Navigation Links
Researchers discover new hormone receptors to target when treating breast cancer
Date:2/4/2014

Boston, MA According to the United States Centers for Disease Control and Prevention, breast cancer is the most common cancer in women. For patients whose breast cancers are hormone-dependent, current treatment focuses on using drugs that block estrogen (a type of hormone) from attaching to estrogen receptors on tumor cells to prevent the cells from growing and spreading.

In a new study, first study author, Sandro Santagata, MD, PhD, Brigham and Women's Hospital (BWH) Department of Pathology, and senior study author Tan A. Ince MD, PhD, University of Miami Miller School of Medicine (formerly of BWH Department of Pathology), along with a team of researchers from both institutions found that there are other receptors that can be targetedandrogen and vitamin D receptors.

The findings offer the possibility of expanding the ways patients with breast cancer are treated with hormone therapy.

"These findings may change how we treat breast cancer," said Santagata. "Since at least 50 percent of patients with breast cancer express all three receptorsestrogen, androgen and vitamin D in their tumor cells, this may allow clinicians to consider triple hormone treatments, which is a new concept, as opposed to treating patients by targeting only estrogen receptors."

The study published online in the Journal of Clinical Investigation.

When clinicians categorize human breast cancer tumors, they do so by grouping them into one of three categories based on the type of receptor present or absent on the tumor: estrogen receptor (ER positive/negative), progesterone receptor (PR positive/negative), and human epidermal growth factor receptor 2 (HER2 positive/negative).

In the study, the researchers explored the landscape of cells that make up the surfaces of breast tissue to provide a better definition of the subtypes of cells present on these surfaces. They studied more than 15,000 normal breast cells and discove
'/>"/>

Contact: Jessica M Maki
jmaki3@partners.org
617-525-6373
Brigham and Women's Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Kessler Foundation MS researchers study predictors of employment status
2. RI Hospital researchers identify components in C. diff that may lead to better treatment
3. Researchers create database to examine vast resources of health legacy foundations
4. UC Irvine stem cell researchers awarded $1.54 million in state funding
5. Researchers find novel approach for controlling deadly C. difficile infections
6. Researchers open door to new HIV therapy
7. Researchers find changes to protein SirT1
8. Researchers use sensory integration model to understand unconscious priming
9. CWRU researchers find epileptic activity spreads in new way
10. IU School of Medicine researchers awarded $300,000 GE/NFL grant to study concussions
11. UGA researchers discover origin of unusual glands in the body
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... of a surgical procedure to treat severe chronic migraine ... percent of the time in patients treated at Massachusetts ... of Plastic and Reconstructive Surgery report that more than ... all of whom had headaches associated with compression ... year later. The team,s paper has received advance ...
(Date:7/28/2014)... Cape Regional Medical Center, is currently ... solution in an effort to streamline its bi-directional ... their New Jersey health information exchange (NJSHINE). , ... New Jersey, serves the local population and more ... inpatient and outpatient services. With a strong commitment ...
(Date:7/28/2014)... MONDAY, July 28, 2014 (HealthDay News) -- Endurance runners ... than an undetected heart condition, according to a new ... athletes participating in events in warm climates are actually ... heat stroke. Yet, the less common sudden death of ... heart problems, such as an irregular heartbeat, often gets ...
(Date:7/28/2014)... 2014 The Oakwood Foundation celebrated a ... Songe and Associates, PC that will benefit each community ... come. , The HBWS group is among the ... $2.5 million in donations. Through their latest gift, they ... Oakwood Women’s Healthcare Classic for the next 6 years; ...
(Date:7/28/2014)... brain was able to arouse animals receiving general anesthesia ... issue of Anesthesiology , investigators from Massachusetts General ... of either agent would move, raise their heads and ... to the ventral tegmental area (VTA). Stimulation of ... not induce the animals to wake up. , ...
Breaking Medicine News(10 mins):Health News:Non-endoscopic migraine surgery provides significant symptom relief 2Health News:Cape Regional Medical Center Chooses Summit Provider Exchange to Connect With NJSHINE and Physician Offices 2Health News:Cape Regional Medical Center Chooses Summit Provider Exchange to Connect With NJSHINE and Physician Offices 3Health News:Heat Stroke a Greater Threat to Endurance Runners Than Heart Problems: Study 2Health News:Stimulation of brain region restores consciousness to animals under general anesthesia 2
... female cells are able to choose randomly between their two X ... ,Human males have both a X and a Y chromosome but ... stage in the development of a womans fertilised egg the cells ... is crucial to survival and problems with the process are related ...
... zealots. But they seem to have had the sense to ... vulnerable points . The move is paying dividends, officials say. ... films in Surat has succeeded in spreading awareness of the ... of migrant laborers who come to the city to work ...
... tables by declaring that some recent imports of raisins from ... them . That was apparently in retaliation to the barrage ... exported by China. ,But the Asian giants satisfaction ... hospitals and pharmacies in the north-eastern part of the country ...
... caused due to a syringe used on an AIDS patient infect ... your body in sufficient quantity for you to get infected . ... with HIV from a barber's razor. Is it true most of ... infected with HIV are housewives and a majority of them, over ...
... deprivation can do more than leave you short-tempered: it ... of cardiovascular disease and death, according to a study ... behavioural effects of long-term sleep loss have been well-documented, ... mood. But the study by researchers at the University ...
... clothes or wash dishes or even walk up to meet ... of fighting diabetes and heart disease . ,A ... spent doing low-intensity activities as simple as standing while ... their blood sugar levels. ,Population health researcher Genevieve ...
Cached Medicine News:Health News:Selection of Best X Chromosome in Women 2Health News:HIV Awareness Increases as Condoms are Distributed in Gujarat Theatres Screening Porn Films 2Health News:China Admits Fake Blood Protein Used in Drips 2Health News:Armed Forces Enroll Wives in Fighting HIV/AIDS 2Health News:Insufficient Sleep Increases Risk of Cardiovascular Disease: Study 2Health News:Iron Clothes to Lower Blood Sugar Levels 2
(Date:7/28/2014)... , July 28, 2014  Air Products (NYSE: ... of medical oxygen is vital to any healthcare facility. ... that not only improve the efficiency of its oxygen ... will highlight these systems—including systems for emergency oxygen ... loss—from August 4-5 at the 51 st ...
(Date:7/28/2014)... , July 28, 2014 Southern Research ... , Ph.D., President and CEO of Southern Research ... Release Society (CRS) for the 2014-2015 term.  The ... on July 12 in Chicago ... The Controlled Release Society is ...
(Date:7/28/2014)... , July 28, 2014  A prospective ... Sweden has validated the performance ... platforms and has associated volumetrically assessed breast density ... Cancer Epidemiology, Biomarkers & Prevention (DOI: 10.1158/1055-9965.EPI-13-1219), ... a tool for widespread breast cancer risk assessment," ...
Breaking Medicine Technology:Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 2Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 3Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 2Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 3Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 2Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 3Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 4
... 2011 Caliper Life Sciences, Inc. (NASDAQ: ... company,s first quarter financial results at 9:00 am Eastern ... Hrusovsky, President and Chief Executive Officer and Peter McAree, ... discuss operational and financial results and the company,s outlook ...
... CARY, N.C., April 20, 2011 Cetero ... (CRO), will present a scientific seminar series for pharmaceutical ... and Conducting an Accelerated Proof-of-Concept Program ." The seminars, ... fall of 2010, will share best practices on how ...
Cached Medicine Technology:Caliper Life Sciences' First Quarter Results Conference Call Notice 2Cetero Research Seminars Provide Insights on Designing Accelerated Proof-of-Concept Studies 2Cetero Research Seminars Provide Insights on Designing Accelerated Proof-of-Concept Studies 3
This 10 L tip was designed for the Pipetman P-2 and P-10. Its MicroPoint design and 2 ul reference mark make it ideal for low volume pipetting....
... to optimize the accuracy and precision of ... is widely recognized by customers throughout the ... over the years and now covers a ... including filter tips, certified pure tips, stepper ...
Designed to fit the Brinkmann Tranferpette and Treff Multi-Channel 300 L Pipettors, this tip provides extra space for repeat pipetting....
The larger volume alternative to the ART Gel 20P, this gel loading tip can load up to 100 L....
Medicine Products: