ shortage in US, researchers say
10. Researchers validate preclinical effectiveness of TB drug target
11. Researchers surprised to find fatty liver disease poses no excess risk for death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... News) -- Over the next two decades, the cost ... to more than double, topping more than $180 billion ... factor driving the increase: an aging population. The report, ... Stroke Association, was published May 22 in the journal ... health care system," Dr. Bruce Ovbiagele, chairman of the ...
(Date:5/22/2013)... HealthDay Reporter , , WEDNESDAY, May 22 (HealthDay ... great deal of suffering, but new research indicates the ... else entirely -- a smaller brain. , , Already ... of depression, scientists wanted to determine if having both ... size -- about 2 percent -- isn,t alarming, study ...
(Date:5/22/2013)... Johns Hopkins researchers report that hospitals may be ... are complicated by preventable bloodstream infections contracted in ... new study, reported online in the American ... that an ICU patient who develops an avoidable ... times more to care for than a similar ...
(Date:5/22/2013)... 22, 2013 Award Presented at the ... press release here: http://bit.ly/13DkFfk , Merrill Corporation ... “Information Management Product/Service of the Year” at the 7th ... The Colony Hotel in Palm Beach, Florida. , ... room (VDR) solution that optimizes the due diligence ...
(Date:5/22/2013)... 22, 2013 Phelps Memorial Hospital Center ... Westchester Lung Nodule Center for individuals who would like ... care. Lung cancer is the deadliest form of cancer for ... the U.S. die from lung cancer than from breast, colon ... early detection increases survival rates. It is well established ...
Breaking Medicine News(10 mins):Health News:Cost of Treating Strokes in U.S. Could Soar to $180B Annually by 2030: Report 2Health News:Cost of Treating Strokes in U.S. Could Soar to $180B Annually by 2030: Report 3Health News:Having Both Migraines, Depression May Mean Smaller Brain 2Health News:Having Both Migraines, Depression May Mean Smaller Brain 3Health News:Hospitals profit when patients develop bloodstream infections 2Health News:Hospitals profit when patients develop bloodstream infections 3Health News:Hospitals profit when patients develop bloodstream infections 4Health News:Merrill DataSite New Press Release: Merrill DataSite® Virtual Data Room Honored as “Information Management Product/Service of the Year” 2Health News:Merrill DataSite New Press Release: Merrill DataSite® Virtual Data Room Honored as “Information Management Product/Service of the Year” 3Health News:Phelps Memorial Hospital Center Establishes The Westchester Lung Nodule Center To Diagnose And Administer Lung Cancer Care 2Health News:Phelps Memorial Hospital Center Establishes The Westchester Lung Nodule Center To Diagnose And Administer Lung Cancer Care 3
... Recent study reports that women don’t have to worry about their ... fertility is higher only in their thirties. // Women don’t have ... be a constraint for conception of babies. Researchers have found from ... as man as increased considerably. The fertility rate of women in ...
... as formed a new cabinet committee to plan strategies to ... has said that though the United Kingdom //Government has taken ... flu spread but the committee feels still a lot has ... ,The committee feels that the Government should organize the food ...
... Motion has been developed by University of Toronto scientists with ... again. The device makes the muscles// work again by sending ... called functional electrical stimulation or FES, is unlike similar therapies ... is not dependent on the machine. ,Instead, the ...
... it takes to get pregnant or conceive the sex of the ... by Dutch reserachers. //The sample size was 5,283 women who gave ... ,Among the 498 women who took longer than 12 months ... whereas the proportion of male births among the 4,785 women with ...
... UK Parliamentarian Roger Williams has called for a ban ... the production of 6,000 types of medicines, food and ... the sweetener, which is used in cereal, chocolate and ... published reports that aspartame caused cancer in rats. Doses ...
... the Government in treating drug addicts is beginning to yield ... users seeking treatment in 2004. Heroin users accounted for 8,000 ... the number of people trying to get back to normal ... the figures, which also said that the percentage of heroin ...
Cached Medicine News:
(Date:5/22/2013)... , May 22, 2013  Flagship Ventures, a ... on healthcare and sustainability, today announced the appointment ... a Senior Partner. In this role, Mr. Bancel ... companies. In addition to working closely ... also serves as President and Chief Executive Officer ...
(Date:5/22/2013)... and TORONTO , May 22, ... today that John Mon , Chief Operating ... Conference on Thursday, May 30, 2013 in New ... The Company,s presentation is scheduled to begin at ... webcast. To access the webcast, go to:   http://wsw.com/webcast/marcum/mfs.v/   ...
(Date:5/22/2013)... May 22, 2013 While many parents may ... to drink at home under adult supervision keeps kids ... truth is that there are serious negative consequences for ... and The Treatment Research Institute (TRI) ... resource for parents and caregivers to help inform them ...
Breaking Medicine Technology:Life Science Industry Veteran Stephane Bancel Joins Flagship Ventures 2Life Science Industry Veteran Stephane Bancel Joins Flagship Ventures 3Medifocus, Inc. to Present At The Second Annual Marcum LLP MicroCap Conference 2Medifocus, Inc. to Present At The Second Annual Marcum LLP MicroCap Conference 3Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 2Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 3Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 4Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 5Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 6Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 7
... July 14 D3 Radiation Services announced today  that the ... reduce errors in the delivery of radiation therapy--as a Practice Quality Improvement ... , , ... radiation oncology physicists can order a comprehensive audit of their beam data ...
... 14 Mylan Inc. (Nasdaq: MYL ) ... received final approval from the U.S. Food and Drug ... for Nabumetone Tablets USP, 500 mg and 750 mg. ... therapeutically equivalent to Nabumetone Tablets, a treatment for osteoarthritis ...
Cached Medicine Technology:eDataAudit Receives Approval from the American Board of Radiology 2Mylan Receives Approval for Nabumetone Tablets 2
Straight, with guard. Ideal for multi-directional manipulation....
Vaulted shank with guard....
Vaulted shank. For engaging the inferior haptic without touching the dome of the IOL....
... adjusted for perfect focus where it's needed ... This, along with Keeler's wide angle light ... the patient's pupil size, you will see ... Lithium-ion technology provides a longer life battery ...
Medicine Products: