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Researchers discover new way to predict survival in older women with lung cancer
Date:11/1/2007

s conventional therapies aren't effective.

"This was a true multidisciplinary team effort," Goodglick said. "Each person was critically important."

The study included researchers from the UCLA departments of pathology and medicine, the UCLA lung cancer SPORE program and the Jonsson Comprehensive Cancer Center, as well as experts in biostatistics. The next step for researchers will be to continue their work with an even larger patient population at multiple cancer centers nationwide. This will help determine the framework by which physicians might use this test effectively in the clinic. Defining the role that estrogen and the estrogen pathway play in lung cancer and devising way to intervene at each step, tailored to a specific patient, will also be key, Goodglick said.

"We need to figure out all the strategies that a lung cancer cell uses to trigger and amplify the estrogen pathway," he said. "In women over 65, one trick the cancer cells appear to use is increasing aromatase it remains an interesting mystery what strategy the cancer cells are using in women under 65 and in men. Identifying which branch of the estrogen pathway is hijacked by cancer cells will allow us to specifically attack that branch on a person-by-person basis. I think this study is one important step in that direction."


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Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

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