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Researchers discover new way to reverse poor circulation and heal wounds
Date:2/14/2008

ing blood flow through them. The authors have also shown that a key piece of fibronectin, on its own, causes blood vessels to dilate, a first step toward pro-circulatory drug design.

Along with a fundamental contribution to the understanding of exercise physiology, our data study suggests that engineering fibronectin could provide a simple, elegant way to maintain normal blood vessel function in the aging, and to restore such function in hard-to-heal wounds, said Ingrid H. Sarelius, Ph.D., professor of Pharmacology and Physiology at the University of Rochester Medical Center, and a study author. Aging and disease bring changes in matrix structure, and we may be able to reverse them.

Twitching Muscles

As a physiologist interested in the bodys response to exercise, Sarelius has for many years been studying the responses of surrounding tissue to muscle fiber contraction. Muscles are generally made up of a mix of fast-twitch fibers; which shorten rapidly for delivery of explosive power, say for a 100-yard dash, but then quickly fatigue; and slow-twitch fibers, which produce less power but keep flexing as oxygen supply dwindles during a long-distance run. Fast-twitch fibers should need more fuel to bring about a greater dilation in the vessels supplying them, but her experiments found no difference in initial dilation of vessels between twitch types. Some unknown mechanism was influencing the degree to which blood vessels dilate in response to muscle flex.

Meanwhile, the current studys lead author, Denise C. Hocking, Ph.D., associate professor of Pharmacology and Physiology at the Medical Center, had been studying how the ECM protein fibronectin affects cell signaling and function.

Past studies in her laboratory had found that fibronectins structure to include a binding site, a place where most of its interactions with other proteins and cells take place, and which is key to its ability to pass on biochemical mess
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Contact: Greg Williams
greg_williams@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

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