Navigation Links
Researchers discover metabolite linked to aggressive prostate cancer
Date:2/11/2009

cks Endowed Professor of Pathology at the U-M Medical School.

The researchers looked at 1,126 metabolites across 262 samples of tissue, blood or urine associated with benign prostate tissue, early stage prostate cancer and advanced, or metastatic, prostate cancer. They mapped the alterations in metabolites and identified about 10 that were present more often in prostate cancer than in the benign cells and were present most often in the advanced cancer samples.

"When we're looking at metabolites, we're looking several steps beyond genes and proteins. It allows us to look very deeply at some of the functions of the cells and the biochemistry that occurs during cancer development," says Chinnaiyan, a Howard Hughes Medical Institute investigator.

One metabolite in particular, sarcosine, appeared to be one of the strongest indicators of advanced disease. Levels of sarcosine, an amino acid, were elevated in 79 percent of the metastatic prostate cancer samples and in 42 percent of the early stage cancer samples. Sarcosine was not found at all in the cancer-free samples.

In the study, sarcosine was a better indicator of advancing disease than the traditional prostate specific antigen, or PSA, test that is currently used to monitor or screen for prostate cancer. Sarcosine was detected in the urine, which has researchers hopeful that a simple urine test could be used.

In addition, the researchers found that sarcosine is involved in the same pathways that are linked to cancer invasiveness. This suggests sarcosine as a potential target for future drug development.

"This research gets at characterizing the chemical complexity of a sample of blood. In the future, this science will drive how doctors make treatment recommendations for their patients," says study author Christopher Beecher, Ph.D., professor of pathology at the U-M Medical School.

Results are preliminary at this point and will need years of further test
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Researchers Identify Novel Mechanism That Make Cancer Tumors Grow
2. Pathologically elevated blood fat levels in obesity: Researchers discover molecular causes
3. Georgia State researchers shed light on fat burning
4. A better mesh: Researchers tighten bodys protective coating
5. Researchers design re-engineered hospital discharge program to reduce rehospitalization
6. UVA researchers uncover genes role in severity of drinking
7. Johns Hopkins researchers discover new schizophrenia gene
8. Researchers find culture of academic institution may influence health care delivery
9. ISU researchers develop technique for quick detection of Salmonella
10. Study of Iraq veterans traumatic brain injuries to be conducted by UB researchers
11. UT Southwestern researchers identify protein that may explain healthy obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... , ... The Kentucky State Department of Workforce Investment Commissioner Beth Kuhn recently ... for, they are unable to pass the initial drug test and therefore unable to ... order to be able to hire long-term, skilled talent. (1) Will Wesch, Director of ...
(Date:8/28/2015)... ... 28, 2015 , ... For Dallas, the time is nearing for the annual ... Tenet Health. , The American Heart Association hosts their well-known Heart Walk to raise ... together, a difference can be made. Walkers can participate in the cause and someone ...
(Date:8/28/2015)... ... August 28, 2015 , ... The 6th Annual Survivor in the City, ... added yet another accolade to its cadre of widespread support—an official letter of support ... help of the medical community and the University of Illinois at Chicago’s Department of ...
(Date:8/28/2015)... ... August 28, 2015 , ... Saint Petersburg, FL —Pocket Protein™, ... fat, carbs, sugar, gluten, lactose or caffeine in a convenient 2 oz. pouch ... CPG Editor’s Choice Awards. , Five consumer packaged goods (CPG) products were selected ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... ... businesses nationwide. Addictions specialist, Dr. James Strawbridge, gives a new approach on solutions ... it should begin with the employer and employees getting together for meaningful group ...
Breaking Medicine News(10 mins):Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 2Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 3Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 4Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 3Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 2Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 3
... its toll on Hong Kong teachers, with one in three ... ,Shouting at students in the class is affecting the ... said dry throats and husky and harsh voices were among ... developed voices like men., ,Researchers claim the problem ...
... relatives of people with autism may display autistic brain differences ... not suffer from the disorder themselves. //, ... at the annual meeting of the Society of Neuroscience, in ... Colorado in Denver, USA. , ,Autism, which ...
... poultry products from Taiwan, Hong Kong, and four other ... 17.//,The step has come as a precaution against the ... ,Last month, Pakistan put a similar ban on 13 ... Cambodia, Laos, Russia, Kazakhstan, Mongolia, Turkey, Greece and Romania. ...
... nerve damage in mice by using tissues differentiated from ... with an injured nervous system with their own hair ... research suggest hair follicle stem cells can promote nervous ... offering an opportunity for the clinical treatment of peripheral ...
... suggests that people could be putting their health at ... chiropodists, dieticians and other health professionals.// ,The survey ... by the Health Professions Council (HPC), found that about ... a health professional were oblivious to whether they were ...
... food tend to gain more bone mass than those who ... ,The team conducted the study to learn how to ... of puberty in which 60 percent of the adult bone ... ,The study, published in the November issue of the American ...
Cached Medicine News:Health News:Stem Cells From Hair Follicle To Repair Nerve Damage 2Health News:Credentials Of Specialists Need To Be Checked 2Health News:Calcium From Food Better Than From Supplements 2
(Date:8/28/2015)... Research and Markets ( ... "Investigation Report on China,s Tobramycin Market, 2010-2019" report ... antibiotic whose eye drop and ointment are the most ... or inflammation caused by eye infection. Currently, dozens of ... to produce tobramycin, among which the Top 5 are ...
(Date:8/28/2015)... 28, 2015 Research ... addition of the "Investigation Report on China,s ... Developed by Pharmacia & Upjohn in ... which effectively reduces intraocular pressure. As the first ... the trade name of Xalatan) entered ...
(Date:8/28/2015)... Company plc ("Perrigo") (NYSE: PRGO ; TASE) today ... OTC brands from GSK in an all cash transaction ... demonstration of Perrigo,s unique ability to maximize brand value ... countries.  Perrigo Chairman, President and CEO ... to complete this transaction, which clearly demonstrates our ability ...
Breaking Medicine Technology:Investigation Report on China's Tobramycin Market, 2015-2019 2China Latanoprost Market Investigation Report 2015-2019 2Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 2Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 3Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 4
... 2012  Particle Sciences, a leading drug delivery CRO, ... DOSE™ program.  The DOSE™ program uses a combination ... efficiently arrive at the optimal drug product for ... Sciences implemented software solutions for calculating and predicting ...
... Jan. 3, 2012  Accera, Inc., a privately-held, commercial-stage, healthcare ... therapeutics to treat central nervous system disorders, announced today ... of Chief Executive Officer and as a member of ... Ph.D., has also been appointed as a member of ...
Cached Medicine Technology:Particle Sciences Expands Its DOSE™ Program With Additional Proprietary Modeling Capabilities 2Accera, Inc. Elects Industry Veteran Holger Kunze as CEO and as a Member of the Company's Board of Directors 2Accera, Inc. Elects Industry Veteran Holger Kunze as CEO and as a Member of the Company's Board of Directors 3
Disposable Microscissors: Horizontal, Curved...
Disposable Microscissors: Horizontal, Straight...
Disposable Microscissors: Vertical, 90...
Low profile, sharp-tipped scissors with a vertical cutting action. Excellent for peeling and cutting fine epiretinal membranes....
Medicine Products: