Navigation Links
Researchers discover new weapon in fight against cervical cancer
Date:5/30/2013

Scientists at the University of Leeds have found a way to target and destroy a key protein associated with the development of cervical and other cancers.

The E7 protein is produced early in the lifecycle of the human papillomavirus (HPV) and blocks the body's natural defences against the uncontrolled division of cells that can lead to cancer.

Researchers at the University of Leeds' School of Molecular and Cellular Biology have synthesised a molecule, called an RNA aptamer, that latches onto the carcinogenic protein and targets it for destruction, significantly reducing its presence in cells in the laboratory derived from cervical cancers.

There are many types of human papillomavirus. Some are transmitted by sexual contact and associated not only with cervical cancer but also head and neck cancer. Although an increasing proportion of young women in the United Kingdom are vaccinated against the virus, most women in their mid-20s or older are not vaccinated and many may already be HPV positive.

"We therefore need to maintain screening and to develop novel therapeutic strategies," lead researcher Dr Nicola Stonehouse said. "Currently, if you have advanced cervical cancer or head and neck cancerboth of which are associated with human papillomavirusyou really have little choice but surgery. If we can use this aptamer to target the carcinogenic protein, we might be talking about much less radical surgery in the future."

Aptamers are a relatively new tool for molecular biologists and a topic of intense research interest. Like the much better understood antibodies, aptamers can identify and target other molecules as well as viruses and bacteria. However, unlike traditional antibodies, they offer the possibility of insertion into live cells and can be artificially designed in the test tube.

The Leeds team, which received funding from Yorkshire Cancer Research and the BBSRC, was originally looking for an aptamer fo
'/>"/>

Contact: Chris Bunting
c.j.bunting@leeds.ac.uk
44-113-343-2049
University of Leeds
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... Los Angeles, CA (PRWEB) , ... July 30, 2015 , ... The connection between a ... men and women. The loss of a full head of hair can have a ... to how a person is perceived in the work place, the consequences of hair loss ...
(Date:7/30/2015)... ... July 30, 2015 , ... Mullin/Ashley Associates, ... of three awards in the Service Industry Advertising Awards 12th annual national competition. ... KRM Development Corporation and University of Maryland Shore Regional Health. , A Gold ...
(Date:7/30/2015)... County, CA (PRWEB) , ... July 30, 2015 ... ... home health care throughout Orange, Riverside, Los Angeles, and San Bernardino counties, today ... as the new Palliative Care Administrator. Dr. Demoratz is a strong proponent of ...
(Date:7/30/2015)... ... July 30, 2015 , ... OncLive®’s extensive ... UCLA’s Jonsson Comprehensive Cancer Center (JCCC) mutually agreed to collaborate on projects ... editorial and marketing groups will help spread the news about the center’s leading-edge ...
(Date:7/30/2015)... FL (PRWEB) , ... July 30, 2015 , ... Using ... eradicate suicide and teach people more effective ways to prevent and manage major depression. ... to react fast enough, so people fall through the cracks and die needlessly everyday,” ...
Breaking Medicine News(10 mins):Health News:New Study Shows the Link between Hair Restoration and Healthy Self-Image 2Health News:Mullin/Ashley Associates Takes Home Wins for Three Clients in the Service Industry Advertising Awards Annual Competition 2Health News:Mullin/Ashley Associates Takes Home Wins for Three Clients in the Service Industry Advertising Awards Annual Competition 3Health News:24/7 Care At Home Welcomes Michael Demoratz, PhD, LCSW, CCM as New Palliative Care Administrator 2Health News:24/7 Care At Home Welcomes Michael Demoratz, PhD, LCSW, CCM as New Palliative Care Administrator 3Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 2Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 3Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 4Health News:Happiness Expert Develops Pioneering Online Tools for Sufferers of Major Depression, and Who may be Suicidal 2Health News:Happiness Expert Develops Pioneering Online Tools for Sufferers of Major Depression, and Who may be Suicidal 3
... an apology after a diabetic man who suffered a burnt ... with a misdiagnosis of gangrene.// Derek Atkinson, 56, from Newton ... consultant at Bishop Auckland General Hospital. ,In November ... and since the symptoms seemed very much like the previous ...
... increasing exponentially in over-50s in Scotland causing widespread concern. ... diseases had more than trebled in this segment of ... are also rising rapidly in senior citizens in Scotland. ... safe sex message. ,The rise in infections ...
... E D Marak, who was hospitalised here yesterday with ... ,'Marak's temparature has now become normal, so ... of state-run civil hospital Dr B Garod told PTI ... and symptoms of Malaria after returning from a visit ...
... Pradesh government Tuesday ascribed the increase in the number of ... year - to an increase in the number of HIV ... by Congress legislators Sajjan Singh Verma and Govind Singh, on ... Minister Ajay Vishnoi said: "The number of HIV test centres ...
... and other tobacco products will carry a sign of a ... packets from Feb 1, 2007, the health ministry// said Tuesday. ... product must bear a skull-and-bones sign, a health warning saying ... effects of tobacco use and a health message. ...
... HIV/AIDS, a Community Based Organisation (CBO) was launched here ... Initiative Roots) would bring together hundreds of transgenders from ... at empowering and enabling the community to undertake and ... vision of the newly formed collective was to ensure ...
Cached Medicine News:
(Date:7/30/2015)... July 30, 2015  ResMed Inc. (NYSE: RMD ... 30, 2015.  Revenue for the quarter was $453.1 million, ... June 30, 2014 (a 17 percent increase on a ... with the quarter ended June 30, 2014.  Diluted earnings ... the quarter ended June 30, 2014.  ...
(Date:7/30/2015)... and VANCOUVER , July 30, 2015 ... today that it will report its second quarter 2015 ... will host a conference call and live webcast at ... financial results, clinical development programs and a general corporate ... on to the Investor Relations page of the OncoGenex ...
(Date:7/30/2015)... , July 30, 2015  Cleveland Clinic President ... 2015 keynote address last month that industry is compelled ... order to gain the efficiencies—and develop the transformational innovations ... Dr. Barsoum,s comments were preceded by Doug Kohrs ... and OMTEC moderator, who stressed that industry must add ...
Breaking Medicine Technology:ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 3ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 4ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 5ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 6ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 7ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 8ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 9ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 10ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 11ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 12ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 13ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 14ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 15ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 16Orthopaedic Surgery Reimbursement Shifts to Episode of Care 2
... HAMBURG , Feb. 3 , The International ... a global teleconference that will: , Detail the launch of ... its symposium in Hamburg being held February 5-6, ... develop a comprehensive, evidence-based consensus on the use of NPWT; ...
... BALTIMORE , Feb. 2 Celsis In Vitro, Inc. ... lawsuit against XenoTech LLC, Sekisui Chemical Co. Ltd., and Sekisui Medical ... District of Illinois in Chicago .  XenoTech and ... that certain processes and methods performed by XenoTech associated with its ...
Cached Medicine Technology:The International Negative Pressure Wound Therapy Expert Panel to Announce Results of Inaugural Symposium in Hamburg 2Celsis Initiates Patent Infringement Action Against XenoTech and Sekisui 2Celsis Initiates Patent Infringement Action Against XenoTech and Sekisui 3
... Mini-TrueView Arthroscopes,Based on the TrueView II design, ... optic telescopes for small joint arthroscopy is ... autoclavable and very durable thanks to Olympus ... new telescope class means bright images, brilliant ...
... to provide excellent protection and ease of ... being closer to an adhesive in molecular ... CoEase to maintain viscosity at high shear ... worlds for superb performance during capsulorhexis, phaco, ...
151 channels cover the entire head with a high density, with provisions for the eyes and ears. Patients and subjects are examined in a comfortable seated position or laying down....
... for evaluating a wide range of functions of ... Often referred to at the "whole body" MSI ... spinal cord and peripheral nerve studies, are expanding ... detector coils, covers a circular area approximately 32 ...
Medicine Products: