Navigation Links
Researchers discover new way to kill pediatric brain tumors
Date:2/9/2010

cular Imaging Center at Washington University. The results appear this month in the journal Cancer Research.

Cucurbitacin-I, the compound that led scientists to STAT3, is a plant steroid. It belongs to a family of bitter-tasting compounds previously identified as inhibitors of STAT3. Gutmann says cucurbitacin-I is likely too toxic to be suitable for use in clinical trials at this time.

After the successful robotic test of cucurbitacin-I, researchers showed that STAT3, which turns on and off the activity of a number of genes, is unusually active in NF1 tumor cells. Further investigation revealed that STAT3 activity is regulated by another gene very familiar to Gutmann: the mammalian target of rapamycin (mTOR).

Gutmann's laboratory linked mTOR and the processes it controls to NF1 years ago. The new connection between STAT3 and the mTOR pathway makes STAT3 the last link in a chain of molecules that take growth-promoting signals from the cell membrane to the nucleus. Gutmann says he is encouraged by the possibility that scientists might be able to decipher the genetic program controlled by STAT3 in order to develop more refined treatments for tumors in patients with NF1.

"We went in with a 'we don't know enough' approach, let's try 'ready, fire, aim,' and it paid off," he says.


'/>"/>
Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
2. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
3. UCSF Researchers Identify Regulator of Human Sperm Cells
4. Researchers find broad spectrum antiviral that fights multitude of viruses
5. Caregivers of ICU patients are collateral damage of critical illness, say Pitt researchers
6. Researchers fight world hunger by mapping the soybean genome
7. HIV researchers solve key puzzle after 20 years of trying
8. UC Davis researchers identify brain protein for synapse development
9. UCLA cancer researchers perform complete genomic sequencing of brain cancer cell line
10. Researchers find new way to study how enzymes repair DNA damage
11. UCLA researchers image earliest signs of Alzheimers, before symptoms appear
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... age with kidney and heart disease have raised concerns ... adults. However, in the first study to look closely ... Medicine at the University of Pennsylvania report that older ... expectancy and cardiovascular health as very healthy older people ... the ever increasing organ transplant waitlists, the authors of ...
(Date:7/9/2014)... occurrence of allergic diseases has risen dramatically in Western ... less exposed to microorganisms and have fewer infections than ... , A study by researchers at Sahlgrenska Academy, University ... to examine maturation of the immune system in relation ... rural areas of the Vstra Gtaland Region, half of ...
(Date:7/8/2014)... The UCLA Program in Memory Restoration has been awarded ... Projects Agency (DARPA) for a four -year project aiming ... UCLA team of experts in neurosurgery, engineering, neurobiology, psychology ... test a memory prosthesis in the brain. , Memory ... of the brain encode information, store it and retrieve ...
(Date:7/8/2014)... be three times higher when auditors were visible to ... according to a study in a major Canadian acute ... the Hawthorne effect in hand hygiene compliance monitoring using ... today on-line in the BMJ Quality & Safety ... did the study as part of her Master,s thesis ...
(Date:7/8/2014)... obesity have increased risks of dying at a young ... disease, stroke, diabetes, and kidney and liver diseases, according ... 20 large studies of people from three countries. The ... (NCI), part of the National Institutes of Health, found ... a dramatic reduction in life expectancy compared with people ...
Breaking Medicine News(10 mins):Health News:Penn study finds living kidney donation does not increase risk of death or heart disease for older 2Health News:DARPA awards UCLA $15 million to restore lost memory 2Health News:DARPA awards UCLA $15 million to restore lost memory 3Health News:Health-care worker hand hygiene rates increase three-fold when auditors visible 2Health News:Health-care worker hand hygiene rates increase three-fold when auditors visible 3Health News:NCI study finds extreme obesity may shorten life expectancy up to 14 years 2
... treating a rare disease does not amount to deficiency ... dismissed the medical negligence claim case to the tune ... whose wife died almost nine years ago here after ... Consumer Disputes Redressal Commission Bench, presided by Justice M ...
... June 1: The apex consumer court in New Delhi on ... that was filed by an Indian born// US scientist Kunal ... he alleged due to the wrongful treatment. ,Making ... the National Consumer Disputes Redressal Commission (NCDRC) was utterly shocking ...
... son of late BJP leader Pramod Mahajan, is 'serious ... hopital here in the wee hours // , while ... ,'Rahul's condition is serious but stable, all his vital ... told PTI. ,Asked about the cause of Mahajan's ...
... United nation today announced that the world would require US ... year 2008.// However, it is not sure from where the ... special session to address the issue of AIDS, UN members ... antiretroviral drugs which has lowered the cost of treatment., ...
... on smoking in public places, which came into effect on ... the ban be suspended for 30 days after tobacco companies ... ,The companies, notably British American Tobacco and Mastermind, ... it came into effect and thus they did not have ...
... 10 million American children get 'spellbound' in local contests every ... Indian American, making it// to the finals of the prestigious ... began Wednesday. ,With the bee's soaring popularity, the ... TV for the first time as 139 boys and 136 ...
Cached Medicine News:Health News:Court Dismisses 143-Crore Claim Against Hospital In Kolkata For Alleged Negligence In Treatment 2Health News:Court Dismisses 143-Crore Claim Against Hospital In Kolkata For Alleged Negligence In Treatment 3Health News:Indian Americans Compete for the Prestigious Spelling Bee Contest 2
(Date:1/15/2014)... , Jan. 15, 2014  Humberto C. Antunes,  Galderma  ... Award" from the Journal of Drugs in Dermatology ... Clinical Conference (ODAC). The event is January 17-20, 2014, at the ... . The ODAC is a ...
(Date:1/15/2014)... PALM BEACH GARDENS, Fla. , Jan. 15, 2014  In an ... C. difficile and TB in ambulances and other transport vehicles, an ... being used by rescue personnel for the first time. ... coming in contact with these deadly pathogens, West Palm ...
(Date:1/15/2014)... PHILADELPHIA , Jan. 15, 2014  Echo Therapeutics, Inc. ... company developing its Symphony® CGM System as a non-invasive, ... Robert F. Doman , Executive Chairman and Interim CEO ... Capital Markets, Tenth Annual Equity Conference. ...
Breaking Medicine Technology:Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4Superbugs No Longer Ride In Rescue Vehicles 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3
... HIV Vaccine--PHILADELPHIA, May 17 A research team may ... invention of an effective HIV vaccine, by using an ... developers. By using gene transfer technology that produces molecules ... by a virus closely related to HIV -- the ...
... Findings Confirm Glycerin Accelerates the Healing Process , ... Today , a leading expert ... from a study demonstrating that glycerin helps to speed ... resulting in less bruising and skin discoloration.In a double-blinded, ...
Cached Medicine Technology:Novel Vaccine Approach Offers Hope in Fight Against HIV 2Novel Vaccine Approach Offers Hope in Fight Against HIV 3Glycerin Proven to Improve Bruising and Swelling Caused By Trauma to Skin 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: