Navigation Links
Researchers discover new enzyme in cancer growth
Date:12/3/2008

OKLAHOMA CITY While studying the mechanics of blood clots, researchers at the University of Oklahoma Health Sciences Center discovered a new enzyme that not only affects the blood, but seems to play a primary role in how cancer tumors expand and spread throughout the body. The research appeared in recent issues of the journal Blood and the Journal of Thrombosis and Haemostasis.

A research group at OU led by Patrick McKee first discovered the enzyme called sFAP in plasma. After studying the biochemical makeup of the protein and identifying the gene that controlled its function, they began to search gene sequencing databases worldwide to find what it was. They didn't find the enzyme listed for blood, but got a match with a virtually identical protein known to cause cell growth in tissue, including in cancer. With McKee's discovery that the protein also exists in blood, scientists have a new avenue to study the spread of cancer.

"One thing all cancer cells need as they grow is something that acts as scaffolding. They have to attach to the scaffolding to divide and migrate. This enzyme excavates space around a malignancy and helps create the scaffolding," said McKee, M.D., principle investigator on the project.

The main function of the original FAP protein that was known to exist in tissue is to accelerate tissue growth and expand cells during fetal development, the healing of severe wounds and during growth of selected cancers such as breast, lung, pancreatic and colon.

Other than in these situations, the original form of FAP is not normally expressed in tissues at all. When it does appear, the protein helps activated fibroblasts, which growing cancer cells are able to recruit and stimulate to multiply within the malignancy itself. This creates space and the framework on which cancer cells attach, divide and eventually spread.

If FAP could be inhibited, then cancer growth could be slowed or halted
'/>"/>

Contact: Diane Clay
diane-clay@ouhsc.edu
405-271-2323
University of Oklahoma
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Researchers identify cell group key to Lyme disease arthritis
2. Interferon needed for cells to remember how to defeat a virus, UT Southwestern researchers report
3. Children Tell Researchers: Well Get Fit if Its Fun
4. Researchers identify how binge drinking may drive heart disease
5. UCSD researchers identify potential new drug target for chronic leukemia
6. USC researchers identify novel approach for suppressing prostate cancer development
7. Researchers identify new leprosy bacterium
8. UT Southwestern researchers develop new strategy for broad spectrum anti-viral drugs
9. Researchers discover strategy for predicting the immunity of vaccines
10. Ability to quit smoking may depend on ADHD symptoms, Columbia researchers find
11. Researchers ID Suite of Genes in Aging Process
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers discover new enzyme in cancer growth
(Date:12/20/2014)... 2014 The Doctor’s Office Urgent Care of ... part of a decade. They’ve treated over 40,000 patients ... healthcare alternative to the Paramus area. , ... additions to their staff of top-notch board certified physicians: Christine ... These new doctors will work tirelessly to carry ...
(Date:12/20/2014)... 20, 2014 Recently, AngelWeddingDress.com has introduced ... ”) for the coming Christmas. In the promotion, all ... off. , “We have something special for the women ... holiday season. Moreover, our new collections of 2015 dresses ... offered now at greatly discounted prices. Visit our website ...
(Date:12/20/2014)... 2014 Today, Balfleet.com, one of the ... Sale, offering 50%-70% off on its Mother of ... The mother of the bride dresses from Balfleet.com feature ... 24/7 accessible and takes pride in providing high quality ... are offering great discounts on our mother of the ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 Energy ... Bedsheets are now available. Celliant, the world’s leading ... sheets and pillowcases. , There are a number ... additional circulation, increased oxygenation and balanced body temperature; ... healing and pain relief; enhanced athletic performance; and ...
(Date:12/19/2014)... These vanadium reserves are mostly found in ... tons of vanadium were produced globally in 2013, up ... at 6.7% AAGR during the period from 2001 to ... the largest consumer, accounted for more than 90% of ... and the chemical industry. , View Full Report at ...
Breaking Medicine News(10 mins):Health News:The Doctor's Office Urgent Care Adds 3 New Physicians to Their Growing Medical Team 2Health News:AngelWeddingDress Has Introduced Its Special Offer For The Coming Christmas 2Health News:Balfleet.com is Offering 50%-70% Off of its Mother of the Bride Dresses 2Health News:Energy Textiles Launches Celliant Revitalizing Bedsheets 2Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 2Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 3
... the immune cells and incorporating it into the vaccine ... ,Researchers from the University of Pittsburgh have ... patients with HIV, subject their immune system cells through ... in their fight against the disease. Announcing their findings ...
... 12 after no new cases emerged since the February/March outbreak ... its status as an avian influenza free country and a ... Organisation of Animal Health yesterday," said a statement issued by ... bird flu outbreak among poultry on February 18 at Navapur ...
... packaging that contains latex, which will certainly prevent the allergic ... UK showed that nearly a third of food packaging was ... biscuit, the quantity of latex was so high to have ... from the UK Latex Allergy Support Group (LASG) Advisory Panel ...
... good managers and appropriate IT may be a far ... doctors and nurses than recruiting more staff,// according to ... who are against reforming the NHS blame problems on ... judgement, and the “greedy” private sector. But there is ...
... was diagnosed with tuberculosis, precautionary letters have been sent ... of them contracting the// disease. The condition of ... be satisfactory. ,The patient was diagnosed ... to the infectious diseases unit at Aberdeen Royal Infirmary ...
... the breast lesion by taking x-ray of the lesion ... radiologists. "Contrast-enhanced// MRI of the breast is becoming increasingly ... with other techniques," said Basak Erguvan-Dogan, MD, radiologist in ... Cancer Center in Houston. "However, it is hard to ...
Cached Medicine News:Health News:Activated T-Cells Could Help In The Battle Against HIV 2Health News:Activated T-Cells Could Help In The Battle Against HIV 3Health News:Food Packaging Containing Latex May Trigger an Allergic Reaction 2Health News:More and Better Management Is Key to Fixing the NHS 2Health News:MRI-guided Breast Biopsy Pronounced a Success 2
(Date:12/17/2014)... , Dec. 17, 2014 Royal Philips ... (NASDAQ: VOLC ), a global leader in catheter-based ... they have entered into a definitive merger agreement. Pursuant to ... all of the issued and outstanding shares of Volcano for ... of USD 1 billion (approx. EUR 800 million), to be ...
(Date:12/17/2014)... 17, 2014  Northstar Global Business Services, Inc. ... (DTC) has made their final decision and has ... Company,s stock effective December 15, 2014, and has ... depository and book entry transfer services. All deposit restrictions ... once again fully "DTC Eligible", and has resumed ...
(Date:12/17/2014)... , Dec. 17, 2014  ImmunoCellular Therapeutics, ... US Patent and Trademark Office (USPTO) has issued ... a dendritic cell-based immunotherapeutic vaccine targeting six tumor ... claims of US Patent No. 8,871,211, which issued ... cancer by administering a dendritic cell composition comprising ...
Breaking Medicine Technology:Philips to acquire Volcano to expand global leadership position in image-guided therapy market 2Philips to acquire Volcano to expand global leadership position in image-guided therapy market 3Philips to acquire Volcano to expand global leadership position in image-guided therapy market 4Philips to acquire Volcano to expand global leadership position in image-guided therapy market 5Philips to acquire Volcano to expand global leadership position in image-guided therapy market 6Philips to acquire Volcano to expand global leadership position in image-guided therapy market 7Philips to acquire Volcano to expand global leadership position in image-guided therapy market 8Northstar announces that the DTC chill on MDIN has been officially lifted 2Northstar announces that the DTC chill on MDIN has been officially lifted 3ImmunoCellular Therapeutics Announces Issuance of Key Patent For ICT-107 Cancer Vaccine 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: