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Researchers discover new way to reverse poor circulation and heal wounds
Date:2/14/2008

cid sequence designed to link up with heparin and heparin-like molecules. Going into the current study, Hocking had already built this heparin-binding fragment separately from its larger parent protein.

The current team injected the heparin-binding fibronectin fragment into anesthetized animals. As expected, the fragment alone triggered a rapid and reversible dilation of nearby, small blood vessels. Furthermore, the effect was blocked by the addition of a nitric oxide inhibitor. This confirmed that the fragment signals for dilation by causing the release of the well-known vasodilator, nitric oxide, and perhaps by binding to heparan sulfate proteoglycan molecules on the surface of smooth muscle cells.

It takes energy to move fibronectin out of the bloodstream, assemble it into ECM fibrils, and open its cryptic site, Hocking said. Injecting recombinant fibronectin fragments, engineered to express an "open" version of the site, directly onto tissues should bypass these energy requirements, and increase blood vessel dilation in patients. Furthermore, exposing the fibronectin cryptic site is known to increase cell growth and migration, processes that are central to wound healing. Applying topical ointments that contain our engineered fibronectin fragments to chronic wounds should increase nutritive blood flow to accelerate healing.


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Contact: Greg Williams
greg_williams@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

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